SavedAdd your journal

Journals / Türk Fen ve Sağlık Dergisi / 2026 / Cilt: 7 Sayı: 2

A Bibliometric Analysis of Chalcones with Antimicrobial Potential

Antimikrobiyal Potansiyele Sahip Kalkonların Bibliyometrik Analizi

Nisanur Pekgöz(SİVAS CUMHURİYET ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, BESLENME VE DİYETETİK BÖLÜMÜ)0009-0006-7759-5825
Gülay Demir(SİVAS CUMHURİYET ÜNİVERSİTESİ, SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU)0000-0002-3916-7639
Hayreddin Gezegen(SİVAS CUMHURİYET ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ FAKÜLTESİ, BESLENME VE DİYETETİK BÖLÜMÜ)0000-0003-3602-7400
Pages
69–88
Publication Date
2026-06-01
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the three-field graph, the top country is “Brazil,” the leading author parameter is “Bandeira Pn.,” and the keyword is “antimicrobial activity.”

📌 3 Key Takeaways

🎯
Objective & Hypothesis:ABSTRACT: Purpose: Chalcones are secondary metabolites that occur naturally in plants and cannot be synthesized in the human and animal body.
📊
Key Findings & Data:Its structure is 1,3-diaryl-2-propen-1-one and is the precursor of flavonoids.
💡
Conclusion & Impact:According to the three-field graph, the top country is “Brazil,” the leading author parameter is “Bandeira Pn.,” and the keyword is “antimicrobial activity.”
🔬Design:Review & Systematic Survey
📍Scope:2014 Verileri
⚙️Variables:Kalkonlar · Antimikrobiyal · Bibliyometrik Analiz

Abstract

ABSTRACT: Purpose: Chalcones are secondary metabolites that occur naturally in plants and cannot be synthesized in the human and animal body. Its structure is 1,3-diaryl-2-propen-1-one and is the precursor of flavonoids. It has many important activities such as antimicrobial, antidiabetic, antiviral, antifungal, anti-inflammatory, antituberculosis and antitumor. The aim of this study was to conduct first time a bibliometric analysis on chalcones and their antimicrobial effects. It aims to reveal the trends and main findings in the academic literature on this subject. Material and Methods: This article performs a detailed bibliometric analysis of the antimicrobial activity of chalcones using the Biblioshiny application from the Bibliometric package with the R program and the VOSviewer tool. The Scopus database was searched for 571 relevant articles published between 2014 and 2024. Results: India is the most important country, followed by Brazil and then China. The article “A Review: The Pharmacology of Isoliquiritigenin” by Peng et al. (2015) published in PHYTOTHER RES was the most contributing study with 222 citations. With 23 articles, JOURNAL OF MOLECULAR STRUCTURE is the most important journal and OSMANIA UNIVERSITY is the most important institution with 77 articles. Conclusion: 571 English-language publications on chalcones and antimicrobials were identified within the relevant time frame. The results were as follows: the average age of the articles was 5.18 years, and there were an average of 13.93 citations per document. Of the 2,447 authors, 13 were sole authors. International co-authorship accounted for 18.74% of all co-authored articles. According to the three-field graph, the top country is “Brazil,” the leading author parameter is “Bandeira Pn.,” and the keyword is “antimicrobial activity.”

