Journals / Aydın Sağlık Dergisi / 2026 / Cilt: 2 Sayı: 1

The Comparison of the Effects of Remifentanil in Combination with Sevoflurane, Desflurane or Propofol on Cognitive Functions in Elective Surgical Procedures

Pages
17–35
Publication Date
2016-04-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We aimed to compare the effects of remifentanil in combination with sevoflurane, desflurane or propofol on haemodynamic variables, post anaesthesia recovery and cognitive functions in patients for whom head and neck surgery were planned

📌 3 Key Takeaways

🎯
Objective & Hypothesis: Cognitive functions are affected by varying degrees after general anaesthesia.
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Key Findings & Data: Cognitive functions are affected by varying degrees after general anaesthesia.
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Conclusion & Impact:We aimed to compare the effects of remifentanil in combination with sevoflurane, desflurane or propofol on haemodynamic variables, post anaesthesia recovery and cognitive functions in patients for whom head and neck surgery were planned
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:This clinical research was performed on 60 patients · ASA I-II · aged 20-60 years with at least 8 years of education who would undergo elective surgical operations under general anaesthesia

Özet

 Cognitive functions are affected by varying degrees after general anaesthesia. We aimed to compare the effects of remifentanil in combination with sevoflurane, desflurane or propofol on haemodynamic variables, post anaesthesia recovery and cognitive functions in patients for whom head and neck surgery were planned

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Cite This Article

Türkmen, S. K., Türkmen, Ü. A., Moralar, D. G., Kalyon, S., Tekin, E. A. (2016). The Comparison of the Effects of Remifentanil in Combination with Sevoflurane, Desflurane or Propofol on Cognitive Functions in Elective Surgical Procedures. Aydın Sağlık Dergisi, Cilt: 2 Sayı: 1, 17–35. https://ajindex.com/articles/1458725

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References (47)

