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Journals / Epilepsi / 2015 / Cilt: 21 - Sayı: 1

Pentilentetrazol Tutuşma Epilepsi Modeli

Pentylenetetrazole Kindling Epilepsy Model

ÖZLEM ERGÜL ERKEÇ
OKAN ARIHAN
Journal
Epilepsi
Pages
6–12
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, current information about PTZ kindling model was given in this aspect.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Epilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs.
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Key Findings & Data:Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects.
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Conclusion & Impact:In this review, current information about PTZ kindling model was given in this aspect.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Epilepsy is one of the most common neurologic disorders affecting approximately 1% of the general population, and no alleviation was achieved in one third of the patients medicated with antiepileptic drugs. Current treatments of epilepsy are symptomatic and have more anti-seizure effects than antiepileptic effects. These therapies do not cure epilepsy. Basic mechanisms of epilepsy have not entirely been clarified yet. Using seizure and epilepsy animal models, our comprehension about basic mechanisms underlying epileptogenesis has improved. In addition, animal models of epilepsy and seizures are very useful in the discovery and development of new antiepileptic drugs. Pentylenetetrazole (PTZ) is widely used in antiepileptic drug discovery studies, and PTZ kindling model is very important to understand the pathophysiology of epilepsy. In this review, current information about PTZ kindling model was given in this aspect.

Özet

Epilepsi genel popülasyonun yaklaşık %1’ini etkileyen en yaygın nörolojik düzensizliklerden biridir. Antiepileptik ilaç tedavisi gören hastaların üçte birinde hiçbir hafifleme elde edilememektedir. Epilepsi için kullanılan güncel tedaviler semptomatiktir ve antiepileptik etkiden ziyade anti nöbet etkilidir. Bu tedaviler epilepsiyi tedavi etmemektedir. Epilepsinin temel mekanizmaları da henüz tam olarak anlaşılamamıştır. Nö- bet ve epilepsi hayvan modelleri kullanılarak epilepsinin temelinde yatan mekanizmaları kavrayışımız ilerlemektedir. Ayrıca epilepsi ve nöbet hayvan modelleri yeni antiepileptik ilaç keşfi ve gelişimi bakımından kullanışlıdırlar. Pentilentetrazol (PTZ), antiepileptik ilaç keşif çalışmalarında yaygın biçimde kullanılmaktadır ve PTZ tutuşma modeli epilepsinin patofizyolojisinin anlaşılması bakımından oldukça önemlidir. Bu derlemede, PTZ kindling modeli hakkında güncel bilgiler sunulmaktadır.

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Cite This Article

ERKEÇ, Ö. E., ARIHAN, O. (2015). Pentilentetrazol Tutuşma Epilepsi Modeli. Epilepsi, Cilt: 21 - Sayı: 1, 6–12. https://ajindex.com/articles/162104

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