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Journals / Turkish Computational and Theoretical Chemistry / 2022 / Volume: 6 Issue: 2

Investigation of Antiparasitic Properties of Benzimidazole Derivatives Against Amebiasis

Ahmet Duran Ataş(SIVAS CUMHURIYET UNIVERSITY)0000-0002-6274-414X
Hilmi Ataseven(SIVAS CUMHURIYET UNIVERSITY)0000-0001-5458-509X
Koray Sayın(Department of Chemistry, Faculty of Science, Sivas Cumhuriyet University 58140 Sivas/TURKEY)0000-0001-6648-5010
Pages
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Publication Date
2022-12-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Pantoprazole was clinged to Entamoeba histolytica to inhibiting it.

📌 3 Key Takeaways

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Objective & Hypothesis:Entamoeba histolytica is one of the common causes of infection in humans around the world.
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Key Findings & Data:It causes clinically significant infection due to the fact that it causes morbidity and mortality.
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Conclusion & Impact:Pantoprazole was clinged to Entamoeba histolytica to inhibiting it.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Proton Pump Inhibitors · Parasite · Entamoeba Histolytica

Abstract

Entamoeba histolytica is one of the common causes of infection in humans around the world. It causes clinically significant infection due to the fact that it causes morbidity and mortality. There is a need for new and safe drugs in the treatment of amebiasis. In this study, the activity of proton pump inhibitors against this parasite were investigated. Pantoprazole, lansoprazole, omeprazole, esomeprazole and rabeprazole were examined in detail. Initially, related drugs are optimized at M062X/6-31+G(d) level in water. Then, 3JS5, 3IDO and 3ILY were minimized at OPLS3e method. The docking calculations were performed and it is found that pantoprazole could be a significant candidate in the inhibiting of Entamoeba histolytica. Then, the interaction between pantoprazole and the target parasite were examined in the range of 0 – 100 nanoseconds (ns). The interaction energies in each one ns were calculated. As a result, the interaction was found as stronger than 88 ns. Pantoprazole was clinged to Entamoeba histolytica to inhibiting it.

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Cite This Article

Ataş, A. D., Ataseven, H., Sayın, K. (2022). Investigation of Antiparasitic Properties of Benzimidazole Derivatives Against Amebiasis. Turkish Computational and Theoretical Chemistry, Volume: 6 Issue: 2. https://doi.org/10.33435/tcandtc.1055649

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References (5)

  1. C. Marie, W.A. Petri Jr, Amoebic dysentery, BMJ Clin Evid. 8 (2013) 918.
  2. S. Saidin, N. Othman, R. Noordin, Update on laboratory diagnosis of amoebiasis, European Journal of Clinical Microbiology & Infectious Diseases 38 (2019) 15–38.
  3. J. C. Carrero, M. Reyes-López, J. Serrano-Luna, M. Shibayama, J. Unzueta, N. Leon-Sicairos, M. de la Garza, Intestinal amoebiasis: 160 years of its first detection and still remains as a health problem in developing countries, Int J Med Microbiol. 310 (2020) 151358.
  4. G. M. Ehrenkaufer, S. Suresh, D. Solow-Cordero, U. Singh, High-Throughput Screening of Entamoeba Identifies Compounds Which Target Both Life Cycle Stages and Which Are Effective Against Metronidazole Resistant Parasites, Front. Cell. Infect. Microbiol., 8 (2018) 276.
  5. S. Erkan, K. Sayın, Chemistry of Proton Pump Inhibitors - Proton Pompa İnhibitörlerinin Kimyası. Ed: Hilmi Ataseven, Merve Ergül. Her Yönüyle Proton Pompaları ve Proton Pompa İnhibitörleri, Cumhuriyet Üniversitesi Yayınları. Sivas (2020) 63-80.