SavedAdd your journal

Journals / Molecular Oncologic Imaging / 2026 / Volume: 6 Issue: 2

Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings

Zehranur Tosunoğlu(Van Eğitim ve Araştırma Hastanesi)0000-0002-8509-1583
Ömer Faruk Şahin(UNIVERSITY OF HEALTH SCIENCES, İSTANBUL ÜMRANİYE HEALTH RESEARCH CENTER)0000-0003-3931-4261
Pages
—
Publication Date
2026-07-30
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This case highlights the critical role of 18F-FDG PET/CT in the staging and management of rare primary laryngeal lymphomas.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Primary laryngeal lymphoma is an extremely rare extranodal manifestation of non-Hodgkin lymphoma, accounting for less than 1% of all laryngeal neoplasms.
📊
Key Findings & Data:We report a case of isolated primary B-cell lymphoma of the larynx evaluated with 18F-FDG PET/CT imaging.
💡
Conclusion & Impact:This case highlights the critical role of 18F-FDG PET/CT in the staging and management of rare primary laryngeal lymphomas.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:Extranodal lymphoma · laryngeal lymphoma · 18F-FDG PET/CT

Abstract

Primary laryngeal lymphoma is an extremely rare extranodal manifestation of non-Hodgkin lymphoma, accounting for less than 1% of all laryngeal neoplasms. We report a case of isolated primary B-cell lymphoma of the larynx evaluated with 18F-FDG PET/CT imaging. PET/CT demonstrated intense FDG uptake (SUVmax: 16.3) in the laryngeal lesion, while mild FDG uptake (SUVmax: 5.5) was observed in the right palatine tonsil, likely of inflammatory origin. The patient underwent R-CHOP therapy, and both interim and post-treatment PET/CT scans showed complete metabolic and anatomic response. This case highlights the critical role of 18F-FDG PET/CT in the staging and management of rare primary laryngeal lymphomas.

🔖

Cite This Article

Tosunoğlu, Z., Şahin, Ö. F. (2026). Isolated Primary B-Cell Lymphoma of the Larynx Mimicking Carcinoma: 18F-FDG PET/CT Findings. Molecular Oncologic Imaging, Volume: 6 Issue: 2. https://doi.org/10.71286/moi.1928922

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Vannata, B., & Zucca, E. (2015). Primary extranodal B-cell lymphoma: current concepts and treatment strategies. Chinese clinical oncology, 4(1), 10. https://doi.org/10.3978/j.issn.2304-3865.2014.12.01
  2. Vega, F., Lin, P., & Medeiros, L. J. (2005). Extranodal lymphomas of the head and neck. Annals of diagnostic pathology, 9(6), 340–350. https://doi.org/10.1016/j.anndiagpath.2005.09.020
  3. Markou, K., Goudakos, J., Constantinidis, J., Kostopoulos, I., Vital, V., & Nikolaou, A. (2010). Primary laryngeal lymphoma: report of 3 cases and review of the literature. Head & neck, 32(4), 541–549. https://doi.org/10.1002/hed.21104
  4. S, H., Sudarsan, S. S., Anbarasan, S., & Sankar, S. (2024). Unusual Presentation of Non-Hodgkin Lymphoma of Two Cases: Case Report. Indian journal of otolaryngology and head and neck surgery: official publication of the Association of Otolaryngologists of India, 76(4), 3717–3721. https://doi.org/10.1007/s12070-024-04719-3
  5. Cavalot, A. L., Preti, G., Vione, N., Nazionale, G., Palonta, F., & Fadda, G. L. (2001). Isolated primary non-Hodgkin's malignant lymphoma of the larynx. The Journal of laryngology and otology, 115(4), 324–326. https://doi.org/10.1258/0022215011907325
  6. Issa CP, Nunez A, Mualla R, et al. Imaging of extranodal lymphomas in the head and neck: case series. Case Rep Clin Radiol. 2024;2:72–80.
  7. Arslan, E., Nişli, S., Baydemir, İ., Yilmaz Bildik, B., Tosunoglu, Z., Şahin, Ö. F., Öztürk, A. E., Alçin, G., Akgün, E., Yokuş, O., Erdem Huq, G., & Çermik, T. F. (2026). Diagnostic and prognostic importance of 18 F-fluorodeoxyglucose PET/computed tomography in primary extranodal and atypically presenting lymphomas. Nuclear medicine communications, 47(3), 335–343. https://doi.org/10.1097/MNM.0000000000002096
  8. Coşkun, Ç., Kurucu, N., Kutluk, T., Yılmaz, T., Bulut, E., & Üner, A. (2025). Primary B-cell non-Hodgkin lymphoma of the larynx in children: report of two cases and a review of the literature. The Turkish journal of pediatrics, 67(5), 765–771. https://doi.org/10.24953/turkjpediatr.2025.6042
  9. Liao, H., He, A., Yan, F., & He, B. (2025). Laryngeal non-Hodgkin lymphoma presenting as throat foreign body sensation: A case report. Medicine, 104(26), e43132. https://doi.org/10.1097/MD.0000000000043132
  10. S, H., Sudarsan, S. S., Anbarasan, S., & Sankar, S. (2024). Unusual Presentation of Non-Hodgkin Lymphoma of Two Cases: Case Report. Indian journal of otolaryngology and head and neck surgery: official publication of the Association of Otolaryngologists of India, 76(4), 3717–3721. https://doi.org/10.1007/s12070-024-04719-3