Özet

ÖZET: Amaç: Kalkonlar, bitkilerde doğal olarak bulunan, insan ve hayvan vücudunda sentezlenemeyen sekonder metabolitlerdir. Yapısı 1,3-diaril-2-propen-1-on olup flavonoidlerin öncüsüdür. Antimikrobiyal, antidiyabetik, antiviral, antifungal, antiinflamatuar, antitüberküloz ve antitümör gibi birçok önemli aktiviteye sahiptir. Bu çalışmanın amacı, kalkonlar ve antimikrobiyal etkileri üzerine ilk kez bir bibliyometrik analiz yapmaktır. Bu çalışma, bu konudaki akademik literatürdeki eğilimleri ve temel bulguları ortaya koymayı amaçlamaktadır. Gereç ve Yöntemler: Bu makale, Bibliometrik paketinden Biblioshiny uygulamasını, R programını ve VOSviewer aracını kullanarak kalkonların antimikrobiyal aktivitesinin ayrıntılı bir bibliyometrik analizini gerçekleştirmektedir. Scopus veri tabanında 2014-2024 yılları arasında yayınlanmış 571 ilgili makale tarandı. Sonuçlar: Hindistan en önemli ülke olup, onu Brezilya ve Çin takip etmektedir. Peng ve ark. (2015) tarafından PHYTOTHER RES'te yayınlanan "A Review: The Pharmacology of Isoliquiritigenin" adlı makale, 222 atıf ile en çok katkıda bulunan çalışma olmuştur. 23 makale ile JOURNAL OF MOLECULAR STRUCTURE en önemli dergi, OSMANIA UNIVERSITY ise 77 makale ile en önemli kurumdur. Sonuç: İlgili zaman dilimi içinde kalkonlar ve antimikrobiyaller üzerine 571 İngilizce yayın tespit edildi. Sonuçlar şu şekildeydi: Makalelerin ortalama yaşı 5,18 yıldı ve belge başına ortalama 13,93 atıf vardı. 2.447 yazardan 13'ü tek yazardı. Uluslararası ortak yazarlık, tüm ortak yazarlı makalelerin %18,74'ünü oluşturuyordu. Üç alanlı grafiğe göre, en üst ülke "Brezilya", önde gelen yazar parametresi "Bandeira Pn." ve anahtar kelime "antimikrobiyal aktivite"dir

🔖

Cite This Article

Pekgöz, N., Demir, G., Gezegen, H. (2026). A Bibliometric Analysis of Chalcones with Antimicrobial Potential. Türk Fen ve Sağlık Dergisi, Cilt: 7 Sayı: 2, 69–88. https://doi.org/10.51972/tfsd.1800212

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (62)

