SavedAdd your journal

Journals / Sabuncuoglu Serefeddin Health Sciences / 2026 / Cilt: 6 Sayı: 1

Investigation of Neopterin Levels in Children with Hashimoto Thyroiditis

Burhan Ertekin(GAZIOSMANPASA UNIVERSITY)0000-0003-2804-047X
Hacı Ömer Ateş(TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ)0000-0003-4266-393X
Pages
1–10
Publication Date
2024-08-30
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In the study, when the individuals with Hashimoto's Thyroiditis between the ages of 5-18 were compared with the control group individuals in the same age range, no statistically significant difference ( p>0.05 ) was found between the neopterin levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:ABSTRACT Objective: Hashimoto Thyroiditis is an autoimmune disease caused by genetic and environmental factors and is known as the most common cause of hypothyroidism in childhood.
📊
Key Findings & Data:The aim of this study was to investigate the autoimmune association of neopterin in patients with Hashimoto's Thyroiditis aged 5-18 years.
💡
Conclusion & Impact:Conclusion: In the study, when the individuals with Hashimoto's Thyroiditis between the ages of 5-18 were compared with the control group individuals in the same age range, no statistically significant difference ( p>0.05 ) was found between the neopterin levels.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Hashimoto Thyroiditis · ELISA · Neopterin

Abstract

ABSTRACT Objective: Hashimoto Thyroiditis is an autoimmune disease caused by genetic and environmental factors and is known as the most common cause of hypothyroidism in childhood. Neopterin has been measured in many autoimmune disorders and has been identified as a marker of cellular immune activation. The aim of this study was to investigate the autoimmune association of neopterin in patients with Hashimoto's Thyroiditis aged 5-18 years. Material and Method: Neopterin levels were measured in 80 individuals, 40 of whom were followed up with the diagnosis of Hashimoto Thyroiditis and 40 of whom were not diagnosed with Hashimoto Thyroiditis. Results: While the mean value of neopterin levels in the control group participating in this study was 86.4170 ± 3.59284, the mean value in the patient group was 101.32 ± 9.75378. When we look at the participant age data, it is seen that the patients and controls are compatible with each other (p>0.05). In addition, it is seen that there is a significant positive correlation p<0.05 between the variables of age-neopterin levels and tsh-neopterin levels. Conclusion: In the study, when the individuals with Hashimoto's Thyroiditis between the ages of 5-18 were compared with the control group individuals in the same age range, no statistically significant difference ( p>0.05 ) was found between the neopterin levels.

🔖

Cite This Article

Ertekin, B., Ateş, H. Ö. (2024). Investigation of Neopterin Levels in Children with Hashimoto Thyroiditis. Sabuncuoglu Serefeddin Health Sciences, Cilt: 6 Sayı: 1, 1–10. https://doi.org/10.55895/sshs.1322928

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Barić, A., Brčić, L., Gračan, S., Torlak Lovrić, V., Gunjača, I., Šimunac, M., Brekalo, M., Boban, M., Polasek, O., Barbalic, M., Zemunik, T., Punda, A., & Boraska Perica, V. (2017). Association of established hypothyroidism-associated genetic variants with Hashimoto’s thyroiditis. J Endocrinol Invest, 40, 1061-1067. doi: 10.1007/s40618-017-0660-8
  2. Baydar, T., Palabiyik, S., Sahin, G. (2009). Neopterin: Günümüzün Popüler Biyogöstergesi mi? Türkiye Klinikleri Tıp Bilimleri Dergisi, 29(5), 1280-1291.
  3. Berdowska, A. & Zwirska‐Korczala, K. (2001). Neopterin measurement in clinical diagnosis. J Clin Pharm Ther., 26(5), 319-329. doi: 10.1046/j.1365-2710.2001.00358.x
  4. Eisenhut, M. (2013). Neopterin in diagnosis and monitoring of infectious diseases. J Biomark., 2013(1), 196432. doi: 10.1155/2013/196432
  5. Fuchs, D., Avanzas, P., Arroyo-Espliguero, R., Jenny, M., Consuegra-Sanchez, L., & Kaski, J. C. (2009). The role of neopterin in atherogenesis and cardiovascular risk assessment. Curr Med Chem., 16(35), 4644-4653. doi: 10.2174/092986709789878247
  6. Gülkesen, A., Akgöl, G., Tuncer, T., Kal, G. A., Selda, T., Poyraz, A. K., & Arzu, K. (2016). Relationship between leptin and neopterin levels and disease activation parameters in patients with rheumatoid arthritis. Arch Rheumatol., 31(4), 333. doi: 10.5606/ArchRheumatol.2016.5893
  7. Hamerlinck, F. F. (1999). Neopterin: a review. Exp Dermatol, 8(3), 167-176. doi: 10.1111/j.1600-0625.1999.tb00367.x Kondera-Anasz, Z., & Mertas, A. (1999). Level of serum neopterin and interleukin-6 in patients with thyroid diseases. Pteridines, 10(4), 197-201. doi.org/10.1515/pteridines.1999.10.4.197
  8. Liontiris, M. I., & Mazokopakis, E. E. (2017). A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients. Points that need more investigation. Hell J Nucl Med., 20(1), 51-56. doi: 10.1967/s002449910507
  9. Michalak, Ł., Bulska, M., Strząbała, K., & Szcześniak, P. (2017). Neopteryna jako marker komórkowej odpowiedzi immunologicznej. Postepy Hig Med Dosw., 71, 727-736.doi: 10.5604/01.3001.0010.3851
  10. Mutluay, R., & Yeğin, Z. A. (2003). Hashimoto Tiroiditi (Kronik Lenfositik Tiroidit, Struma Lymphomatosa)
  11. Plata-Nazar, K., Szumera, M., Łuczak, G., Liberek, A., Sznurkowska, K., Szlagatys-Sidorkiewicz, A., Lange, M., & Kamińska, B. (2015). Clinical usefulness of serum neopterin in children with juvenile idiopathic arthritis. Pteridines, 26(2), 69-72. doi: 10.1515/pterid-2015-0003
  12. Wagner, R., Hayatghebi, S., Rosenkranz, M., & Reinwein, D. (1993). Increased serum neopterin levels in patients with Graves' disease. Exp Clin Endocrinol, 101(04), 249-254. doi: 10.1055/s-0029-1211240
  13. Zdraveska, N., & Kocova M. (2012). Hashimoto thyroiditis in childhood–review of the epidemiology, genetic susceptibility and clinical aspects of the disease.Macedonian Journal of Medical Sciences, 5(3), 336-345. doi: 10.3889/MJMS.1857-5773.2012.0247