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Journals / Turkish Journal of Analytical Chemistry / 2022 / Cilt: 4 Sayı: 2

Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer

Esra Bağda(SIVAS CUMHURIYET UNIVERSITY, FACULTY OF PHARMACY, PHARMACY PR.)0000-0003-1900-4944
Rümeysa Durak(SIVAS CUMHURIYET UNIVERSITY)0000-0001-8345-3248
Efkan Bağda(SIVAS CUMHURIYET UNIVERSITY)0000-0002-3925-3430
Didem Duman(SIVAS CUMHURIYET UNIVERSITY)0000-0002-0900-0336
Ebubekir Ayhan(SIVAS CUMHURIYET UNIVERSITY)0000-0002-5371-8425
Pages
116–122
Publication Date
2022-12-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Etkileşimlerin varlığı, yüksek hassasiyetli LED kaynaklı floresan dedektör Qsep100 kapiler jel elektroforez sistemi kullanılarak DNA polimeraz durdurma testi ile desteklenmiştir.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Artan metabolik aktivite ve metastaz, kanser hücrelerinin ana ve en bilinen özellikleridir.
📊
Key Findings & Data:Hücrelerin artan aktivitesi, G-dörtlü yapıların oluşumunda artışa neden olur.
💡
Conclusion & Impact:Etkileşimlerin varlığı, yüksek hassasiyetli LED kaynaklı floresan dedektör Qsep100 kapiler jel elektroforez sistemi kullanılarak DNA polimeraz durdurma testi ile desteklenmiştir.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:G-quadruplex DNA · As1411 · Bismarck brown Y

Abstract

Artan metabolik aktivite ve metastaz, kanser hücrelerinin ana ve en bilinen özellikleridir. Hücrelerin artan aktivitesi, G-dörtlü yapıların oluşumunda artışa neden olur. G-quadruplex'in çeşitli ligandlarla stabilizasyonu veya destabilizasyonu, hücre proliferasyonunda bozulmalara neden olabilir. Dolayısıyla, bu ikincil yapının stabilizasyonu veya destabilizasyonu önemli antikanser ilaç hedefleridir. Bu çalışmada, Bismarck kahverengi Y-Pd kompleksi, kolay, tek aşamalı bir karıştırma yöntemiyle oluşturulmuştur. Kompleksin spektral özellikleri ve stokiyometrisi, Uv-vis spektrofotometrik olarak araştırıldı. 1:2, Bismarck Brown Y-Pd kompleksinin AS1411 G-dörtlü yapı ile etkileşimi spektrofotometrik titrasyon ile araştırıldı. Bağlanma sabitleri hesaplandı ve 4.38 (±1.96) x104 M-1 olarak bulundu. Kompleksin G-dörtlü konformasyon üzerindeki etkisi CD spektroskopisi ile araştırıldı. Etkileşimlerin varlığı, yüksek hassasiyetli LED kaynaklı floresan dedektör Qsep100 kapiler jel elektroforez sistemi kullanılarak DNA polimeraz durdurma testi ile desteklenmiştir.

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Cite This Article

Bağda, E., Durak, R., Bağda, E., Duman, D., Ayhan, E. (2022). Investigation of Interaction of Bismarck Brown Y- Palladium Complex with AS1411 G-quadruplex Aptamer. Turkish Journal of Analytical Chemistry, Cilt: 4 Sayı: 2, 116–122. https://doi.org/10.51435/turkjac.1203081

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