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Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2025 / Volume: 45 Issue: 4

A Comparative Study on Some Biological Activities of Different Parts of Vincetoxicum hirundinaria

Didem Aksu(Ege Üniversitesi, Merkezi Araştırma Test ve Analiz Laboratuvarı Uygulama ve Araştırma Merkezi)0000-0002-7184-4011
Sevda Güzel Kara(MERSIN UNIVERSITY, FACULTY OF PHARMACY)0000-0002-6642-5824
Pages
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Publication Date
2025-12-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings indicate the plant's potential for cosmetic, dermatological, and pharmaceutical use.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Vincetoxicum hirundinaria Medik. (Apocynaceae) is commonly known as white swallow-wort.
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Key Findings & Data:Total phenolics and flavonoids were detected within the ranges of 8.26–5.34 mg GAE/g and 5.36–2.40 mg QE/g, respectively.
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Conclusion & Impact:These findings indicate the plant's potential for cosmetic, dermatological, and pharmaceutical use.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:DPPH · cytotoxicity · total phenolic content

Abstract

Vincetoxicum hirundinaria Medik. (Apocynaceae) is commonly known as white swallow-wort. Numerous medicinal uses of the species in different countries have been documented in the literature. This research focused on analyzing ethanol-based extracts from various anatomical parts of V. hirundinaria, including flowers, leaves, seeds, and seed pods, to assess their phenolic and flavonoid compound levels, antioxidant activities, and cytotoxic profile. Quantitative assessment of total phenolics and flavonoids was carried out using the Folin–Ciocalteu procedure and the AlCl₃ colorimetric assay, in that order. For antioxidant activity the DPPH radical scavenging assay was used. Total phenolics and flavonoids were detected within the ranges of 8.26–5.34 mg GAE/g and 5.36–2.40 mg QE/g, respectively. The flower extract showed the greatest antioxidant performance, with 75.2% activity and an ascorbic acid equivalent of 13.7 mM per gram of sample. Furthermore, cytotoxicity was tested on HaCaT cell lines using the MTT assay. In all experiments involving plant extracts and at all tested concentrations (0.25-1 mg/mL) no toxic effects were observed on HaCaT cells. These findings indicate the plant's potential for cosmetic, dermatological, and pharmaceutical use. This is the first comparative study performed on ethanol extracts of different parts of V. hirundinaria.

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Cite This Article

Aksu, D., Kara, S. G. (2025). A Comparative Study on Some Biological Activities of Different Parts of Vincetoxicum hirundinaria. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Volume: 45 Issue: 4. https://doi.org/10.52794/hujpharm.1699849

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