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Journals / Black Sea Journal of Health Science / 2026 / Cilt: 9 Sayı: 4

Tamanu Oil (Calophyllum inophyllum) as a Natural Therapeutic Agent: Current Evidence on Wound Healing

Doğal Bir Terapötik Ajan Olarak Tamanu Yağı (Calophyllum inophyllum): Yara İyileşmesi Üzerine Güncel Kanıtlar

Fatma Zehra Ağan(HARRAN ÜNİVERSİTESİ)0000-0002-3784-8553
Pages
162–167
Publication Date
2026-07-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, further well-designed clinical studies are required to confirm the efficacy and safety of tamanu oil in wound management.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Wound healing is a complex biological process consisting of inflammation, proliferation, and remodeling phases.
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Key Findings & Data:Chronic wounds, diabetic ulcers, and infected wounds constitute a significant health problem today.
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Conclusion & Impact:Therefore, further well-designed clinical studies are required to confirm the efficacy and safety of tamanu oil in wound management.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Tamanu yağı · Calophyllum inophyllum · Yara iyileşmesi

Abstract

Wound healing is a complex biological process consisting of inflammation, proliferation, and remodeling phases. Chronic wounds, diabetic ulcers, and infected wounds constitute a significant health problem today. In recent years, interest in the potential effects of natural products on wound healing has increased. Tamanu oil, a natural oil obtained from the kernels of the Calophyllum inophyllum tree, has been used in traditional medicine for many years. Thanks to its calophyllolide, inophyllum compounds, flavonoids, and fatty acids, it exhibits anti-inflammatory, antioxidant, antimicrobial, and tissue-regenerating properties. In this review, the effects of tamanu oil on wound healing, its mechanisms of action, experimental studies, and current clinical evidence are evaluated in light of the current literature. Current evidence suggests that tamanu oil may support the wound healing process through its anti-inflammatory, antioxidant, and antimicrobial properties. Its potential effects on fibroblast proliferation, collagen synthesis, and modulation of inflammatory responses are particularly noteworthy. However, most of the available evidence is derived from experimental studies, while clinical investigations in humans remain limited. Therefore, further well-designed clinical studies are required to confirm the efficacy and safety of tamanu oil in wound management.

Özet

Yara iyileşmesi; inflamasyon, proliferasyon ve yeniden şekillenme fazlarından oluşan kompleks bir biyolojik süreçtir. Kronik yaralar, diyabetik ülserler ve enfekte yaralar günümüzde önemli bir sağlık problemi oluşturmaktadır. Son yıllarda doğal ürünlerin yara iyileşmesindeki potansiyel etkileri üzerine ilgi artmıştır. Tamanu Yağı, Calophyllum inophyllum ağacının çekirdeklerinden elde edilen doğal bir yağ olup geleneksel tıpta uzun yıllardır kullanılmaktadır. İçeriğinde bulunan calophyllolide, inophyllum bileşikleri, flavonoidler ve yağ asitleri sayesinde antiinflamatuvar, antioksidan, antimikrobiyal ve doku yenileyici özellikler göstermektedir. Bu derlemede tamanu yağının yara iyileşmesi üzerindeki etkileri, etki mekanizmaları, deneysel çalışmalar ve mevcut klinik kanıtlar güncel literatür eşliğinde değerlendirilmiştir. Mevcut bulgular, tamanu yağının antiinflamatuvar, antioksidan ve antimikrobiyal özellikleri sayesinde yara iyileşme sürecini destekleyebileceğini göstermektedir. Özellikle fibroblast proliferasyonu, kollajen sentezi ve inflamatuvar yanıtın düzenlenmesi üzerindeki etkileri dikkat çekmektedir. Bununla birlikte mevcut kanıtların büyük kısmı deneysel çalışmalara dayanmaktadır ve insanlarda gerçekleştirilen klinik araştırmalar sınırlıdır. Bu nedenle tamanu yağının yara tedavisindeki etkinliğinin ve güvenliliğinin doğrulanabilmesi için daha kapsamlı klinik çalışmalara ihtiyaç bulunmaktadır.

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Cite This Article

Ağan, F. Z. (2026). Tamanu Oil (Calophyllum inophyllum) as a Natural Therapeutic Agent: Current Evidence on Wound Healing. Black Sea Journal of Health Science, Cilt: 9 Sayı: 4, 162–167. https://doi.org/10.19127/bshealthscience.1954538

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