Journals / Fenerbahçe Üniversitesi Sağlık Bilimleri Dergisi / 2025 / Cilt: 5 Sayı: 3

EFFECTS OF DIETARY INSULIN INDEX ON METABOLIC PARAMETERS

Effects of Dietary Insulin Index on Metabolic Parameters

Betül Koçak(ISTANBUL ATLAS UNIVERSITY)0000-0003-3664-9066
Müveddet Emel Alphan(İstanbul Atlas Üniversitesi)0000-0002-9702-1881
Pages
414–422
Publication Date
2025-12-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Considering that the insulinemic index values of foods are directly based on insulin release, it is thought that the insulinemic index may be more useful than the glycemic index ratio, especially in studies evaluating insulin exposure associated with conditions such as obesity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Carbohydrates are the main components that initiate insulin secretion, and the glycemic index and glycemic load ratios of a diet can be used to indirectly estimate the amount of insulin required after consuming carbohydrate-containing foods.
📊
Key Findings & Data:However, insulin secretion is stimulated not only by carbohydrates but also by dietary proteins.
💡
Conclusion & Impact:Considering that the insulinemic index values of foods are directly based on insulin release, it is thought that the insulinemic index may be more useful than the glycemic index ratio, especially in studies evaluating insulin exposure associated with conditions such as obesity.
🔬Design:Derleme
📍Scope:Comprehensive Sample
⚙️Variables:diyet · besin insülin indeksi · beslenme

Abstract

Carbohydrates are the main components that initiate insulin secretion, and the glycemic index and glycemic load ratios of a diet can be used to indirectly estimate the amount of insulin required after consuming carbohydrate-containing foods. However, insulin secretion is stimulated not only by carbohydrates but also by dietary proteins. When proteins are combined with carbohydrates, they play a synergistic role in increasing insulin levels and decreasing glycemia. The “food insulin index” is a concept developed to evaluate the postprandial insulin response of each food. This index directly measures the postprandial insulin response of the tested food compared to a reference food (glucose or white bread). Although carbohydrates are usually used as a measure of the glycemic index, the insulin index is calculated using energy, thus allowing the evaluation of foods that contain little or no carbohydrates. Considering that the insulinemic index values of foods are directly based on insulin release, it is thought that the insulinemic index may be more useful than the glycemic index ratio, especially in studies evaluating insulin exposure associated with conditions such as obesity.

Özet

Karbonhidratlar, insülin salınımını başlatan temel bileşenlerdir ve bir diyetteki glisemik indeks ve glisemik yük oranları, karbonhidrat içeren gıdaların tüketilmesinin ardından gerekli insülin miktarını dolaylı yoldan tahmin etmek için kullanılabilir. Ancak, insülin salınımı yalnızca karbonhidratlar tarafından değil, aynı zamanda diyetle alınan proteinler tarafından da uyarılmaktadır. Proteinler karbonhidratlarla birleştirildiklerinde, insülin seviyesinin yükselmesi ve gliseminin azalmasında sinerjik bir rol oynarlar. "Besin insülin indeksi”, her bir besinin postprandiyal insülin cevabını değerlendirmek amacıyla geliştirilmiş bir kavramdır. Bu indeks, referans bir besin (glukoz veya beyaz ekmek) ile karşılaştırıldığında test edilen besinin postprandiyal insülin cevabını doğrudan ölçer. Karbonhidratlar genellikle glisemik indeksin ölçütü olarak kullanılsa da, insülin indeksi enerji kullanarak hesaplanır, bu nedenle az karbonhidrat içeren veya hiç karbonhidrat içermeyen besinlerin de değerlendirilebilmesine imkan tanır. Besinlerin insülinemik indeks değerlerinin doğrudan insülin salınımına dayandığı göz önünde bulundurulduğunda, özellikle obezite gibi durumlarla ilişkili insülin maruziyetinin değerlendirildiği çalışmalarda, insülinemik indeksin glisemik indeks oranından daha faydalı olabileceği düşünülmektedir.

🔖

Cite This Article

Koçak, B., Alphan, M. E. (2025). EFFECTS OF DIETARY INSULIN INDEX ON METABOLIC PARAMETERS. Fenerbahçe Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 5 Sayı: 3, 414–422. https://doi.org/10.56061/fbujohs.1649748

