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Journals / Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi / 2026 / Volume: 46 Issue: 2

Metabolic Effects of Polyphenol-rich Aronia melanocarpa on Obesity and Lipid Metabolism

Zeynep Nil Doğruer Ünal(Mersin Üniversitesi Eczacılık Fakültesi Biyokimya AD)0000-0002-4083-0944
Tülay Özkaya(MERSIN UNIVERSITY)0000-0003-4553-2767
Serap Yalın(MERSIN UNIVERSITY)0000-0002-1286-2172
Pages
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Publication Date
2026-06-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Overall, Aronia melanocarpa appears to be a promising natural agent for the management of obesity and dyslipidaemia, however, further well-designed clinical studies using standardized preparations are required to confirm its therapeutic potential.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Obesity and obesity-related dyslipidaemia are major contributors to global cardiometabolic risk.
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Key Findings & Data:Polyphenol-rich functional foods have gained attention as supportive strategies for the regulation of lipid metabolism and adipose tissue function.
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Conclusion & Impact:Overall, Aronia melanocarpa appears to be a promising natural agent for the management of obesity and dyslipidaemia, however, further well-designed clinical studies using standardized preparations are required to confirm its therapeutic potential.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Aronia melanocarpa · obesity · lipid metabolism

Abstract

Obesity and obesity-related dyslipidaemia are major contributors to global cardiometabolic risk. Polyphenol-rich functional foods have gained attention as supportive strategies for the regulation of lipid metabolism and adipose tissue function. Among these, Aronia melanocarpa (black chokeberry) is a rich source of anthocyanins and other bioactive polyphenols with potent antioxidant and metabolic properties. This review evaluates current experimental and clinical evidence on the effects of Aronia melanocarpa on obesity and lipid metabolism. Available data indicate that chokeberry polyphenols may improve lipid homeostasis by modulating adipogenesis, regulating key metabolic pathways, reducing oxidative stress and inflammation, and influencing gut microbiota. However, clinical findings remain heterogeneous due to variations in study design, dosage, and phytochemical composition, as well as the limited bioavailability of anthocyanins. Overall, Aronia melanocarpa appears to be a promising natural agent for the management of obesity and dyslipidaemia, however, further well-designed clinical studies using standardized preparations are required to confirm its therapeutic potential.

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Cite This Article

Ünal, Z. N. D., Özkaya, T., Yalın, S. (2026). Metabolic Effects of Polyphenol-rich Aronia melanocarpa on Obesity and Lipid Metabolism. Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, Volume: 46 Issue: 2. https://doi.org/10.52794/hujpharm.1910616

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References (56)

