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Journals / Balıkesir Sağlık Bilimleri Dergisi / 2026 / Volume: 15 Issue: 1

The Clinical Course of Hypoxemia and Laboratory Test Results in Intensive Care Patients Diagnosed with COVID-19 and Receiving Oxygen Support

COVİD-19 Tanılı Oksijen Desteği Alan Yoğun Bakım Hastalarında Hipokseminin ve Laboratuvar Test Sonuçlarının Klinik Seyri

Yasemin Bozkurt Turan(Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi)0000-0003-3283-3587
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Publication Date
2026-02-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The median survival time was 18 [16.5–19.5] days, and the overall probability of survival for 28 days was 0.29 [0.25–0.34].

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The coronavirus disease 2019 (COVID-19) mortality rate could be affected by such factors as blood cell counts, hematological markers, and comorbidities.
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Key Findings & Data:Materials and Methods: This retrospective, cross-sectional, single-center study involved patients aged 18 and over, diagnosed with COVID-19, and admitted to a tertiary intensive care unit.
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Conclusion & Impact:The median survival time was 18 [16.5–19.5] days, and the overall probability of survival for 28 days was 0.29 [0.25–0.34].
🔬Design:Modeling & Simulation
📍Scope:2019 Verileri
⚙️Variables:Biomarker · Covid-19 · Hypoxemia

Abstract

Objective: The coronavirus disease 2019 (COVID-19) mortality rate could be affected by such factors as blood cell counts, hematological markers, and comorbidities. This study investigated the relationships between these factors and mortality. Materials and Methods: This retrospective, cross-sectional, single-center study involved patients aged 18 and over, diagnosed with COVID-19, and admitted to a tertiary intensive care unit. Results: The patients’ median age was 70 (58-79) years, and more than half were men (n=238, 57.6%). Mortality occurred in the majority of cases (n=331, 80.2%), and the median length of stay in the intensive care unit was 17 (8-28) days. The majority of the patients had comorbidities (n=318, 77.6%). The median survival time was 18 [16.5–19.5] days, and the overall probability of survival for 28 days was 0.29 [0.25–0.34]. In the time-dependent Cox regression model, age over 70 (HR=1.87[1.45–2.42]; p<0.001), male gender (HR=2.58[1.70–3.91]; p<0.001), the presence of comorbidities (HR=6.84[3.41–13.72]; p<0.001), leukocyte levels exceeding 15,200/µL (HR=1.61[1.25–2.08]; p<0.001), and C-reactive protein (CRP) levels higher than 102 mg/L (HR=1.63[1.23–2.16]; p=0.001) were significantly associated with mortality. Conclusion: Leukocyte and CRP elevation, a low ROX index, advanced age, male gender, and the presence of comorbidities all predict mortality in hypoxemic COVID-19 patients admitted to the ICU.

Özet

Amaç: Koronavirüs hastalığı 2019 (COVID-19) da mortalite oranı kan hücre sayısı, hematolojik belirteçler ve komorbiditeler gibi faktörlerden etkilenebilir. Çalışmada bu faktörler ile mortalite arasındaki ilişkinin araştırılması amaçlandı. Gereç ve Yöntem: Çalışma üçüncü basamak yoğun bakım ünitesine kabul edilen COVID-19 tanılı, 18 yaş üstü hastalarda retrospektif, kesitsel ve tek merkezli olarak yapıldı. Bulgular: Hastaların ortanca yaşı 70 (58-79) ve yarısından fazlası erkekti (n=238, %57.6). Hastaların çoğu öldü (n=331, %80.2) ve yoğun bakım ünitesinde ortanca kalış süresi 17 (8-28) gündü. Hastaların çoğunda komorbidite olup (n=318, %77.6), ortanca sağkalım süresi 18 [16.5–19.5] gün, 28 gün için genel sağkalım olasılığı 0.29 [0.25–0.34] olarak hesaplanmıştır. Zamana bağlı Cox regresyon modelinde, 70 yaş üstü (HR=1.87[1.45–2.42]; p<0.001), erkek cinsiyet (HR=2.58[1.70–3.91]; p<0.001), komorbidite varlığı (HR=6.84[3.41–13.72]; p<0. 001), 15.200/µL'yi aşan lökosit düzeyleri (HR=1.61[1.25–2.08]; p<0.001) ve 102 mg/L'den yüksek C-reaktif protein (CRP) düzeyleri (HR=1.63[1.23–2.16]; p=0.001) mortalite ile anlamlı şekilde ilişkili bulunmuştur. Sonuç: Hipoksemik COVID-19 tanılı yoğun bakım hastalarında lökosit ve CRP yüksekliği, düşük ROX indeksi, ileri yaş, erkek cinsiyet ve komorbidite varlığı mortaliteyi öngörmektedir.

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Cite This Article

Turan, Y. B. (2026). The Clinical Course of Hypoxemia and Laboratory Test Results in Intensive Care Patients Diagnosed with COVID-19 and Receiving Oxygen Support. Balıkesir Sağlık Bilimleri Dergisi, Volume: 15 Issue: 1. https://doi.org/10.53424/balikesirsbd.1685251

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