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Journals / İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2021 / Cilt: 3 Sayı: 3

Melanocortine System: Appetite and Energy Homeostasis Mechanisms

Melanokortin Sistemi: İştah ve Enerji Homeostazı Etki Mekanizmaları

Ela Altun0000-0003-4129-6955
Sabiha Zeynep Aydenk Köseoğlu(İSTANBUL SABAHATTİN ZAİM ÜNİVERSİTESİ)0000-0001-7936-8462
Pages
212–219
Publication Date
2021-12-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, the working principles of the melanocortin system in appetite and energy balance and its relations with foods are examined.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The appetite and energy balance has been tried to be exposed with researches for many years.
📊
Key Findings & Data:The mechanisms; it is associated with hormones, dopamine, AMPK, exercise, diet, immunoglobulins and lipocalin-2.
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Conclusion & Impact:In this review, the working principles of the melanocortin system in appetite and energy balance and its relations with foods are examined.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Melanokortin · İştah · Enerji dengesi

Abstract

The appetite and energy balance has been tried to be exposed with researches for many years. Melanocortin system has an important role in maintaining this balance in the brain. It provides its functions with different mechanisms. The mechanisms; it is associated with hormones, dopamine, AMPK, exercise, diet, immunoglobulins and lipocalin-2. Malfunctions in the functioning of the melanocortin system cause many metabolic syndromes, especially childhood obesity. It may be important for many diseases to develop treatment methods for these conditions caused by diet-related or genetic variations. In this review, the working principles of the melanocortin system in appetite and energy balance and its relations with foods are examined.

Özet

İştah ve enerji dengesi uzun yıllardır araştırmalarla aydınlatılmaya çalışılmaktadır. Beyindeki melanokortin sistemi bu dengenin korunmasında önemli bir role sahiptir. İşlevlerini vücuttaki farklı mekanizmalarla sağlar. Bu mekanizmalar; hormonlar, dopamin, AMPK, egzersiz, diyet, immünoglobülinler ve lipokalin-2 ile ilişkilidir. Melanokortin sisteminin işleyişindeki bozukluklar başta çocukluk çağı obezitesi olmak üzere birçok metabolik sendroma sebep olur. Diyete bağlı veya genetik varyasyonların sebep olduğu bu durumların tedavi yollarını geliştirmek birçok hastalık için önemli olabilir. Bu derlemede, melanokortin sisteminin iştah ve enerji dengesindeki çalışma prensipleri ve besinlerle olan ilişkileri incelenmiştir.

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Cite This Article

Altun, E., Köseoğlu, S. Z. A. (2021). Melanocortine System: Appetite and Energy Homeostasis Mechanisms. İstanbul Sabahattin Zaim Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 3 Sayı: 3, 212–219. https://doi.org/10.47769/izufbed.1027766

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