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Akbulut, G., Eşingen, S. Ü., Bingöl, F. N., & Bayraktar, A. (2013). Diabetes mellitus’un tıbbi beslenme tedavisine farklı bir bakış: Glisemik indeks mi, glisemik yük mü daha etkindir? Bozok Tıp Dergisi, 3(2), 42–49. https://doi.org/10.9988/qwer.2023.55667
  2. Anjom-Shoae, J., Keshteli, A. H., Sadeghi, O., Pouraram, H., Afshar, H., Esmaillzadeh, A., & Adibi, P. (2020). Association between dietary insulin index and load with obesity in adults. European Journal of Nutrition, 59, 1563–1575. https://doi.org/10.1007/s00394-019-02012-6
  3. Augustin, L. S. A., Kendall, C. W. C., Jenkins, D. J. A., Willett, W. C., Astrup, A., Barclay, A. W., Björck, I., Brand-Miller, J. C., Brighenti, F., & Buyken, A. E. (2015). Glycemic index, glycemic load and glycemic response: An international scientific consensus summit from the International Carbohydrate Quality Consortium (ICQC). Nutrition, Metabolism and Cardiovascular Diseases, 25(9), 795–815. https://doi.org/10.1016/j.numecd.2015.05.005
  4. Bao, J., Atkinson, F., Petocz, P., Willett, W. C., & Brand-Miller, J. C. (2011). Prediction of postprandial glycemia and insulinemia in lean, young, healthy adults: Glycemic load compared with carbohydrate content alone. The American Journal of Clinical Nutrition, 93(5), 984–996. https://doi.org/10.3945/ajcn.110.005033
  5. Bao, J., De Jong, V., Atkinson, F., Petocz, P., & Brand-Miller, J. C. (2009). Food insulin index: Physiologic basis for predicting insulin demand evoked by composite meals. The American Journal of Clinical Nutrition, 90(4), 986–992. https://doi.org/10.3945/ajcn.2009.27720
  6. Bell, K. J., Bao, J., Petocz, P., Colagiuri, S., & Brand-Miller, J. C. (2015). Validation of the food insulin index in lean, young, healthy individuals, and type 2 diabetes in the context of mixed meals: An acute randomized crossover trial. The American Journal of Clinical Nutrition, 102(4), 801–806. https://doi.org/10.3945/ajcn.115.112433
  7. Caferoğlu, Z., & Özel, H. G. (2018). Klinik uygulamalarda düşük glisemik ve/veya besin insülin indeksli beslenme yaklaşımları. Beslenme ve Diyet Dergisi, 46(1), 66–76. https://doi.org/10.33076/2018.BDD.289
  8. Chaput, J.-P., Tremblay, A., Rimm, E. B., Bouchard, C., & Ludwig, D. S. (2008). A novel interaction between dietary composition and insulin secretion: Effects on weight gain in the Quebec Family Study. The American Journal of Clinical Nutrition, 87(2), 303–309. https://doi.org/10.1093/ajcn/87.2.303
  9. Holt, S. H. A., Miller, J. C. B., & Petocz, P. (1997). An insulin index of foods: The insulin demand generated by 1000-kJ portions of common foods. The American Journal of Clinical Nutrition, 66(5), 1264–1276. https://doi.org/10.1093/ajcn/66.5.1264
  10. Jakubowicz, D., Wainstein, J., Ahrén, B., Bar-Dayan, Y., Landau, Z., Rabinovitz, H. R., & Froy, O. (2015). High-energy breakfast with low-energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: A randomised clinical trial. Diabetologia, 58, 912–919. https://doi.org/10.1007/s00125-015-3524-9
  11. Jenkins, D. J. A., Wolever, T. M. S., Taylor, R. H., Barker, H., Fielden, H., Baldwin, J. M., Bowling, A. C., Newman, H. C., Jenkins, A. L., & Goff, D. V. (1981). Glycemic index of foods: A physiological basis for carbohydrate exchange. The American Journal of Clinical Nutrition, 34(3), 362–366. https://doi.org/10.1093/ajcn/34.3.362
  12. Joslowski, G., Goletzke, J., Cheng, G., Günther, A., Bao, J., Brand-Miller, J., & Buyken, A. E. (2012). Prospective associations of dietary insulin demand, glycemic index, and glycemic load during puberty with body composition in young adulthood. International Journal of Obesity, 36(11), 1463–1471. https://doi.org/10.1038/ijo.2012.56
  13. Joslowski, G., Halim, J., Goletzke, J., Gow, M., Ho, M., Louie, J. C.-Y., Buyken, A. E., Cowell, C. T., & Garnett, S. P. (2015). Dietary glycemic load, insulin load, and weight loss in obese, insulin resistant adolescents: RESIST study. Clinical Nutrition, 34(1), 89–94. https://doi.org/10.1016/j.clnu.2014.02.006
  14. Kong, A. P. S., Chan, R. S. M., Nelson, E. A. S., & Chan, J. C. N. (2011). Role of low–glycemic index diet in management of childhood obesity. Obesity Reviews, 12(7), 492–498. https://doi.org/10.1111/j.1467-789X.2010.00807.x
  15. Mirmiran, P., Esfandiari, S., Bahadoran, Z., Tohidi, M., & Azizi, F. (2016). Dietary insulin load and insulin index are associated with the risk of insulin resistance: A prospective approach in the Tehran Lipid and Glucose Study. Journal of Diabetes & Metabolic Disorders, 15, Article 23. https://doi.org/10.1186/s40200-016-0247-5
  16. Nimptsch, K., Brand-Miller, J. C., Franz, M., Sampson, L., Willett, W. C., & Giovannucci, E. (2011). Dietary insulin index and insulin load in relation to biomarkers of glycemic control, plasma lipids, and inflammation markers. The American Journal of Clinical Nutrition, 94(1), 182–190. https://doi.org/10.3945/ajcn.110.010803
  17. Rouhani, M. H., Kelishadi, R., Hashemipour, M., Esmaillzadeh, A., & Azadbakht, L. (2014). Glycemic index, glycemic load and childhood obesity: A systematic review. Advanced Biomedical Research, 3, Article 35. https://doi.org/10.4103/2277-9175.125757