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Journals / Eurasian Journal of Critical Care / 2023 / Cilt: 5 Sayı: 3

EXAMINATION OF NEUTROPHIL/LYMPHOCYTE (NLR), MONOCYTE/LYMPHOCYTE (MLR), AND PLATELET/LYMPHOCYTE (PLR) RATIOS BETWEEN ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA

Taylan Yavuz Bulut(NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, SÜREKLİ EĞİTİM UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-6709-6647
Ahmet Şair(AYDIN ADNAN MENDERES ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-1384-6518
Pages
102–106
Publication Date
2023-12-27
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, there is a need for additional studies on peripheral blood cells to identify the potential prodromal biomarkers of AD.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: The present study aims to investigate whether proinflammatory marker ratios in whole blood differ in these two dementia diseases.
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Key Findings & Data:The admission blood results of patients who presented between January 2018 and September 2020 will be included, and the patients’ hemogram results will be scanned retrospectively.
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Conclusion & Impact:Furthermore, there is a need for additional studies on peripheral blood cells to identify the potential prodromal biomarkers of AD.
🔬Design:Araştırma Makalesi
📍Scope:2018 Verileri
⚙️Variables:Alzheimer · NLR · proinflammatory markers

Abstract

Background: The present study aims to investigate whether proinflammatory marker ratios in whole blood differ in these two dementia diseases. Materials and Methods: This study will involve Alzheimer's disease (AD) and vascular dementia (VaD) patients who were treated as outpatients in the outpatient clinic and inpatients in the ward of the Neurology Department of Adnan Menderes University Hospital. The patients’ diagnoses will be scanned in the hospital information system. The admission blood results of patients who presented between January 2018 and September 2020 will be included, and the patients’ hemogram results will be scanned retrospectively. Neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratios in the hemogram results will be calculated and recorded. Results: In the AD-VaD comparison of the patients participating in the study, a significant difference was identified between the variability of platelet/lymphocyte (PLR) and NLRs (NLR) (p<0.001). Moreover, a significant difference was found between the mean ages of patients with vascular dementia and those with Alzheimer's dementia (p<0.0001). Conclusion: While proinflammatory markers obtained secondary to inflammation are significant in AD since it is a chronic and progressive process, the use of these markers is limited due to the gradual course after an acute event in vascular dementia. Furthermore, there is a need for additional studies on peripheral blood cells to identify the potential prodromal biomarkers of AD.

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Cite This Article

Bulut, T. Y., Şair, A. (2023). EXAMINATION OF NEUTROPHIL/LYMPHOCYTE (NLR), MONOCYTE/LYMPHOCYTE (MLR), AND PLATELET/LYMPHOCYTE (PLR) RATIOS BETWEEN ALZHEIMER'S DISEASE AND VASCULAR DEMENTIA. Eurasian Journal of Critical Care, Cilt: 5 Sayı: 3, 102–106. https://doi.org/10.55994/ejcc.1394602

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