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Journals / International Journal of Chemistry and Technology / 2026 / Volume: 7 Issue: 1

Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Nazmiye Bitgen(Erciyes Üniversitesi)0000-0002-6416-9230
Özge Göktepe(ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8205-2132
Münevver Baran(ERCİYES ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ)0000-0003-0369-1022
Eren Kaan İpek(ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8716-5347
Arzu Yay(ERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8532-3543
Pages
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Publication Date
2023-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.

📌 3 Key Takeaways

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Objective & Hypothesis:Nonylphenols are endocrine disrupting toxic compounds and are widely used.
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Key Findings & Data:While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant.
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Conclusion & Impact:High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Nonylphenol · genotoxicity · micronucleus.

Abstract

Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. Groups were classified as control group, the sham administered only group, low dose, medium dose and high dose nonylphenol administered group. After euthanasia, polychromatic erythrocyte/Normochromatic erythrocyte ratio and micronuclear polychromatic erythrocyte count were determined in femur bone marrow cells and analyzed to detect DNA damage. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control. High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.

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Cite This Article

Bitgen, N., Göktepe, Ö., Baran, M., İpek, E. K., Yay, A. (2023). Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology, Volume: 7 Issue: 1. https://doi.org/10.32571/ijct.1186924

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