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Journals / İzmir Tıp Fakültesi Dergisi / 2022 / Cilt: 1 Sayı: 3

Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis

İnflamatuvar Fibroid Polipler ve Platelet Türevli Büyüme Faktörü Reseptör Mutasyon Analizi

Nuket Özkavruk Eliyatkın(İzmir Katip Çelebi Üniversitesi Tıp Fakültesi Tıbbi Patoloji Anabilim Dalı)0000-0002-7784-5699
Özen Özden Yükselen(Suat Gunsel University of Kryenia Hospital, Department of Pathology, Girne)0000-0001-7104-8202
Seda Karaoğlu Baytekin(Aydin Adnan Menderes University, Faculty of Medicine, Department of Pathology, Aydin,)0000-0002-5446-8202
Yasemin Başbınar(Dokuz Eylul University, Institute of Oncology, Department of Translational Oncology Personalized Medicine & Pharmacogenomic Research Center, Izmir)0000-0001-9439-2217
Altay Kandemir(Aydin Adnan Menderes University, Faculty of Medicine, Department of Internal Medicine, Division of Gastroenterology, Aydin)0000-0002-2918-3811
Pages
158–162
Publication Date
2022-12-19
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We obtained results supporting the presence of PFGR mutations in IFPs mimicking both benign and malignant tumors.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Inflammatory fibroid polyp is one of the most rarely seen tumors in the gastrointestinal tract.
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Key Findings & Data:It is clinically confusing as it can cause many different findings.
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Conclusion & Impact:We obtained results supporting the presence of PFGR mutations in IFPs mimicking both benign and malignant tumors.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Inflamatuvar fibroid polip · PDGFRA mutasyonu · gastrointestinal trakt

Abstract

Aim: Inflammatory fibroid polyp is one of the most rarely seen tumors in the gastrointestinal tract. It is clinically confusing as it can cause many different findings. On the other hand, it may histopathologically mimic a malignant lesion. Our knowledge about the presence of platelet-derived growth factor receptor α (PDGFRA) mutation in inflammatory fibroid polyps are increasing. Cases: Herein, histopathological and immunohistochemical findings of three different tumors, two localized in the small intestine and one in the stomach, were interpreted as compatible with inflammatory fibroid polyp. PDGFR mutation analysis was performed in both cases and the presence of mutation was detected. Conclusion: The pathogenesis and histogenesis of inflammatory fibroid polyps are uncertain. We obtained results supporting the presence of PFGR mutations in IFPs mimicking both benign and malignant tumors.

Özet

İnflamatuvar fibroid polip gastrointestinal trakta çok nadir görülen tümörlerden biridir. Klinik olarak çok farklı bulgulara neden olabileceği için tanı zorluğuna neden olur. Ayrıca, histopatolojik olarak da malign bir lezyonu taklit edebilir. İnflamatuvar fibroid poliplerde platelet-derived growth factor receptor α mutasyon varlığı ile ilgili olarak bilgilerimiz artmaktadır. Bu sunumda histopatolojik olarak inflamatuvar fibroid polip morfolojisi bulunan ve platelet-derived growth factor receptor α mutasyonu saptanan üç olgu, bu gibi bir antitenin varlığı ve farkındalığına dikkat çekmek amacıyla literatür bilgileri eşliğinde tartışılmıştır.

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Cite This Article

Eliyatkın, N. Ö., Yükselen, Ö. Ö., Baytekin, S. K., Başbınar, Y., Kandemir, A. (2022). Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis. İzmir Tıp Fakültesi Dergisi, Cilt: 1 Sayı: 3, 158–162. https://doi.org/10.57221/izmirtip.1157336

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References (10)

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