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Journals / Astım Allerji İmmünoloji / 2015 / Cilt: 13 - Sayı: 3

Kronik öksürüklü çocuklarda Chlamydia pneumoniae ve Mycoplasma pneumoniae serolojisi

Seroprevalence of Chlamydia pneumoniae and Seroprevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae in children with chronic cough Mycoplasma pneumoniae in children with chronic cough

Suna ASİLSOY
Erhan BAYRAM
Demet CAN
Pages
124–129
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Th ese microorganisms may cause chronic infl ammation in airway and this condition clinically appear as protracted bronchitis, upper airway cough syndrome and asthma-like disease

📌 3 Key Takeaways

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Objective & Hypothesis:Chronic cough is one of the most common symptoms in children.
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Key Findings & Data:Patients were re-evaluated in 2-4 weeks intervals until cough disappeared.Results: Th e study included 41 children, between 6 and 14 years of age.
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Conclusion & Impact:Th ese microorganisms may cause chronic infl ammation in airway and this condition clinically appear as protracted bronchitis, upper airway cough syndrome and asthma-like disease
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Chronic cough is one of the most common symptoms in children. Post infectious causes following Mycoplasma pneumoniae, Chlamydia pneumoniae and Bordetella pertussis infections play important role in development of chronic cough. Aim of this study was to evaluate M. pneumoniae and C. pneumoniae serology and diagnosis and treatment in children with chronic cough according to American College of Chest Physicians (ACCP) guideline.Materials and Methods: Pulmonary function tests (PFTs) and chest x-rays were obtained in all patients aft er detailed medical history and physical examination. Blood specimens for M. pneumoniae, C. pneumoniae serologies were analyzed by enzyme-linked immunosorbent assay (ELISA). Patients were re-evaluated in 2-4 weeks intervals until cough disappeared.Results: Th e study included 41 children, between 6 and 14 years of age. Th e mean age was 8.00 ± 1.96 year. PFTs and chest x-rays were within normal limits in all children. Th e children with wet cough, comprising 68% of the patients, received 10-day course of Clarithromycin, while those with dry cough were treated with inhaled steroid. M. pneumoniae IgM positivity was found in 17.07% (7/41), C. pneumoniae IgM positivity in 2.85% (1/35), M. pneumoniae IgM and/or IgG positivity in 41.46% (17/41), and C. pneumoniae IgM and/or IgG positivity in 25.7% (9/35) of patients. Seropositive patients with M. pneumoniae and/or C. pneumoniae were diagnosed as protracted bronchitis, upper airway cough syndrome and asthma-like disease according to the guideline. Conclusion: In school-age children with chronic chough, M. pneumoniae and C. pneumoniae seropositivity is in high rates. Th ese microorganisms may cause chronic infl ammation in airway and this condition clinically appear as protracted bronchitis, upper airway cough syndrome and asthma-like disease

Özet

Kronik öksürük çocuklarda sık görülen bir yakınmadır. Postinfeksiyöz nedenler, Mycoplasma pneumoniae, Chlamydia pneumoniae ve Bordetella pertussis infeksiyonlarını takiben daha sık görülen bir yakınmadır. Bu çalışmada kronik öksürüklü çocuklar American College of Chest Physicians (ACCP) tarafından önerilen algoritmaya göre tanı ve tedavi edilerek, M. pneumoniae ve C. pneumoniae serolojisi değerlendirilmiştir.Gereç ve Yöntem: Dört haft adan uzun süren öksürük yakınması ile başvuran hastalardan ayrıntılı öykü ve fizik muayene yapıldıktan sonra solunum fonksiyon testi (SFT) yapıldı ve akciğer grafisi çekildi. Hastalar ACCP algoritmasına göre değerlendirilip tanı ve tedavi uygulanırken M. pneumoniae ve C. pneumoniae serolojisi kan örneklerinden ELISA ile çalışıldı. Hastalar öksürükleri düzelene kadar 4-6 haft a ara ile değerlendirildi.Bulgular: Çalışmaya 6-14 yaş arasında 41 hasta alınmıştır. Hastaların yaş ortalaması 8.00 ± 1.96 yıldı. SFT ve akciğer grafisi hepsinde normal sınırlardaydı. Hastaların %68'inde yaş öksürük vardı. ACCP algoritmasına göre bunlara 10 gün klaritromisin (15 mg/kg/gün), kuru öksürüğü olan hastalara ise inhale steroid (fl utikazon 125 ?g 2 x 1) verildi. Serolojik değerlendirmede; IgM ve/veya IgG pozitifliği M. pneumoniae için %41.46 (17/41), C. pneumoniae için %25.7 (9/35), IgM pozitifl iği M. pneumoniae için %17.07 (7/41)'sinde, C. pneumoniae için %2.85 (1/35) olarak saptandı. Hastalar sıklık sırasına uzamış bronşit, üst hava yolu kaynaklı öksürük sendromu ve astım benzeri hastalık olarak tanı aldı. Conclusion: In school-age children with chronic chough, M. pneumoniae and C. pneumoniae seropositivity is in high rates. Th ese microorganisms may cause chronic infl ammation in airway and this condition clinically appear as protracted bronchitis, upper airway cough syndrome and asthma-like disease

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Cite This Article

ASİLSOY, S., BAYRAM, E., CAN, D. (2015). Kronik öksürüklü çocuklarda Chlamydia pneumoniae ve Mycoplasma pneumoniae serolojisi. Astım Allerji İmmünoloji, Cilt: 13 - Sayı: 3, 124–129. https://ajindex.com/articles/151224

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