  1. Busebee B, Ghusn W, Cifuentes L, Acosta A. Obesity: a review of pathophysiology and classification. Mayo Clin Proc. 2023;98(12):1842-57. https://doi.org/10.1016/j.mayocp. 2023.05.026
  2. Hildebrandt X, Ibrahim M, Peltzer N. Cell death and inflammation during obesity: know my methods, WAT(son). Cell Death Differ. 2023;30(2):279-92. https://doi.org/10.1038/s41418-022-01062-4
  3. Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017;127(1):1-4. https://doi.org/10.1172/JCI92035
  4. GBD 2021 Risk Factors Collaborators. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403:2162-2203. https://doi.org/10.1016/S0140-6736(24)00933-4
  5. Barrera-Esparza M, Carreón-Torres E, Jiménez-Osorio AS, Angel-García J, Jiménez-Garza O, Flores-Chávez OR, et al. Complex network interactions between bioactive compounds and adipose tissue vis-à-vis insulin resistance. Front Endocrinol (Lausanne). 2025;16:1578552. https://doi.org/10.3389/fendo.2025.1578552
  6. Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375-91. https://doi.org/10.1152/ajpcell.00379.2020
  7. Naz R, Saqib F, Awadallah S, Wahid M, Latif MF, Iqbal I, et al. Food polyphenols and type II diabetes mellitus: pharmacology and mechanisms. Molecules. 2023;28(10):3996. https://doi.org/10.3390/molecules28103996
  8. Wan S, Luo J, Zhu Y, An P, Luo Y, Xing Q, et al. Effect of antioxidant polyphenol supplementation on cardiometabolic risk factors: a systematic review and meta-analysis. Nutrients. 2024;16(23):4206. https://doi.org/10.3390/nu16234206
  9. King ES, Bolling BW. Composition, polyphenol bioavailability and health benefits of aronia berry: a review. J Food Bioact. 2020;11:13-30. https://doi.org/10.31665/JFB.2020.11235
  10. Ren Y, Frank T, Meyer G, Lei J, Grebenc JR, Slaughter R, et al. Potential benefits of black chokeberry (Aronia melanocarpa) fruits and their constituents in improving human health. Molecules. 2022;27(22):7823. https://doi.org/10.3390/molecules27227823
  11. Xu J, Li F, Zheng M, Sheng L, Shi D, Song K. Functional potential and sustainable applications of Aronia melanocarpa in the food industry: a comprehensive review. Plants. 2024;13(24):355. https://doi.org/10.3390/plants13243557
  12. Go MY, Kim J, Jeon CY, Shin DW. Functional activities and mechanisms of Aronia melanocarpa in human health. Curr Issues Mol Biol. 2024;46(8):8071-87. https://doi.org/10.3390/cimb46080477
  13. Lackner S, Mahnert A, Moissl-Eichinger C, Madl T, Habisch H, Meier-Allard N, et al. Interindividual differences in aronia juice tolerability linked to gut microbiome and metabolome changes: secondary analysis of a randomized placebo-controlled parallel intervention trial. Microbiome. 2024;12(1):49. https://doi.org/10.1186/s40168-024-01774-4
  14. Oumeddour DZ, Al-Dalali S, Zhao L, Wang C. Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: a comprehensive review. Biochem Biophys Res Commun. 2024;729:150344. https://doi.org/10.1016/j.bbrc.2024.150344
  15. Piras A, Porcedda S, Smeriglio A, Trombetta D, Nieddu M, Piras F, et al. Chemical composition, nutritional and biological properties of extracts obtained with different techniques from Aronia melanocarpa berries. Molecules. 2024;29(11):2577. https://doi.org/10.3390/molecules29112577
  16. Chamberlin ML, Peach JT, Wilson SMG, Miller ZT, Bothner B, Walk ST, et al. Polyphenol-rich Aronia melanocarpa fruit beneficially impacts cholesterol, glucose and serum and gut metabolites: a randomized clinical trial. Foods. 2024;13(17):2768. https://doi.org/10.3390/foods13172768
  17. Ye X, Chen W, Huang XF, Yan FJ, Deng SG, Zheng XD, et al. Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin-resistant hepatocyte and diabetic mouse. Nutr Diabetes. 2024;14(1):7. https://doi.org/10.1038/s41387-024-00265-7
  18. Zhou Y, Saarniit K, Jafari MS, Rosenvald S, Laaksonen O, Tian Y, et al. Storage stability of berry mueslis with special focus on phenolic compounds. LWT. 2025;228:118119. https://doi.org/10.1016/j.lwt.2025.118119
  19. Özyürek M, Çetin Sİ, Önem AN. Microwave-assisted extraction of Turkish Aronia melanocarpa fruit: modeling, optimization and characterization of commercial products. J Chem Metrol. 2025;19(2):185-198. https://doi.org/10.25135/jcm.120.2509.3647
  20. Köpsel M, Ozkan G, Esatbeyoglu T. Metabolic fate of chokeberry (Aronia melanocarpa) phenolics in different food matrices. Curr Res Food Sci. 2025;10:100967. https://doi.org/10.1016/j.crfs.2024.100967