  1. Achilonu, C. C., Udensi, O. U. (2022). Systematic review of antimicrobial activities of medicinal plants against bacterial and fungal microbes: a research trend in africa from 1980 to 2019. https://orcid.org/0000- 0002-3016-5004
  2. Anto, R. J., Sukumaran, K., Kuttan, G. et al. (1995). Anticancer and antioxidant activity of synthetic chalcones and related compounds. Cancer letters, 97(1), 33-37. https://doi.org/10.1016/0304- 3835(95)03945-S
  3. Aparicio-Martinez, P., Perea-Moreno, A. J., Martinez- Jimenez, M. P. et al. (2019). A bibliometric analysis of the health field regarding social networks and young people. International journal of environmental research and public health, 16(20), 4024. https://doi.org/10.3390/ijerph16204024
  4. Aydoğan, L., Deveci, K. Laparotomi Uygulanan Siçanlarda Kalkon-İmid Kullaniminin Oksidatif Stres Üzerine Etkisinin Değerlendirilmesi. Gaziosmanpaşa Bilimsel Araştırma Dergisi, 13(2), 31-38. http://dergipark.gov.tr/gbad
  5. Baş, H. (2023). Beyin Göçüne İlişkin Yayınların VOSviewer ile Bibliyometrik Analizi. Toplumsal Politika Dergisi, 4(1), 52-65.
  6. Bashar, A., Singh, S., Pathak, V. K. (2022). A bibliometric review of online impulse buying behaviour. International Journal of Electronic Business, 17(2), 162-183. https://doi.org/10.1504/IJEB.2022.121963
  7. Cardona-Galeano, W., Ramirez-Malule, H., Gómez-Ríos, D. (2023). Hybrids based on coumarins and their anticancer activities: A bibliometric analysis. Journal of Applied Pharmaceutical Science, 13(9), 204-212. https://dx.doi.org/10.7324/JAPS.2023.150232
  8. Chaudhary, S. K., Sandasi, M., Makolo, F. et al. (2021). Aspalathin: A rare dietary dihydrochalcone from Aspalathus linearis (rooibos tea). Phytochemistry Reviews, 1-32. https://doi.org/10.1007/s11101-021-09741-9
  9. Cheng, K., Zhang, H., Guo, Q. et al. (2022). Emerging trends and research foci of oncolytic virotherapy for central nervous system tumors: A bibliometric study. Frontiers in immunology, 13, 975695. https://doi.org/10.3389/fimmu.2022.975695
  10. Chu, J., & Guo, C. L. (2016). Design and Discovery of Some Novel Chalcones as Antioxidant and Anti‐Inflammatory Agents via Attenuating NF‐κB. Archiv der Pharmazie, 349(1), 63-70. https://doi.org/10.1002/ardp.201500349
  11. Claisen, L., & Claparede, A. (1881). Condensationen von ketonen mit aldehyden. Berichte der deutschen chemischen Gesellschaft, 14(2), 2460-2468. DOI: 10.1002/cber.188101402192
  12. Coelho, C. B., Alves, C. D. S. C., Tavares, Y. K. S. C. et al. (2024). Healing effect of medicinal plant extracts in Northeast Brazil: A systematic review on phytochemistry and preclinical studies. Phytochemistry Letters, 62, 6-13. https://doi.org/10.1016/j.phytol.2024.05.013
  13. Demir, G., Chatterjee, P., Zakeri, S. et al. (2024c). Mapping the Evolution of Multi-Attributive Border Approximation Area Comparison Method: A Bibliometric Analysis. Decision Making: Applications in Management and Engineering, 7(1), 290–314. https://doi.org/10.31181/dmame7120241037
  14. Demir, G., Chatterjee, P., Kadry, S. et al. (2024b). Measurement of Alternatives and Ranking according to Compromise Solution (MARCOS) Method: A Comprehensive Bibliometric Analysis. Decision Making: Applications in Management and Engineering, 7(2), 313-336. https://doi.org/10.31181/dmame7220241137
  15. Demir, G., Chatterjee, P., Pamucar, D. (2024a). Sensitivity analysis in multi-criteria decision making: A state-ofthe- art research perspective using bibliometric analysis. Expert Systems with Applications, 237, 121660. https://doi.org/10.1016/j.eswa.2023.121660
