Journals / Astım Allerji İmmünoloji / 2017 / Cilt: 15 - Sayı: 2

Kronik Spontan Ürtikerli Çocuklarda Ortalama Trombosit Hacmi

Mean Platelet Volume in Children with Chronic Spontaneous Urticaria

Pages
87–92
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

However, the mean platelet volume does not appear to be associated with the erythrocyte sedimentation rate and atopy

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: It has been suggested that mean platelet volume can be used as a marker of inflammation in some inflammatory diseases.
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Key Findings & Data:Materials and Methods: Fifty-four children with chronic spontaneous urticaria (26 boys and 28 girls, mean age 13.70±3.66 years) were included in this retrospective study.
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Conclusion & Impact:However, the mean platelet volume does not appear to be associated with the erythrocyte sedimentation rate and atopy
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: It has been suggested that mean platelet volume can be used as a marker of inflammation in some inflammatory diseases. This marker has not been investigated adequately in children with allergic disease. The aim of this study was to evaluate mean platelet volume in children with chronic spontaneous urticaria. Materials and Methods: Fifty-four children with chronic spontaneous urticaria (26 boys and 28 girls, mean age 13.70±3.66 years) were included in this retrospective study. The demographic characteristics, complete blood count, serum total IgE, erythrocyte sedimentation rate, and skin prick tests results of the patients were recorded. Sixty healthy children were included as the control group. Only complete blood count results of the control group were recorded. Platelet count, mean platelet volume, platelet distribution width, leukocyte count, and hemoglobin values were compared between the two groups. Correlations between mean platelet volume with age, disease duration, atopy, serum total IgE, and erythrocyte sedimentation rate were analyzed in the patient group. Results: There was no statistically significant difference in terms of age and sex between the two groups (p=0.09, p=0.60, respectively). Mean platelet volume and platelet count in the patient group were significantly higher than those in the control group (p=0.005, p=0.01, respectively). Platelet distribution widths in the patient group were significantly lower than those in the control group (p<0.001). There was no significant difference in leukocyte count and hemoglobin values between the two groups (p>0.05). Mean platelet volumes in the patient group were not correlated with age, disease duration, atopy, serum total IgE, and erythrocyte sedimentation rate. Conclusion: Mean platelet volumes and platelet counts are increased in children with chronic spontaneous urticaria. However, the mean platelet volume does not appear to be associated with the erythrocyte sedimentation rate and atopy

Özet

Giriş: Ortalama trombosit hacminin, bazı inflamatuvar hastalıklarda inflamasyonun bir belirteci olarak kullanılabileceği ileri sürülmektedir. Bu belirteç allerjik hastalığa sahip çocuklarda yeteri kadar çalışılmamıştır. Çalışmanın amacı, kronik spontan ürtikerli çocuklarda ortalama trombosit hacminin değerlendirilmesidir.Gereç ve Yöntem: Bu retrospektif çalışmaya kronik spontan ürtikerli 54 çocuk dahil edildi (26 erkek, 8 kız, ortalama yaş 13.70±3.66 yıl). Demografik özellikler, tam kan sayımı, total serum IgE, eritrosit sedimantasyon hızı ve deri prik testi sonuçları kaydedildi. Kontrol grubu olarak 60 sağlıklı çocuk dahil edildi. Kontrol grubun sadece tam kan sayımı sonuçları kaydedildi. Her iki grubun trombosit sayısı, ortalama trombosit sayısı, trombosit dağılım genişliği, lökosit sayısı ve hemoglobin değerleri karşılaştırıldı. Hasta grubunda ortalama trombosit hacmi ile yaş, hastalık süresi, deri testi pozitifliği, total serum IgE ve eritrosit sedimantasyon hızı karşılaştırıldı.Bulgular: İki grup arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı farklılık yoktu (sırasıyla, p=0.09, p=0.60). Hasta grubun ortalama trombosit hacmi ve trombosit sayısı kontrol grubunkine göre anlamlı olarak daha yüksekti (sırasıyla, p=0.005, p=0.01). Hasta grubun trombosit dağılım genişliği kontrol grubunkine göre anlamlı olarak daha düşüktü (p 0.05). Hasta grubun ortalama trombosit hacmi ile yaş, hastalık süresi, deri testi pozitifliği, total serum IgE ve eritrosit sedimantasyon arasında ilişki bulunmadı. Conclusion: Mean platelet volumes and platelet counts are increased in children with chronic spontaneous urticaria. However, the mean platelet volume does not appear to be associated with the erythrocyte sedimentation rate and atopy.Sonuç: Kronik spontan ürtikerli çocuklarda ortalama trombosit hacmi ve trombosit sayısı artmaktadır. Bununla beraber ortalama trombosit hacmi eritrosit sedimentasyon ve atopiyi gösteren testlerle ilişkili görülmemektedir.