  21. Yaşa Kafkas NE, Çelik H, editors. Edible berries: new insights. London: IntechOpen; 2023. https://doi.org/10.5772/intechopen.105241
  22. Jurendić T, Ščetar M. Aronia melanocarpa products and by-products for health and nutrition: a review. Antioxidants. 2021;10(7):1052. https://doi.org/10.3390/antiox10071052
  23. Mrázová J, Kopčeková J, Habánová M, Gažarová M, Lenártová P. The effect of regular chokeberry juice consumption on anthropometric and lipid parameters in women with overweight or obesity. Rocz Panstw Zakl Hig. 2024;75(2):161-7. https://doi.org/10.32394/rpzh/189876
  24. Sanlier N, Cinar EN. Aronia berry (Aronia melanocarpa L.) as a bioactive treasure: insights into its health-promoting effects. J Funct Foods. 2025;135:107116. https://doi.org/10.1016/j.jff.2025.107116
  25. Sivamaruthi BS, Kesika P, Chaiyasut C. The influence of supplementation of anthocyanins on obesity-associated comorbidities: a concise review. Foods. 2020;9(6):687. https://doi.org/10.3390/foods9060687
  26. Zhu Y, Cai PJ, Dai HC, Xiao YH, Jia CL, Sun AD. Black chokeberry (Aronia melanocarpa L.) polyphenols attenuate obesity-induced colonic inflammation by regulating gut microbiota and the TLR4/NF-κB signaling pathway in high fat diet-fed rats. Food Funct. 2023;14(22):10014-30. https://doi.org/10.1039/D3FO02177G
  27. Kulling S, Rawel H. Chokeberry (Aronia melanocarpa): a review on the characteristic components and potential health effects. Planta Med. 2008;74(13):1625-34. https://doi.org/10.1055/s-0028-1088306
  28. Bayhan N, Yücesan B. The impact of sucrose and 6-benzylaminopurine on shoot propagation and vitrification in Aronia melanocarpa. Plant Cell Tissue Organ Cult. 2024;156(2):55. https://doi.org/10.1007/s11240-023-02652-x
  29. Zhu Y, Wei YL, Karras I, Cai PJ, Xiao YH, Jia CL, et al. Modulation of the gut microbiota and lipidomic profiles by black chokeberry (Aronia melanocarpa L.) polyphenols via the glycerophospholipid metabolism signaling pathway. Front Nutr. 2022;9:913729. https://doi.org/10.3389/fnut.2022.913729
  30. Lee HY, Suh KS, Kim YI, Jang BK, Kim BH, Yim SV. Bioactive fraction of Aronia melanocarpa fruit inhibits adipogenic differentiation of cultured 3T3-L1 cells. Appl Sci. 2021;11(19):9224. https://doi.org/10.3390/app11199224
  31. Kim NY, Thomas SS, Hwang DI, Lee JH, Kim KA, Cha YS. Anti-obesity effects of Morus alba L. and Aronia melanocarpa in a high-fat diet-induced obese C57BL/6J mouse model. Foods. 2021;10(8):1914. https://doi.org/ 10.3390/foods10081914
  32. Kim NH, Jegal J, Kim YN, Heo JD, Rho JR, Yang MH, et al. Chokeberry extract and its active polyphenols suppress adipogenesis in 3T3-L1 adipocytes and modulate fat accumulation and insulin resistance in diet-induced obese mice. Nutrients. 2018;10(11):1734. https://doi.org/10.3390/nu10111734
  33. Xu P, He Y, Wang J, Sheng Y, Wang J. Blueberry anthocyanins ameliorate hepatic dysfunction in high-fat diet-fed mice: association with altered gut microbiota and bile acid metabolism. Foods. 2025;14(17):3121. https://doi.org/10.3390/foods14173121
  34. Alam MA, Islam P, Subhan N, Rahman MM, Khan F, Burrows GE, et al. Potential health benefits of anthocyanins in oxidative stress-related disorders. Phytochem Rev. 2021;20(4):705-49. https://doi.org/10.1007/s11101-021-09757-1
  35. Deepa P, Hong M, Sowndhararajan K, Kim S. A review of the role of an anthocyanin, cyanidin-3-O-β-glucoside in obesity-related complications. Plants. 2023;12(22):3889. https://doi.org/10.3390/plants12223889
  36. Zhu Y, Zhang JY, Wei YL, Hao JY, Lei YQ, Sun AD. The polyphenol-rich extract from chokeberry (Aronia melanocarpa L.) modulates gut microbiota and improves lipid metabolism in diet-induced obese rats. Nutr Metab (Lond). 2020;17:35. https://doi.org/10.1186/s12986-020-00473-9
  37. Kapoor P, Tiwari A, Sharma S, Tiwari V, Sheoran B, Ali U, et al. Effect of anthocyanins on gut health markers, Firmicutes-Bacteroidetes ratio and short-chain fatty acids: a systematic review via meta-analysis. Sci Rep. 2023;13(1):1729. https://doi.org/10.1038/s41598-023-28764-0
  38. Kasprzak-Drozd K, Oniszczuk T, Soja J, Gancarz M, Wojtunik-Kulesza K, Markut-Miotła E, et al. The efficacy of black chokeberry fruits against cardiovascular diseases. Int J Mol Sci. 2021;22(12):6541. https://doi.org/10.3390/ijms22126541
  39. Wang Y, Do T, Marshall LJ, Boesch C. Effect of two-week red beetroot juice consumption on modulation of gut microbiota in healthy human volunteers: a pilot study. Food Chem. 2023;406:134989. https://doi.org/10.1016/j.foodchem.2022.134989