  16. Donthu, N., Kumar, S., Mukherjee, D. et al. (2021). How to conduct a bibliometric analysis: An overview and guidelines. Journal of business research, 133, 285-296. https://doi.org/10.1016/j.jbusres.2021.04.070
  17. Dos Santos, A. T. L., de Araújo-Neto, J. B., da Silva, M. M. C. et al. (2023). Synthesis of chalcones and their antimicrobial and drug potentiatingactivities. Microbial Pathogenesis, 180, 106129.https://doi.org/10.1016/j.micpath.2023.106129
  18. Elbatreek, M. H., Mahdi, I., Ouchari, W. et al. (2023). Current advances on the therapeutic potential of pinocembrin: an updated review. Biomedicine & Pharmacotherapy, 157, 114032.https://doi.org/10.1016/j.biopha.2022.114032
  19. Fatima, M., Dar, M. A., Dhanavade, M. J. et al. (2024). Biosynthesis and pharmacological activities of the bioactive compounds of white mulberry (Morus alba): Current Paradigms and Future Challenges. Biology, 13(7), 506. https://doi.org/10.3390/biology13070506
  20. Ferreira, F. A., Santos, S. P. (2021). Two decades on the MACBETH approach: A bibliometric analysis. Annals of Operations Research, 296, 901-925. https://doi.org/10.1007/s10479-018-3083-9
  21. Ferreira, M. K. A., da Silva, A. W., dos Santos Moura, A. L. et al. 2021). Chalcones reverse the anxiety and convulsive behavior of adult zebrafish. Epilepsy & Behavior, 117, 107881.https://doi.org/10.1016/j.yebeh.2021.107881
  22. Ferreira, M. K. A., Freitas, W. P. O., Barbosa, I. M. et al. (2023). Heterocyclic chalcone (E)-1-(2-hydroxy-3, 4, 6- trimethoxyphenyl)-3-(thiophen-2-yl) prop-2-en-1-one derived from a natural product with antinociceptive, anti-inflammatory, and hypoglycemic effect in adult zebrafish. 3 Biotech, 13(8), 276. https://doi.org/10.1007/s13205-023-03696-8
  23. Girisa, S., Saikia, Q., Bordoloi, D. et al. (2021). Xanthohumol from Hop: Hope for cancer prevention and treatment. IUBMB life, 73(8), 1016-1044. https://doi.org/10.1002/iub.2522
  24. Gomes, M. N., Muratov, E. N., Pereira, M. et al. (2017). Chalcone derivatives: promising starting points for drug design. Molecules, 22(8), 1210. https://doi.org/10.3390/molecules22081210
  25. Guan, L. P., Zhao, D. H., Chang, Y. et al. (2013). Synthesis of 2, 4-dihydroxychalcone derivatives as potential antidepressant effect. Drug research, 63(01), 46-51. https://doi.org/10.1055/s-0032-1333229
  26. Han, Q., Li, Z., Fu, Y. et al. (2023). Analyzing the research landscape: mapping frontiers and hot spots in anticancer research using bibliometric analysis and research network pharmacology. Frontiers in Pharmacology, 14, 1256188. https://doi.org/10.3389/fphar.2023.1256188
  27. Hassan, M. K., Alshater, M. M., Rashid, M. et al. (2022). Ten years of the Journal of Islamic Marketing: a bibliometric analysis. Journal of Islamic Marketing, 13(10), 2047-2068. https://doi.org/10.1108/JIMA-10-2020-0322
  28. Kim, Y. J., Qian, L., Aslam, M. S. (2021). Bibliographic analysis of Clinacanthus nutans papers in Scopus database (2000–2019). https://doi.org/10.12688/f1000research.52946.1
  29. Krawczyk-Łebek, A., Żarowska, B., Janeczko, T. et al. (2024). Antimicrobial Activity of Chalcones with a Chlorine Atom and Their Glycosides. International Journal of Molecular Sciences, 25(17), 9718. https://doi.org/10.3390/ijms25179718
  30. Kudličková, Z., Michalková, R., Salayová, A. et al. (2023). Design, synthesis, and evaluation of novel indole hybrid chalcones and their antiproliferative and antioxidant activity. Molecules, 28(18), 6583. https://doi.org/10.3390/molecules28186583
  31. Kumar, H., Devaraji, V., Joshi, R. et al. (2015). Antihypertensive activity of a quinoline appended chalcone derivative and its site specific binding interaction with a relevant target carrier protein. RSC advances, 5(80), 65496-65513. https://doi.org/10.1039/C5RA08778C
