SavedAdd your journal

Journals / Astım Allerji İmmünoloji / 2017 / Cilt: 15 - Sayı: 3

Acute Acneiform Eruption Related to Cetuximab Treated Successfully with Oral Tetracycline

Setuksimaba Bağlı Akut Akneiform Erüpsiyonun Oral Tetrasiklinle Başarılı Tedavisi

Handan BİLEN
Şevki ÖZDEMİR
ÖMER FARUK ELMAS
Okan KIZILYEL
Mahmut Sami METİN
Pages
160–163
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We reported this case to share that it is possible to treat acneiform eruption related to cetuximab with oral tetracycline, topical ketoconazole, local clindamycin phosphate and benzoyl peroxide.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The most common known causes of acneiform lesions secondary to chemotherapy are epidermal growth factor receptor (EGFR) inhibitors.
📊
Key Findings & Data:We reported a 59-year-old man who presented with sudden acneiform lesions on his face, neck and chest at the 8th day of cetuximab treatment which was used for metastatic colon cancer.
💡
Conclusion & Impact:We reported this case to share that it is possible to treat acneiform eruption related to cetuximab with oral tetracycline, topical ketoconazole, local clindamycin phosphate and benzoyl peroxide.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The most common known causes of acneiform lesions secondary to chemotherapy are epidermal growth factor receptor (EGFR) inhibitors. Cetuximab and panitumumab which are monoclonal antibodies and gefitinib and erlotinib which are tyrosine kinase inhibitors are the major drugs in this group. An acneiform lesion is the most common and the earliest reaction among the dermatological side effects related to EGFR inhibitors. Acneiform eruption, asthenia, stomach ache and nausea-vomiting are side effects related to cetuximab. We reported a 59-year-old man who presented with sudden acneiform lesions on his face, neck and chest at the 8th day of cetuximab treatment which was used for metastatic colon cancer. We reported this case to share that it is possible to treat acneiform eruption related to cetuximab with oral tetracycline, topical ketoconazole, local clindamycin phosphate and benzoyl peroxide.

Özet

Kemoterapi ilaçlarına bağlı akneiform döküntünün en iyi bilinen nedeni epidermal büyüme faktör reseptör (EBFR) inhibitörleridir. Bu ilaç grubunda başlıca monoklonal antikorlar olan setuksimab ve panitumumab, tirozin kinaz inhibitörleri olan gefitinib ve erlotinib yer alır. EBFR inhibitörlerine bağlı dermatolojik yan etkiler içinde akneiform döküntü en sık ve en erken görülen reaksiyondur. Setuksimaba bağlı başlıca yan etkiler; akneiform erüpsiyon, asteni, karın ağrısı ve bulantı-kusmadır. Yazıda metastatik kolon kanseri tedavisi için setuksimab tedavisi başlanan hastada, tedavinin sekizinci günü ani gelişen yüz, boyun ve göğüste akneiform lezyonları olan 59 yaşında erkek hastayı sunuyoruz. Setuksimaba bağlı akneiform erüpsiyon tedavisinde oral tetrasiklin, topikal ketokonazol ve lokal klindamisin fosfat ve benzoil peroksit karışımı ile başarılı bir tedavinin mümkün olduğunu paylaşmak için bu olguyu sunmayı uygun gördük.

🔖

Cite This Article

BİLEN, H., ÖZDEMİR, Ş., ELMAS, Ö. F., KIZILYEL, O., METİN, M. S. (2017). Acute Acneiform Eruption Related to Cetuximab Treated Successfully with Oral Tetracycline. Astım Allerji İmmünoloji, Cilt: 15 - Sayı: 3, 160–163. https://ajindex.com/articles/147394

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Wehler TC, Graf C, Möhler M, Herzog J, Berger MR, Gockel I, et al. Cetuximab-induced skin exanthema: Prophylactic and reactive skin therapy are equally effective. J Cancer Res Clin Oncol 2013;139:1667-72
  2. Busam KJ, Capodieci P, Motzer R, Kiehn T, Phelan D, Halpern AC. Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br J Dermatol 2001;144:1169-76
  3. Arıcan Ö, Önver N. Setuksimab tedavisine bağlı akneiform erüpsiyon: Bir olgu sunumu. Turk J Dermatol 2011;5:29-32
  4. Takcı Z, Seçkin HY, Arıcı A. Setuksimabın neden olduğu akneiform erüpsiyon. http://www.dermatoz.org/2014/3/ dermatoz14053o4. doi: 10.15624.dermatoz14053o4 5. Yazganoğlu KD, Baykal C. Hedefe yönelik kemoterapi ilaçlarına bağlı akneiform döküntü ve eşlik eden diğer dermatolojik yan etkiler: Retrospektif bir değerlendirme. Türkderm 2012;46:84-9
  5. Metin MS, Kızılyel O, Elmas ÖF, Aktaş A. Erlotinibe bağlı gelişen akneiform erüpsiyon: Bir olgu sunumu. Cumhuriyet Tıp Derg 2013;35(Ek sayı):35-37
  6. Hu JC, Sadeghi P, Pinter-Brown LC, Yashar S, Chiu MW. Cutaneous side effects of epidermal growth factor receptor inhibitors: Clinical presentation, pathogenesis, and management. J Am Acad Dermatol 2007;56:317-26
  7. Ocvirk J, Cencelj S. Management of cutaneous side effects of cetuximab therapy in patients with metastatic colorectal cancer. J Eur Acad Dermatol Venereol 2010:24:453-9
  8. Lee JE, Lee SJ, Lee HJ, Lee JH, Lee KH. Severe Acneiform Eruption Induced by Cetuximab (Erbitux®). Yonsei Med J 2008;49:851-2
  9. Sipples R. Common side effects of anti-EGFR therapy: Acneiform rash. Semin Oncol Nurs 2006;22:28-34
  10. Kuş S, Uygur T, Candan İ. Kolorektal kanser tedavisinde kullanılan Setuksimab'a bağlı akneiform erüpsiyon. Turkderm 2006;40(Özel Ek B):B85-7
  11. Tomková H, Kohoutek M, Zábojníková M, Pospísková M, Ostrízková L, Gharibyar M. Cetuximab-induced cutaneous toxicity. J Eur Acad Dermatol Venereol 2010;24:692-6
  12. Nakamura S, Hashimoto Y, Nishi K, Mizumoto T, Takahashi H, Iizuka H. Clinical response of acneiform eruptions caused by cetuximab to administration of oral tetracycline and topical ketoconazole. J Dermatol Case Rep 2014;31;8:16-9.