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Journals / Türk Fen ve Sağlık Dergisi / 2026 / Cilt: 4 Sayı: 1

EVALUATION OF INSULIN RESISTANCE IN PATIENTS WITH PREMATURE ADRENARCHE

Nurullah Çelik(CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-1583-6807
Gülşah Ünsal(CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ)
Pages
1–6
Publication Date
2023-01-31
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Therefore, additional evaluation for IR parameters in lean children with PA is not required.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: There is a conflicting result in terms of insulin resistance (IR) in children with Premature Adrenarche (PA).
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Key Findings & Data:Material and Methods: This cross-sectional study was conducted in a tertiary pediatric endocrinology clinic with 160 children aged 6-8 years old.
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Conclusion & Impact:Therefore, additional evaluation for IR parameters in lean children with PA is not required.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Premature Adrenarche · Insulin Resistance · Triglyceride Glucose index

Abstract

Purpose: There is a conflicting result in terms of insulin resistance (IR) in children with Premature Adrenarche (PA). The study aimed to investigate the IR and Trıglycerıde-Glucose (Ty-G) index in patıents wıth PA. Material and Methods: This cross-sectional study was conducted in a tertiary pediatric endocrinology clinic with 160 children aged 6-8 years old. The study group (n=75) were selected cases diagnosed with PA. Seventy-nine age and sex-matched children were also selected as a control group. Ty-G İndex, Homeostasis Model of Insulin Resistance (HOMA-IR), and atherogenic index of plasma (AIP) were calculated. Results: Trıglycerıde-Glucose index, AIP, and HOMA-IR were similar (p>0.05). Ty-G İndex was positively correlated with AIP (r=0.61, p<0.001), BMI-SDS (r=0.26, p=0.002), and HOMA-IR (r=0.33, p<0.001) levels. The DHEA-S level was correlated with the AIP (r=0.24, p=0.005), and BMI-SDS (r=0.17, p=0.03) levels. BMI-SDS was correlated wtih HOMA-IR (r=0.28, p=0.02) levels. Conclusion: Non-obese children with PA have similar IR parameters compared with control groups. Therefore, additional evaluation for IR parameters in lean children with PA is not required.

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Cite This Article

Çelik, N., Ünsal, G. (2023). EVALUATION OF INSULIN RESISTANCE IN PATIENTS WITH PREMATURE ADRENARCHE. Türk Fen ve Sağlık Dergisi, Cilt: 4 Sayı: 1, 1–6. https://doi.org/10.51972/tfsd.1144735

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