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Journals / Epilepsi / 2018 / Cilt: 24 - Sayı: 1

Is Cardiac Repolarization Time Different Between Epilepsy Patients On Antiepileptic Drugs and Healthy Subjects?

Antiepileptik Kullanan Epilepsi Hastalarında İnteriktal Kardiyak Repolarizasyon Süresi Sağlıklı Bireylerden Farklı Mıdır?

Kezban ASLAN
ALİ DENİZ
TURGAY DEMİR
Buğra KARAASLAN
Hacer BOZDEMİR
Journal
Epilepsi
Pages
15–20
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results showed the importance of ECG controls at follow-up of epilepsy patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Sudden unexpected death in epilepsy (SUDEP) is attributed to peri-ictal cardiopulmonary abnormalities.
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Key Findings & Data:Methods: Seventy eight (51.3% females) epilepsy patients with a mean age of 32.7±11.4 (range, 17–63) years and 71 (56.3% female) healthy subjects with a mean age of 36.3±13.6 (range, 18–64) years participated in the study.
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Conclusion & Impact:These results showed the importance of ECG controls at follow-up of epilepsy patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Sudden unexpected death in epilepsy (SUDEP) is attributed to peri-ictal cardiopulmonary abnormalities. In the present study, epilepsy patients on monotherapy (carbamazepine [CBZ], oxcarbazepine [OXZ], valproic acid [VPA]) were compared with a healthy control group to investigate the effects of epilepsy and various antiepileptic drugs on QTmax, QTmin, and QTd. Methods: Seventy eight (51.3% females) epilepsy patients with a mean age of 32.7±11.4 (range, 17–63) years and 71 (56.3% female) healthy subjects with a mean age of 36.3±13.6 (range, 18–64) years participated in the study. The shorter and longer QT were measured by electrocardiography (ECG) and then differences between them (QTd) were calculated. SPSS for Windows 21.0 package software was used to compare the findings between groups. Results: QTmin (p<0.000), QTmax (p<0.000), and QTd (p=0.069) were longer in the epilepsy group than in the control group. On the other hand, we found that 20 epilepsy patients, and none of the control subjects, had a long QT. Conclusion: In this study, we found that cardiac repolarization parameters were different between epileptic and healthy subjects. These results showed the importance of ECG controls at follow-up of epilepsy patients.

Özet

Amaç: Epilepsi hastalarında ani kardiyak ölüm (SUDEP), peri-iktal ani kardiyopulmoner anormallikler sonucu gelişmektedir. Bu çalışmada monoterapi (karbamazepin [KBZ], okskarbazepin [OKZ], valproik asit [VPA]) alan epilepsi hastalarında QTmin, QTmax ve QTd değerlerini sağlıklı kontrol grubu ile karşılaştırarak, epilepsi ya da farklı antiepileptik ilaçların bu parametreler üzerindeki etkisini araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya, antiepileptik ilaç olarak monoterapi kullanan epilepsi tanılı yaş ortalaması 32.7±11.4 (dağılım, 17–63 yıl) olan 78 (%51.3’ü kadın) hasta ve yaş ortalaması 36.3±13.6 (dağlım, 18-64 yıl) olan 71 (%56.3’ü kadın) sağlıklı birey dahil edildi. Elektrokardiyografide (EKG); en uzun ve en kısa QT intervalleri manuel olarak ölçüldü (QTmax, QTmin). Daha sonra her ikisi arasındaki fark (QTd) hesaplandı. Veriler “SPSS for Windows 21.0” paket programı kullanılarak gruplar karşılaştırıldı. Bulgular: QTmin, QTmax ve QTd hasta grubunda, kontrol grubuna göre daha uzundu (p<0.000, p<0.000, p=0.069, sırası ile). Ayrıca hasta grubunda 20 olguda uzun QT değerinin olduğu, sağlıklı hiç bir bireyde ise uzun QT olmadığı saptandı. Sonuç: Bu çalışma sonucunda, antiepileptik ilaç kullanan epilepsi hastalarında, kardiyak repolarizasyon parametrelerinin sağlıklı bireylerden farklı olduğu belirlendi. Bu nedenle epilepsi hastalarında takipler sırasında EKG değerlendirmesinin önemli olduğu görülmektedir.

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Cite This Article

ASLAN, K., DENİZ, A., DEMİR, T., KARAASLAN, B., BOZDEMİR, H. (2018). Is Cardiac Repolarization Time Different Between Epilepsy Patients On Antiepileptic Drugs and Healthy Subjects?. Epilepsi, Cilt: 24 - Sayı: 1, 15–20. https://ajindex.com/articles/153567

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