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Journals / E Journal of Cardiovascular Medicine / 2019 / Cilt: 7 - Sayı: 2

The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats

İSMAİL POLAT CANBOLAT
Türker ÇAVUŞOĞLU
Gürkan YİĞİTTÜRK
Utku ATEŞ
Oytun ERBAS
Pages
84–88
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As the prevalence of diabetes mellitus is increasing, resveratrol supplementation could help preventing diabetic cardiomyopathy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: We aimed to investigate the effect of resveratrol on diabetic cardiomyopathy in streptozocininduced diabetic rats.
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Key Findings & Data:After four weeks, heart tissues were collected for histopathological examination and immunoexpression of nitric oxide synthases-2 (NOS-2) and transforming growth factor-β1 (TGF-β1).
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Conclusion & Impact:As the prevalence of diabetes mellitus is increasing, resveratrol supplementation could help preventing diabetic cardiomyopathy.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: We aimed to investigate the effect of resveratrol on diabetic cardiomyopathy in streptozocininduced diabetic rats. Materials and Methods: Rats were injected with streptozocin to establish diabetes model. After four weeks, heart tissues were collected for histopathological examination and immunoexpression of nitric oxide synthases-2 (NOS-2) and transforming growth factor-β1 (TGF-β1). Lipid peroxidation was evaluated. Results: In diabetic rats, cardiac muscle cell thickness (hypertrophy), TGF-β1 and NOS-2 expression were increased significantly when compared to control group. Administration of resveratrol in diabetic rats causes a significant reduction both in cardiac muscle cell thickness, TGF-β1 and NOS-2 expression in these rats. Blood glucose levels were significantly increased in diabetic rats expectedly, but there was no important difference between diabetic rats and resveratrol administrated diabetic rats in terms of blood glucose levels. Conclusion: We showed protective effects of resveratrol on dilated cardiomyopathy on diabetic rats by reducing oxidative stress. As the prevalence of diabetes mellitus is increasing, resveratrol supplementation could help preventing diabetic cardiomyopathy.

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Cite This Article

CANBOLAT, İ. P., ÇAVUŞOĞLU, T., YİĞİTTÜRK, G., ATEŞ, U., ERBAS, O. (2019). The Protective Role of Resveratrol on Diabetic Cardiomyopathy in Streptozocin Induced Diabetic Rats. E Journal of Cardiovascular Medicine, Cilt: 7 - Sayı: 2, 84–88. https://ajindex.com/articles/153511

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