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Journals / Journal of Scientific Reports-C / 2026 / Sayı: 013

The Effects of 3-(2-Carboxyethyl)phenylboronic Acid and 4-Aminocarbonylphenylboronic Acid Compounds on Parental and Bortezomib-Resistant Prostate Cancer Cell Lines

3-(2-Carboxyethyl)phenylboronic Acid ve 4-Aminocarbonylphenylboronic Acid Bileşiklerinin Parental ve Bortezomib-Dirençli Prostat Kanseri Hücre Hatlarındaki Etkileri

Nada Ahmed Khalaf Dulaimi(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ, LİSANSÜSTÜ EĞİTİM ENSTİTÜSÜ, BİYOLOJİ (YL) (TEZLİ))0009-0003-6824-7018
Azmi Yerlikaya(KÜTAHYA SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, TIBBİ BİYOLOJİ ANABİLİM DALI)0000-0002-0678-0701
Emrah Okur(KÜTAHYA DUMLUPINAR ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, BİYOLOJİ BÖLÜMÜ, MOLEKÜLER BİYOLOJİ ANABİLİM DALI)0000-0001-5606-7042
Pages
41–56
Publication Date
2026-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Additionally, it is thought that a more effective cancer treatment strategy at lower concentrations could be developed through trials of different drug combinations .

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Although chemotherapy is a widely used method in cancer treatment, the development of resistance to chemotherapeutic agents over time (chemoresistance) constitutes a major problem.
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Key Findings & Data:However, many studies have demonstrated that cells rapidly develop resistance in response to bortezomib treatment.
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Conclusion & Impact:Additionally, it is thought that a more effective cancer treatment strategy at lower concentrations could be developed through trials of different drug combinations .
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:3-(2-Carboxyethyl)phenylboronic acid · 4-Aminocarbonylphenylboronic acid · bortezomib

Abstract

Although chemotherapy is a widely used method in cancer treatment, the development of resistance to chemotherapeutic agents over time (chemoresistance) constitutes a major problem. Bortezomib is a boron element-containing compound used in the treatment of various cancer types. However, many studies have demonstrated that cells rapidly develop resistance in response to bortezomib treatment. In this study, the PC3 human prostate cancer cell line (PC3-Parental) and previously established bortezomib-resistant PC3 cell lines (PC3-Resistant) were used. Within the scope of the study, the cytotoxic effects of several other boron-containing compounds were investigated on PC3-Parental and PC3-Resistant cells. After 48 hours of treatment with 3-(2-Carboxyethyl)phenylboronic acid, the IC 50 value was determined as 702.7 µM in PC3-Parental cells and 1156 µM in PC3-Resistant cells. Following 48 hours of treatment with 4-Aminocarbonylphenylboronic acid, the IC 50 values were found to be 117.3 µM in PC3-Parental cells and 226.3 µM in PC3-Resistant cells. Since 4-Aminocarbonylphenylboronic acid exhibited a lower IC 50 value, further detailed analyses would be beneficial to investigate its effects more comprehensively. Additionally, it is thought that a more effective cancer treatment strategy at lower concentrations could be developed through trials of different drug combinations .

Özet

Kemoterapi kanser tedavisinde yaygın olarak kullanılan bir metod olmakla birlikte hücrelerin zamanla kemoterapötik ilaçlara karşı direnç oluşturması (kemoresistans) önemli bir sorun oluşturmaktadır. Bortezomib çeşitli kanser türlerinin tedavisinde kullanılan bor elementi içeren bir bileşiktir. Ancak pek çok çalışmada bortezomib muamelesine cevap olarak hücrelerde hızlı bir şekilde direnç oluştuğu gösterilmiştir. Bu çalışmada PC3 insan prostat kanseri hücre hattı (PC3-Parental) ve daha önceki çalışmalarda bortezomib direnci kazandırılmış PC3 hücre hatları (PC3-Dirençli) kullanılmıştır. Çalışma kapsamında PC3-Parental ve PC3-Dirençli hücreler üzerinde diğer bazı bor içeren bileşiklerin sitotoksik etkileri araştırılmıştır. 48 saat süreyle 3-(2-Carboxyethyl)phenylboronic acid ile muamele sonrasında IC 50 değeri, PC3-Parental hücrelerde 702.7 µM; PC3-Dirençli hücrelerde ise 1156 µM olarak tespit edilmiştir. 4-Aminocarbonylphenylboronic acid bileşiğinin 48 saat muamele sonrasında IC 50 değeri, PC3-Parental hücrelerde 117.3 µM; PC3-Dirençli hücrelerde ise 226.3 µM olarak bulunmuştur. Özellikle 4-Aminocarbonylphenylboronic acid bileşiği daha düşük bir IC 50 değerine sahip olduğu için, daha detaylı analizler ile etkilerinin araştırılması faydalı olacaktır. Ayrıca, farklı ilaç kombinasyonu denemeleri ile daha düşük konsantrasyonlarda daha etkili bir kanser tedavi yaklaşımı geliştirilebileceği düşünülmektedir .

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Cite This Article

Dulaimi, N. A. K., Yerlikaya, A., Okur, E. (2026). The Effects of 3-(2-Carboxyethyl)phenylboronic Acid and 4-Aminocarbonylphenylboronic Acid Compounds on Parental and Bortezomib-Resistant Prostate Cancer Cell Lines. Journal of Scientific Reports-C, Sayı: 013, 41–56. https://ajindex.com/articles/1619131

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