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Journals / Astım Allerji İmmünoloji / 2014 / Cilt: 12 - Sayı: 3

Should radiotherapy and phenytoin not be given concurrently? EMPACT syndrome

Radyoterapi ve fenitoin birlikte verilmemeli mi? EMPACT sendromu

Emek KOCATÜRK
Utkan KIZILTAÇ
ŞULE GÜNGÖR
Bachar MEMET
Tülin YÜKSEL
Pages
175–179
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here, we report two cases of EMPACT syndrome associated with prophylactic use of phenytoin during cranial radiation therapy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:EMPACT syndrome is an erythema multiforme like cu- taneus eruption which is seen in patients who receive radiotherapy and phenytoin therapy concurrently for their intracranial malignity.
📊
Key Findings & Data:Seizures are the most frequent complication of intracranial malignities (primary and metastatic) which almost always need anticonvulsant therapy.
💡
Conclusion & Impact:Here, we report two cases of EMPACT syndrome associated with prophylactic use of phenytoin during cranial radiation therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

EMPACT syndrome is an erythema multiforme like cu- taneus eruption which is seen in patients who receive radiotherapy and phenytoin therapy concurrently for their intracranial malignity. Seizures are the most frequent complication of intracranial malignities (primary and metastatic) which almost always need anticonvulsant therapy. Here, we report two cases of EMPACT syndrome associated with prophylactic use of phenytoin during cranial radiation therapy.

Özet

EMPACT sendromu, intrakraniyal malignitesi olan has- taların tedavisinde radyoterapi ve antikonvülzanların beraber kullanılmasına sekonder gelişen eritema mul- tiforme benzeri döküntülerle karakterizedir. Epileptik nöbetler intrakraniyal malignitelerin (primer ve metas- tatik) en sık karşılaşılan komplikasyonu olup, tedavide antikonvülzanlar sıklıkla da fenitoin kullanılmakta- dır. Burada metastatik intrakraniyal malignite tedavisi için radyoterapi ile birlikte fenitoin kullanımı sonrası EMPACT sendromu gelişen iki olgu sunulmaktadır.

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Cite This Article

KOCATÜRK, E., KIZILTAÇ, U., GÜNGÖR, Ş., MEMET, B., YÜKSEL, T. (2014). Should radiotherapy and phenytoin not be given concurrently? EMPACT syndrome. Astım Allerji İmmünoloji, Cilt: 12 - Sayı: 3, 175–179. https://ajindex.com/articles/153269

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