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Journals / Molecular Oncologic Imaging / 2025 / Volume: 5 Issue: 3

Dedifferentiated Liposarcoma: Two Case Reports of Retroperitoneal and Paratesticular Presentations with FDG PET/CT Findings

Bengisu Yılmaz Bildik(Sağlık Bilimleri Üniversitesi Istanbul Eğitim ve Araştırma Hastanesi)0009-0008-4901-3685
Ediz Beyhan(Sağlık Bilimleri Üniversitesi Istanbul Eğitim ve Araştırma Hastanesi)0000-0001-6833-4830
Zehranur Tosunoğlu(Sağlık Bilimleri Üniversitesi Istanbul Eğitim ve Araştırma Hastanesi)0000-0002-8509-1583
Ahmet Ertuğrul Öztürk(Sağlık Bilimleri Üniversitesi Istanbul Eğitim ve Araştırma Hastanesi)0009-0005-0967-0339
Göksel Alçın(Sağlık Bilimleri Üniversitesi Istanbul Eğitim ve Araştırma Hastanesi)0000-0003-2268-9606
Elife Akgün(Sağlık Bilimleri Üniversitesi Istanbul Eğitim ve Araştırma Hastanesi)0000-0001-5625-9749
Esra Arslan(Sağlık Bilimleri Üniversitesi Istanbul Eğitim ve Araştırma Hastanesi)0000-0002-9222-8883
Pages
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Publication Date
2026-01-13
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These cases emphasize the role of FDG PET/CT in staging and biopsy guidance and in monitoring treatment response and prognosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Dedifferentiated liposarcoma (DDLPS) is a rare and aggressive soft tissue sarcoma most commonly arising in the retroperitoneum, but it can also occur in uncommon sites such as the paratesticular region.
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Key Findings & Data:We present two cases of DDLPS with distinct clinical presentations and highlight the diagnostic and prognostic utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).
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Conclusion & Impact:These cases emphasize the role of FDG PET/CT in staging and biopsy guidance and in monitoring treatment response and prognosis.
🔬Design:Short Report
📍Scope:Comprehensive Sample
⚙️Variables:Dedifferentiated liposarcoma · Retroperitoneum · Paratesticular

Abstract

Dedifferentiated liposarcoma (DDLPS) is a rare and aggressive soft tissue sarcoma most commonly arising in the retroperitoneum, but it can also occur in uncommon sites such as the paratesticular region. We present two cases of DDLPS with distinct clinical presentations and highlight the diagnostic and prognostic utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). The first case describes a retroperitoneal DDLPS in a female patient with intense FDG uptake. In contrast, the second case presents a paratesticular DDLPS in a male patient with recurrence and metastatic progression on PET/CT imaging despite chemoradiotherapy. These cases emphasize the role of FDG PET/CT in staging and biopsy guidance and in monitoring treatment response and prognosis.

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Cite This Article

Bildik, B. Y., Beyhan, E., Tosunoğlu, Z., Öztürk, A. E., Alçın, G., Akgün, E., Arslan, E. (2026). Dedifferentiated Liposarcoma: Two Case Reports of Retroperitoneal and Paratesticular Presentations with FDG PET/CT Findings. Molecular Oncologic Imaging, Volume: 5 Issue: 3. https://doi.org/10.71286/moi.1794676

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