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Journals / The Turkish Journal of Ear Nose and Throat / 2026 / Volume: 34 Issue: 1

Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Saber Chebouki(Mersin University, Faculty of Pharmacy, Department of Biochemistry)0000-0003-0768-8728
Zeynep Nil Ünal(Mersin University, Faculty of Pharmacy, Department of Biochemistry)0000-0002-4083-0944
Kemal Koray Bal(Mersin University, Faculty of Medicine, Department of Otorhinolaryngology)0000-0002-2000-0601
Harun Gür(Mersin University, Faculty of Medicine, Department of Otorhinolaryngology)0000-0001-6165-2350
Onur İsmi(Mersin University, Faculty of Medicine, Department of Otorhinolaryngology)0000-0001-5061-8907
Murat Ünal(Mersin University, Faculty of Medicine, Department of Otorhinolaryngology)0000-0002-5524-9175
Pages
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Publication Date
2024-03-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990.
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Key Findings & Data:Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study.
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Conclusion & Impact:Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Vitamin D · genes · neoplasms

Abstract

Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor (VDR) is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer. Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study. Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups. Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker.

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Cite This Article

Chebouki, S., Ünal, Z. N., Bal, K. K., Gür, H., İsmi, O., Ünal, M. (2024). Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat, Volume: 34 Issue: 1. https://doi.org/10.26650/Tr-ENT.2024.1402917

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