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Journals / Astım Allerji İmmünoloji / 2016 / Cilt: 14 - Sayı: 1

A Case of Cyanocobalamin Allergy with Tolerance to Hydroxycobalamin

Siyanokobalamin Allerjisi Olan Bir Olguda Hidroksikobalamine Tolerans

Özlem YILMAZ
Funda Erkasar ÇITAK
Pages
52–54
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this case report, it is emphasized that an allergic evaluation including provocation tests should also be done in patients with suspected allergy to vitamin B12 in addition to skin prick tests and intradermal (ID) tests.

📌 3 Key Takeaways

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Objective & Hypothesis:Immediate type allergic reactions to vitamin B12 is a rarely encountered condition.
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Key Findings & Data:Commercial preparations of vitamin B12 (cyanocobalamin and hydroxycobalamin) can lead to Type 1 hypersensitivity reactions.
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Conclusion & Impact:In this case report, it is emphasized that an allergic evaluation including provocation tests should also be done in patients with suspected allergy to vitamin B12 in addition to skin prick tests and intradermal (ID) tests.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Immediate type allergic reactions to vitamin B12 is a rarely encountered condition. Commercial preparations of vitamin B12 (cyanocobalamin and hydroxycobalamin) can lead to Type 1 hypersensitivity reactions. Allergic reactions to vitamin B12 may consist of urticaria, angioedema and anaphylaxis. Some patients develop an allergic reaction to a derivative of vitamin B12 and can tolerate the other commercial form. Allergic reactions may sometimes occur against both compounds of vitamin B12. We presented a case of cyanocobalamin allergy who could tolerate hydroxycobalamin. Cyanocobalamin allergy and hydroxycobalamin tolerance was demonstrated by provocation tests. In this case report, it is emphasized that an allergic evaluation including provocation tests should also be done in patients with suspected allergy to vitamin B12 in addition to skin prick tests and intradermal (ID) tests.

Özet

B12 vitaminine bağlı erken tip allerjik reaksiyonlar nadir olarak görülür. B12 vitamininin ticari preparatları (siyanokobalamin ve hidroksikobalamin) Tip 1 aşırı duyarlılık reaksiyonlarına neden olabilmektedir. B12 vitamini ile ürtiker, anjiyoödem ve anafilaksi bildirilmiştir. Bazen hastalar B12 vitamininin bir türevine karşı allerjik reaksiyon geliştirir ve diğer formunu tolere edebilir. Bazı olgularda allerjik reaksiyonlar B12 vitamininin her iki ticari türevine karşı gelişebilir. Bu olgu raporunda siyanokobalamin allerjisi olan fakat hidroksikobalamini tolere edebilen bir olgu sunulmuştur. Olgunun siyanokobalamin allerjisi ve hidroksikobalamin toleransı provokasyon testleriyle gösterilmiştir. Bu olgu sunumuyla B12 vitamini allerjisi düşünülen olgularda prik ve intradermal (İD) testler yanında provokasyon testlerini de içeren bir allerjik değerlendirme yapılması gerektiği vurgulamıştır.

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Cite This Article

YILMAZ, Ö., ÇITAK, F. E. (2016). A Case of Cyanocobalamin Allergy with Tolerance to Hydroxycobalamin. Astım Allerji İmmünoloji, Cilt: 14 - Sayı: 1, 52–54. https://ajindex.com/articles/148287

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