  32. Kyogoku, K., Hatayama, K., Yokomorı, S. et al. (1979). Antiulcer effect of isoprenyl flavonoids. II. Synthesis and anti-ulcer activity of new chalcones related to sophoradin. Chemical and pharmaceutical bulletin, 27(12), 2943-2953. https://doi.org/10.1248/cpb.27.2943
  33. Li, R., Kenyon, G. L., Cohen, F. E. et al. (1995). In vitro antimalarial activity of chalcones and their derivatives. Journal of medicinal chemistry, 38(26), 5031-5037.
  34. Lin, Y. M., Zhou, Y., Flavin, M. T. et al. (2002). Chalcones and flavonoids as anti-tuberculosis agents. Bioorganic & medicinal chemistry, 10(8), 2795-2802. https://doi.org/10.1016/S0968-0896(02)00094-9
  35. Machado, J. A., Araújo, D. B., Lima-Maximino, M. et al. (2024). Flavonoids as anxiolytics in animal tests: Bibliometry and meta-analysis of the effects of flavonoids on anxiety-like behavior in animal tests. bioRxiv, 2024-05. https://doi.org/10.1101/2024.05.27.596117
  36. Mannino, G., Gentile, C., Ertani, A. et al. (2021). Anthocyanins: Biosynthesis, distribution, ecological role, and use of biostimulants to increase their content in plant foods—A review. Agriculture, 11(3), 212. https://doi.org/10.3390/agriculture11030212
  37. Marotta, L., Rossi, S., Ibba, R. et al. (2022). The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery. Frontiers in chemistry, 10, 988376. https://doi.org/10.3389/fchem.2022.988376
  38. Martín-Martín, A., Orduna-Malea, E., Thelwall, M. et al. (2018). Google Scholar, Web of Science, and Scopus: A systematic comparison of citations in 252 subject categories. Journal of informetrics, 12(4), 1160-1177. https://doi.org/10.1016/jjoi.2018.09.002
  39. Matos, M. J., Vazquez-Rodriguez, S., Uriarte, E., & Santana, L. (2015). Potential pharmacological uses of chalcones: a patent review (from June 2011– 2014). Expert opinion on therapeutic patents, 25(3), 351-366. https://doi.org/10.1517/13543776.2014.995627
  40. Mazumder, A., Wang, S., Neamati, N., Nicklaus, M. et al. (1996). Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease. Journal of medicinal chemistry, 39(13), 2472-2481.https://pubs.acs.org/doi/10.1021/jm960074e
  41. Muñoz-Acevedo, A., González, M. C., Castillo, O. J. et al. (2022). Promising antimicrobial agents from some Latin American medicinal plants against diseasecausing pathogens in humans and animals. In Promising Antimicrobials from Natural Products (pp. 241-279). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-030-83504-0_11
  42. Nematollahi, M. H., Mehrabani, M., Hozhabri, Y. et al. (2023). Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis. Heliyon, 9(10), e20428. https://doi.org/10.1016/j.heliyon.2023.e20428
  43. Nguyen, D. V., Muanprasat, C., Kaewin, S. et al. (2024). Synthesis and biological evaluation of 2′- hydroxychalcone derivatives as AMPK activators. Bioorganic Chemistry, 143, 107048. https://doi.org/10.1016/j.bioorg.2023.107048
  44. Nowakowska, Z. (2007). A review of anti-infective and anti-inflammatory chalcones. European journal of medicinal chemistry, 42(2), 125-137.
  45. Poerwono, H., Rudyanto, M. (2023). Bibliometric Study of Microwave-Assisted Synthesis of Flavanone Derivatives. Borneo Journal of Pharmacy, 6(4), 339- 348. https://doi.org/10.33084/bjop.v6i4.5602
  46. Ponticelli, M., Bellone, M. L., Parisi, V. et al. (2023). Specialized metabolites from plants as a source of new multi-target antiviral drugs: a systematic review. Phytochemistry Reviews, 22(3), 615-693. https://doi.org/10.1007/s11101-023-09855-2
  47. Reddy, M. V. B., Shen, Y. C., Ohkoshi, E. et al. (2012). Bischalcone analogues as potent NO production inhibitors and as cytotoxic agents. European journal of medicinal chemistry, 47, 97-103. https://doi.org/10.1016/j.ejmech.2011.10.026
