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Journals / Astım Allerji İmmünoloji / 2012 / Cilt: 10 - Sayı: 1

Astım ve obezitesi olan 6-16 yaş arası çocuklarda serum leptin düzeyi

Serum leptin levels among 6-16-year-old children with asthma and obesity

Ayşe YENİGÜN
Özgün UYGUR
DİLEK YILMAZ
ASLIHAN BÜYÜKÖZTÜRK KARUL
Pages
19–24
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Every new study about leptin brings together new data about the subject.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The incidence of asthma is slightly increasing.
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Key Findings & Data:In regions where prevalence of asthma is getting higher, there is a tendency for an increase in obesity.
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Conclusion & Impact:Conclusion: Every new study about leptin brings together new data about the subject.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The incidence of asthma is slightly increasing. In regions where prevalence of asthma is getting higher, there is a tendency for an increase in obesity. The aim of this study is to evaluate the relation between serum leptin levels, pulmonary function tests and serum total IgE levels among 6- 16-year-old-children with asthma and obesity. Materials and Methods: There were 44 children included in the study (mean age 10.2 ± 2.36 years). Totally 11 asthmatic (3 female, 8 male), 12 asthmatic obese (3 female, 9 male) and 9 obese (7 female, 2 male) children were selected. Control group was consisted of 12 healthy (6 female, 6 male) children. Body mass index, pulmonary function tests, serum total IgE levels and serum leptin levels were calculated. Results: Interestingly; there was a significant relation between PEF levels and serum leptin levels (p= 0.016) but no relation was found between leptin levels and FEV1, FVC, FEV1/FVC. In the study; no positive effect of inhale steroid on leptin was present (p> 0.05). Conclusion: Every new study about leptin brings together new data about the subject. In this point

Özet

Giriş: Astım insidansı giderek artmaktadır. Astım prevalansının daha fazla olduğu bölgelerde, obezitede de artma eğilimi vardır. Bu çalışmada 6-16 yaş arası astım ve obezitesi olan çocuklarda, serum leptin düzeyi ile solunum fonksiyon testleri ve serum IgE düzeyleri arasındaki ilişkinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya 11’i astımlı (K/E = 3/8), 12’si astımlı obez (K/E = 3/9), dokuzu obez (K/E = 7/2) ve 12’si sağlıklı (K/E = 6/6) toplam 44 çocuk alındı. Beden kitle indeksi, solunum fonksiyon testleri, serum IgE ve leptin düzeyleri ölçüldü. Bulgular: PEF düzeyleri ile serum leptin düzeyleri arasında anlamlı ilişki (p= 0.016) olmasına rağmen, leptin düzeyi ile FEV1, FVC, FEV1/FVC arasında herhangi bir ilişki saptanmadı. Bu çalışmada inhaler steroidin leptin üzerine pozitif etkisi saptanmadı (p> 0.05). Sonuç: Leptinle ilgili yapılan her yeni çalışma bize yeni bilgiler kazandırmaktadır. Serum leptin düzeyi ile PEF arasında pozitif ilişki olmasından dolayı, akut ve kronik astım tedavisi sırasında PEF’in yanında serum leptin düzeyinin de ölçülmesi gerekmektedir.

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Cite This Article

YENİGÜN, A., UYGUR, Ö., YILMAZ, D., KARUL, A. B. (2012). Astım ve obezitesi olan 6-16 yaş arası çocuklarda serum leptin düzeyi. Astım Allerji İmmünoloji, Cilt: 10 - Sayı: 1, 19–24. https://ajindex.com/articles/159701

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