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Cite This Article

KUTLUĞ, Ş., SÖĞÜT, A., ÇELİKSOY, M. H., PAKSU, M. Ş., GÜNER, Ş. N., MURAT, N., ÖZTÜRK, F., SANCAK, R. (2017). Kronik Spontan Ürtikerli Çocuklarda Ortalama Trombosit Hacmi. Astım Allerji İmmünoloji, Cilt: 15 - Sayı: 2, 87–92. https://ajindex.com/articles/147395

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References (16)

  1. Greaves MW. Chronic urticaria in childhood. Allergy 2000;55:309-20
  2. Maurer M. Unmet clinical needs in chronic spontaneous urticaria. A GA²LEN task force report. Allergy 2011;66:317-30
  3. Tsakok T, Du Toit G, Flohr C. Pediatric urticaria. Immunol Allergy Clin North Am 2014; 34:117-39
  4. Zuberbier T. Chronic urticaria. Curr Allergy Asthma Rep 2012;12:267-72
  5. Baiardini I, Braido F, Bindslev-Jensen C, Bousquet PJ, Brzoza Z, Canonica GW, et al. Recommendations for assessing patientreported outcomes and health-related quality of life in clinical trials on allergy: A GA²LEN taskforce position paper. Allergy 2010; 65: 290-5
  6. Thompson CB, Jakubowski JA. The pathophysiology and clinical relevance of platelet heterogeneity. Blood 1988;72:1-8
  7. Page C, Pitchford S. Platelets and allergic inflammation. Clin Exp Allergy 2014; 44:901-13
  8. Brindley LL, Sweet JM, Goetzl EJ. Stimulation of histamine release from human basophils by human platelet factor. J Clin Invest 1983;72:1218-23
  9. Masini E, Di Bello MG, Raspanti S, Ndisang JF, Baronti R, Cappugi P, et al. The role of histamine in platelet aggregation by physiological and immunological stimuli. Inflamm Res 1998;47:211-20
  10. Szczeklik A, Milner PC, Birch J, Watkins J, Martin JF. Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Thromb Haemost 1986;56:283-7
  11. Chandrashekar L, Rajappa M, Sundar I, Munisamy M, Ananthanarayanan PH, Thappa DM, et al. Platelet activation in chronic urticaria and its correlation with disease severity. Platelets 2014;25:162-5
  12. Kasperska-Zajac A, Grzanka A, Jarzab J, Misiolek M, Wyszynska-Chlap M, Kasperski J, et al. The association between platelet count and acute phase response in chronic spontaneous urticaria. Biomed Res Int 2014;650913
  13. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: A simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32
  14. Singh H, Chaudhary R, Ray V. Platelet indices as quality markers of platelet concentrates during storage. Clin Lab Haematol 2003;25:307-10
  15. Akelma AZ, Mete E, Cizmeci MN, Kanburoglu MK, Malli DD, Bozkaya D. The role of mean platelet volume as an inflammatory marker in children with chronic spontaneous urticaria. Allergol Immunopathol (Madr) 2015;43:10-3
  16. Zuberbier T, Aberer W, Asero R, Bindslev-Jensen C, Brzoza Z,