  48. Rocha, S., Sousa, A., Ribeiro, D. et al. (2019). A study towards drug discovery for the management of type 2 diabetes mellitus through inhibition of the carbohydrate-hydrolyzing enzymes α-amylase and α- glucosidase by chalcone derivatives. Food & function, 10(9), 5510-5520. https://doi.org/10.1039/c9fo90045d
  49. Schmidt, J. G. (1881). Ueber die Einwirkung von Aceton auf Furfurol und auf Bittermandelöl bei Gegenwart von Alkalilauge. Berichte der deutschen chemischen Gesellschaft, 14(1), 1459-1461. https://doi.org/10.1002/cber.188101401306
  50. Shaik, A., Bhandare, R. R., Palleapati, K. et al. (2020). Antimicrobial, antioxidant, and anticancer activities of some novel isoxazole ring containing chalcone and dihydropyrazole derivatives. Molecules, 25(5), 1047. https://doi.org/10.3390/molecules25051047
  51. Sharma, R., Kumar, R., Kodwani, R. et al. (2016). A review on mechanisms of anti tumor activity of chalcones. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 16(2), 200-211. http://dx.doi.org/10.2174/1871520615666150518093144
  52. Tıwarı, A., Tıwarı, A. (2024). Flavonoids in Acacia catechu bark extracts and bibliographic analysis in Guna, Madhya Pradesh, India. Int J Pharm Pharm Sci, 16(6), 46-55.https://dx.doi.org/10.22159/ijpps.2024v16i6.50939
  53. Tsukiyama, R. I., Katsura, H., Tokuriki, N. et al. (2002). Antibacterial activity of licochalcone A against sporeforming bacteria. Antimicrobial agents and chemotherapy, 46(5), 1226-1230. https://doi.org/10.1128/aac.46.5.1226-1230.2002
  54. Van Eck, N. J., Waltman, L. (2017). Citation-based clustering of publications using CitNetExplorer and VOSviewer. Scientometrics, 111(2), 1053-1070. https://doi.org/10.1007/s11192-017-2300-7
  55. Van Eck, N., Waltman, L. (2010). Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 84(2), 523-538. https://doi.org/10.1007/s11192-009-0146-3
  56. Wilson, M., Sampson, M., Barrowman, N. et al. (2021). Bibliometric analysis of neurology articles published in general medicine journals. JAMA Network Open, 4(4), e215840-e215840. doi:10.1001/jamanetworkopen.2021.5840.
  57. Yepes, A. F., Galeano, W. C., Ramírez-Malule, H. (2024). Scientific landscape of melatonin, its hybrids, and its derivatives as anti-tumor agents: A bibliometric analysis. Journal of Applied Pharmaceutical Science, 14(10), 205-218. https://dx.doi.org/10.7324/JAPS.2024.169632
  58. Yeung, A. W. K., Aggarwal, B. B., Orhan, I. E. et al. (2019). Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis-a review. Animal Science Papers and Reports, 37(2), 103-118. http://eprints.bmsu.ac.ir/id/eprint/2816
  59. Yeung, A. W. K., Solka, M., Jóźwik, A. et al. (2024). Anthocyanins-dietary natural products with a variety of bioactivities for the promotion of human and animal health. Animal Science Papers and Reports, 42(1), 5- 34. https://doi.org/10.2478/aspr-2023-0020
  60. Yücel, T. B., Fandaklı, S., Demir, İ. vd. (2023). 2-, 3-, 4- Bromo azaflavanonların amino kalkonlardan katı faz ortamında mikrodalga destekli sentezi, antimikrobiyal ve antioksidan aktivitelerinin tayini. Journal of Advanced Research in Natural and Applied Sciences, 9(2), 465-476. https://doi.org/10.28979/jarnas.1174437
  61. Zhang, H., Gao, Y., Fu, G. et al. (2023). Trends and hotspots for European Journal of Medicinal Chemistry: A bibliometric study. European Journal of Medicinal Chemistry, 247, 115041. https://doi.org/10.1016/j.ejmech.2022.115041
  62. Zhuang, C., Zhang, W., Sheng, C. et al. (2017). Chalcone: a privileged structure in medicinal chemistry. Chemical reviews, 117(12), 7762-7810. https://doi.org/10.1021/acs.chemrev.7b00020