Journals / Experimental and Applied Medical Science / 2026 / Cilt: 7 Sayı: 2

Botulinum Toxin Treatment for Refractory Sialorrhea in a Geriatric Patient with Parkinson’s and Alzheimer’s Disease: A Case Report

Parkinson ve Alzheimer Hastalığı Olan Geriatrik Bir Hastada Refrakter Sialore Tedavisinde Botulinum Toksin Uygulaması: Olgu Sunumu

Ayşe Fulya Özkanlı(Gaziantep Islam Science and Technology University Faculty of Medicine,Department of Public Health,Gaziantep,Türkiye)0000-0002-0743-8158
Saffet Ulutaş(SU Private Practice in Plastic,Reconstructive and Aesthetic Surgery,Gaziantep ,Türkiye)0000-0002-8214-4002
İbrahim Halil Türkbeyler(Gaziantep Islam Science and Tecnology University Faculty of Medicine, Department of Internal Medicine Division of Geriatric Medicine,Gaziantep,Türkiye)0000-0002-5489-1692
Pages
167–172
Publication Date
2026-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this case report, the efficacy and safety of botulinum toxin administration are presented in a 78-year-old male patient with diagnoses of Parkinson's and Alzheimer's disease who presented with complaints of profuse salivation from the mouth and nose.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Sialorrhea, otherwise known as hypersalivation, is a symptom frequently observed in neurodegenerative diseases such as Parkinson's disease and dementia.
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Key Findings & Data:This condition can have a significant impact on the patient's social life and quality of life.
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Conclusion & Impact:In this case report, the efficacy and safety of botulinum toxin administration are presented in a 78-year-old male patient with diagnoses of Parkinson's and Alzheimer's disease who presented with complaints of profuse salivation from the mouth and nose.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Sialore · Parkinson hastalığı · Alzheimer hastalığı

Abstract

Sialorrhea, otherwise known as hypersalivation, is a symptom frequently observed in neurodegenerative diseases such as Parkinson's disease and dementia. This condition can have a significant impact on the patient's social life and quality of life. Pharmacological treatments frequently prove to be either ineffective or intolerable for elderly patients. In this case report, the efficacy and safety of botulinum toxin administration are presented in a 78-year-old male patient with diagnoses of Parkinson's and Alzheimer's disease who presented with complaints of profuse salivation from the mouth and nose.

Özet

Sialore (hipersalivasyon), özellikle Parkinson hastalığı ve demans gibi nörodejeneratif hastalıklarda sık görülen, hastanın sosyal yaşamını ve yaşam kalitesini ciddi biçimde bozan bir semptomdur. Farmakolojik tedaviler çoğu zaman yetersiz kalmakta veya yaşlı hastalarda tolere edilememektedir. Bu olgu sunumunda, Parkinson ve Alzheimer tanıları bulunan, ağız ve burundan yoğun tükürük akması şikâyeti ile başvuran 78 yaşındaki erkek hastada botulinum toksin uygulamasının etkinliği ve güvenilirliği sunulmuştur.

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Cite This Article

Özkanlı, A. F., Ulutaş, S., Türkbeyler, İ. H. (2026). Botulinum Toxin Treatment for Refractory Sialorrhea in a Geriatric Patient with Parkinson’s and Alzheimer’s Disease: A Case Report. Experimental and Applied Medical Science, Cilt: 7 Sayı: 2, 167–172. https://doi.org/10.46871/eams.1934747

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References (13)

  1. Hyson HC, Johnson AM, Jog MS. Drooling in Parkinson’s disease: a review. Mov Disord. 2002;17(6):131-136.
  2. Srivanitchapoom P, Pandey S, Hallett M. Drooling in Parkinson’s disease: a review. Parkinsonism Relat Disord. 2014;20(11):1109-1118.
  3. Easterling CS, Robbins E. Dementia and dysphagia. Geriatr Nurs. 2008;29(4):275-285.
  4. Scully C, Limeres J, Gleeson M. Drooling. J Oral Pathol Med. 2009;38(4):321-327.
  5. Arbouw ME, et al. Botulinum toxin for sialorrhea in Parkinson disease. Neurology. 2010;74(15):1203-1207.
  6. Jongerius PH, et al. Botulinum toxin effect on salivary flow rate in children with cerebral palsy. Neurology. 2004;63(8):1371-1375.
  7. Kalf JG, et al. Dysphagia in Parkinson’s disease. Lancet Neurol. 2012;11(7):628-638.
  8. Volicer L, et al. Eating difficulties in patients with probable dementia of the Alzheimer type. J Geriatr Psychiatry Neurol. 1989;2(4):188-195.
  9. Tune LE. Anticholinergic effects of medication in elderly patients. J Clin Psychiatry. 2001;62(Suppl 21):11-14.
  10. Ellies M, et al. Reduction of salivary flow with botulinum toxin. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(5):543-548.
  11. Ondo WG, et al. Botulinum toxin A for sialorrhea in Parkinson disease. Neurology. 2004;62(1):37-40.
  12. Tiigimäe-Saar J, et al. Botulinum toxin treatment of sialorrhea. Clin Neurol Neurosurg. 2012;114(4):395-399.
  13. Lakraj AA, et al. Botulinum toxin A for treatment of sialorrhea. Clin Interv Aging. 2013;8:721-730.