  40. Van Buiten CB, Seitz VA, Metcalf JL, Raskin I. Dietary polyphenols support Akkermansia muciniphila growth via mediation of the gastrointestinal redox environment. Antioxidants. 2024;13(3):304. https://doi.org/10.3390/antiox13030304
  41. Wilson SMG, Peach JT, Fausset H, Miller ZT, Walk ST, Yeoman CJ, et al. Metabolic impact of polyphenol-rich aronia fruit juice mediated by inflammation status of gut microbiome donors in a humanized mouse model. Front Nutr. 2023;10:1244692. https://doi.org/10.3389/fnut.2023.1244692
  42. Du L, Ding X, Zhang W, Huang L, Lü H, Jian T, et al. Anthocyanins from blueberry and blackberry ameliorate metabolic syndrome via Prevotella histicola and acetic acid. npj Sci Food. 2025;9(1):158. https://doi.org/10.1038/s41538-025-00526-4
  43. Pan J, Liang J, Xue Z, Meng X, Jia L. Effect of dietary anthocyanins on risk factors related to metabolic syndrome: a systematic review and meta-analysis. PLoS One. 2025;20(2):e0315504. https://doi.org/10.1371/journal.pone.0315504
  44. Xu J, Li F, Zheng M, Sheng L, Shi D, Song K. A comprehensive review of the functional potential and sustainable applications of Aronia melanocarpa in the food industry. Plants. 2024;13(24):3557. https://doi.org/10.3390/plants13243557
  45. Sikora J, Broncel M, Markowicz M, Chałubiński M, Wojdan K, Mikiciuk-Olasik E. Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting and fibrinolysis in patients with metabolic syndrome. Eur J Nutr. 2012;51(5):549-56. https://doi.org/10.1007/s00394-011-0238-8
  46. Mikami N, Hosotani Y, Saso T, Ohta T, Miyashita K, Hosokawa M. Black chokeberry (Aronia melanocarpa) juice residue and its ethanol extract decrease serum lipid levels in high-fat diet-fed mice. Int J Funct Nutr. 2020;1(2):10. https://doi.org/10.3892/ijfn.2020.10
  47. Kuru YA, Kılınç GE. Aronia melanocarpa as a multifunctional superberry: from antioxidant potential to therapeutic and nanotechnological applications. Curr Nutr Rep. 2026;15(1):9. https://doi.org/10.1007/s13668-026-00736-6
  48. Ma J, Zheng Y, Tang W, Yan W, Nie H, Fang J, et al. Dietary polyphenols in lipid metabolism: a role of gut microbiome. Anim Nutr. 2020;6(4):404-9. https://doi.org/10.1016/j.aninu.2020.08.002
  49. Lim SM, Lee HS, Jung JI, Kim SM, Kim NY, Seo TS, et al. Cyanidin-3-O-galactoside-enriched Aronia melanocarpa extract attenuates weight gain and adipogenic pathways in high-fat diet-induced obese mice. Nutrients. 2019;11(5):1190. https://doi.org/10.3390/nu11051190
  50. Park CH, Kim JH, Lee EB, Hur W, Kwon OJ, Park HJ, et al. Aronia melanocarpa extract ameliorates hepatic lipid metabolism through PPARγ2 downregulation. PLoS One. 2017;12(1):e0169685. https://doi.org/10.1371/journal.pone.0169685
  51. Takahashi A, Shimizu H, Okazaki Y, Sakaguchi H, Taira T, Suzuki T, et al. Anthocyanin-rich phytochemicals from Aronia fruits inhibit visceral fat accumulation in high-fat diet-induced obese rats. J Oleo Sci. 2015;64(12):1243-50. https://doi.org/10.5650/jos.ess15181
  52. Buda V, Andor M, Diana A, Ardelean F, Pavel IZ, Dehelean C, et al. Cardioprotective effects of cultivated black chokeberries (Aronia spp.): traditional uses, phytochemistry and therapeutic effects. In: Bioactive compounds in nutraceutical and functional food for good human health. London: IntechOpen; 2021. https://doi.org/10.5772/intechopen.92238
  53. Daskalova E, Delchev S, Vladimirova-Kitova L, Kitov S, Denev P. Black chokeberry (Aronia melanocarpa) functional beverages increase HDL-cholesterol levels in aging rats. Foods. 2021;10(7):1641. https://doi.org/10.3390/foods10071641
  54. Zapolska-Downar D, Bryk D, Małecki M, Hajdukiewicz K, Sitkiewicz D. Aronia melanocarpa fruit extract exhibits anti-inflammatory activity in human aortic endothelial cells. Eur J Nutr. 2012;51(5):563-72. https://doi.org/10.1007/s00394-011-0240-1
  55. Daskalova E, Delchev S, Peeva Y, Vladimirova-Kitova L, Kratchanova M, Kratchanov C, et al. Antiatherogenic and cardioprotective effects of black chokeberry juice in aging rats. Evid Based Complement Alternat Med. 2015;2015:717439. https://doi.org/10.1155/2015/717439
  56. Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J. Aronia melanocarpa extract reduces blood pressure, endothelin, lipid and oxidative stress marker levels in patients with metabolic syndrome. Med Sci Monit. 2010;16(1):CR28-34. PMID: 20037491.