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Journals / Black Sea Journal of Health Science / 2022 / Cilt: 5 Sayı: 3

Analysis of the Effectiveness of First Trimester Nucal Translucence, Free Beta-Human Chorionic Gonadotropin, and Pregnancy-Related Plasma Protein-A in Prediction of Pregnancy Complications

Kamuran Suman(Afyonkarahisar Devlet Hastanesi)0000-0003-1814-7513
Zafer Bütün(Eskişehir Şehir Hastanesi)0000-0001-5297-4462
Musa Büyük(Afyonkarahisar Çay Devlet Hastanesi)0000-0003-1397-9273
Murat Suman(Afyon Çay Devlet Hastanesi)0000-0002-7078-9970
Banu Dane(Kanuni Sultan Süleyman Education and Research Hospital)0000-0002-0220-8660
Pages
533–539
Publication Date
2022-09-01
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There is a significant correlation between first trimester PAPP-A and β-hCG levels and birth weight.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, we aimed to investigate whether there was an association between fetal nuchal translucency (NT) and the serum markers plasma protein-A (PAPP-A) and free beta-human chorionic gonadotropin (β-hCG) measured by the first-trimester screening test, as well as birth weight and hypertension. 454 pregnant women who had undergone the first-trimester screening test for Down syndrome were included in the study.
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Key Findings & Data:All measurements and values of NT, PAPP-A and β-hCG levels were performed between gestational weeks 11-14.
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Conclusion & Impact:There is a significant correlation between first trimester PAPP-A and β-hCG levels and birth weight.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:First trimester · PAPP-A · β-hCG

Abstract

In this study, we aimed to investigate whether there was an association between fetal nuchal translucency (NT) and the serum markers plasma protein-A (PAPP-A) and free beta-human chorionic gonadotropin (β-hCG) measured by the first-trimester screening test, as well as birth weight and hypertension. 454 pregnant women who had undergone the first-trimester screening test for Down syndrome were included in the study. All measurements and values of NT, PAPP-A and β-hCG levels were performed between gestational weeks 11-14. Values of PAPP-A and β-hCG converted to multiples of the corrected median (MoM) were obtained using the PRISCA software package. Regarding the prediction of SGA infants, when the PAPP-A value < was 0.99MoM as a threshold, and when the free β-hCG value < was 0.69 MoM, SGA cases could be detected with a sensitivity of 83% and a specificity of 71.9%. Regarding the prediction of hypertension, at a threshold PAPP-A value of <of 0.96 MoM, cases of hypertension could be detected with a sensitivity of 70% and a specificity of 74%. Maternal PAPP-A level in the first trimester was found to correlate with neonatal birth weight (rho: 0.56 (95% CI 0.49-0.62), P < 0.0001), while β-hCG showed a weak but significant correlation with birth weight (rho: 0.137 (95% CI 0.045.) -0.227), P: 0.0036). Low PAPP-A levels in the first trimester were an effective predictor of SGA babies and hypertension, while low β-hCG levels were an effective predictor of SGA babies. There is a significant correlation between first trimester PAPP-A and β-hCG levels and birth weight.

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Cite This Article

Suman, K., Bütün, Z., Büyük, M., Suman, M., Dane, B. (2022). Analysis of the Effectiveness of First Trimester Nucal Translucence, Free Beta-Human Chorionic Gonadotropin, and Pregnancy-Related Plasma Protein-A in Prediction of Pregnancy Complications. Black Sea Journal of Health Science, Cilt: 5 Sayı: 3, 533–539. https://doi.org/10.19127/bshealthscience.1089239

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