  1. Mashour GA, Forman SA, Campagna JA. Mechanisms of general anesthesia: frommolecules to mind. Best Pract Res Clin Anaesthesiol 2005; 19: 349–64
  2. Heinke W, Koelsch S. The effects of anesthetics on brain activity and cognitive function. Curr Opin Anaesthesiol 2005;18(6):625–31
  3. Hanning CD. Postoperative cognitive dysfunction. Br J Anaesth 2005; 95(1):82-7
  4. Hope AT, Woolman PS, Gray WM, Asbury AJ, Millar KA. A System for Psychomotor Evaluation Design, Implementation and Practice Effects in Volunteers. Anaesthesia 1998; 53:545–50
  5. KaracaS. Postoperatif Kognitif Fonksiyon Bozuklukları. TARK 2004 Özet Kitabı,57
  6. Tzabar Y, Asbury A J, Millar K. Cognitive Failures After General Anesthesia for Day- Case Surgery. Br J Anaesth 1996;76:194–7
  7. Motsch J, Breitbarth J, Salzman R, Bach A, Martin E. Kognitive und Psychomotorische Leistungsföhigkeit nacht Isofluran-Midazolam/Alfentanil und Propofol-Anösthesia. Anaesthesist 1992; 41:185–91
  8. Rasmussen LS. Postoperative cognitive dysfunction: incidence and prevention. Best Pract Res ClinAnaesthesiol 2006; 20:315–30
  9. Ancelin ML, De Roquefeuil G, Ritchie K. Anesthesia and postoperative cognitive dysfunction in the elderly: a review of clinical and epidemiological observations Rev Epidemiol Sante Publique 2000; 48: 459–72
  10. Butterfield NN, Graf P, Ries CR, MacLeod BA. The effect of repeated isoflurane anesthesia on spatial and psychomotor performance in young and aged mice. Anesth Analg 2004; 98:1305–11
  11. Culley DJ, Baxter M, Yukhananov R, Crosby G. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg 2003; 96:1004–9
  12. Kleinschmdt S, Grundmann U, Rauber K: Anesthsia with remifentanil combined with desflurane or sevoflurane in intervertebral disk operations. Anaesthesiol Reanim 2000; 25:151-157
  13. Larsen B, A Seitz and R Larsen. Recovery of Cognitive Function After Remifentanil-Propofol Anesthesia: A Comparison with Desflurane and Sevoflurane Anesthesia. Anesth Analg 2000;90:168–74
  14. Nishikawa K, Nakayama M, Omote K, Namiki A. Recovery characteristics and postoperative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia. Acta Anaesthesiol Scand 2004; 48:162–8
  15. Marshall SI, Chung F. Discharge criteria and complications after ambulatory surgery. Anesth Analg 1999; 88:508-517
  16. Vlymen JM, White PF. Outpatient anesthesia. In: Miller RD, ed. Anesthesia, 5th edition. Pennsylvania, USA: Churchill Livingstone; 2000; 2213-2246
  17. Tombaugh TN, Mc Intyre NI. The mini-mental state examination: a comprehensive review. J Am GerSoc 1992; 40:922-935
  18. Moller JT, Svenild I et al. Perioperative Monitoring With Pulse Oximetry And Late Postoperative Cognitive Dysfunction. BJ Anaesth 1993; 71: 340-47
  19. Pain L, Laaou FZ. Postanesthesia cognitive disfonksiyon. Presse Med 2009;38(11):1597-606
  20. Karan M. A, Vatansever S, Perioperatif İç Hastalıkları Konsültasyonu. İstanbul, Nobel Matbaacılık, 2003:134)
  21. Biedler A, Juckenhofel S, Larsen R et. al. Postoperative cognition disorders in elderly patients. The results of the “International Study of Postoperative Cognitive Dysfunction” (ISPOCD 1) Anaesthesist 1999; 48(2):884–95
  22. Deepak TS, Vadlamani S, Kumar KS et al. Postoperative cognitive functions after general anesthesia with sevoflurane and desflurane in South Asian elderly. Middle East J Anesthesiol 2013;22(2):143-8
  23. Tsai SK, Lee C et al. Recovery Of Cognitive Functions After Anesthesia With Desflurane Or Isoflurane And Nitrous Oxide. Br J Anaesth 1992; 69:255-58
  24. Graham SG, Aitkenhead AR.A comparison between propofol and desflurane anesthesia for minor gynaecological laparoscopic surgery. Anaesthesia 1993; 48:471-475
  25. White PF. Studies of desflurane in outpatient anesthesia. AnesthAnalg 1992;75:547-554
  26. Chen X, Zhao M, White PF, et al. The recovery of cognitive function after general anesthesia in elderly patients: A Comparison of desflurane and sevoflurane. Anesth Analg 2001; 93:1489-1494
  27. Wandel C, Neff S, Bohrer H, et al. Recovery characteristics following anaesthesia with sevoflurane or propofol in adults undergoing outpatient surgery. Eur J Clin Pharmacol 1995; 48(3-4):185-188
  28. Jellish WS, Lien CA, Fontenot HJ, Hall R. The comparative effects of sevoflurane versus propofol in the induction and maintainence of anaesthesia in adult patients. Anesth Analg 1996; 2:479-485
  29. Castagnini HE, Van Eijs F, Salevsky FC, Nathanson MH. Sevoflurane forinterventional neuroradiology procedures is associated with more rapid early recovery than propofol. Can J Anaesth 2004; 51:486-91
  30. Gupta A, Stierer T, Zuckerman R et al. Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: a systematic review. Anesth Analg 2004;98(3):632-41
  31. Pensado Castineiras A, Rama Maceiras P, Molins Gauna N, Fiqueira Moure A,Vasquez Fidalgo A. Immediate anesthesia recovery and psychomotor function of patient after prolonged anesthesia with desflurane, sevoflurane or isoflurane. Rev Esp Anestesiol Reanim 2000; 47: 386-92
  32. Van Hemelrijck J, Smith I, White PF. Use of desflurane for out patient anesthesia. Anesthesiology 1991;75:197-203
  33. Lebenbom-Mansour MH, Pandit SK, Kothary SP, et al. Desflurane versus propofol anesthesia: a comparative analysis in outpatients. Anesth Analg 1993; 76:936-941
  34. Dubin SA, Huang S, Martin E, List W. Multicenter comparative study evaluating sevoflurane versus propofol in anesthesia maintenance and recovery in adult outpatients. Anaesthesiology 1994; 81:2
  35. Heidi E, Korttila K. Recovery profile after desflurane with or without ondansetron compared with propofol in patients undergoing gynecological laparoscopy. AnesthAnalg 1996; 82:533-538
  36. Rodino S, Rama P, Pensado A, et al. Comparison of sevoflurane and propofol in the maintenance of and recovery from anesthesia. Rev Esp Anestesiol Reanim 1999; 46(10):427-32
  37. Parida S, Badhe AS. Comprasion of cognitive, ambulatory and psycomotor recovery profiles after day care anesthesia with propofol and sevoflurane. J Anesth 2014:19
  38. Ebert TJ, Robinson BJ, Uhrich TD, Mackenthun A, Pichotta PJ. Recovery from sevoflurane anesthesia: a comparison to isoflurane and propofol anesthesia. Anesthesiology 1998; 89: 1524-31
  39. Rosow CE. An overview of remifentanil. AnesthAnalg 1999; 89:1-3
  40. Loop T, Priebe HJ. Recovery after anesthesia with remifentanil combined withpropofol, desflurane, or sevoflurane for otorhinolaryngeal surgery. AnesthAnalg 2000; 91:123-129
  41. Hogue CW, Bowdle A, O’leary C. A multicenter evaluation of total intravenous anesthesia with remifentanil and propofol for elective inpatient surgery. AnesthAnalg 1996; 83:279-285
  42. Westmoreland CL, Hoke JF, et al. Pharmacokinetics of remifentanil and its major metabolite in patients undergoing elective inpatient surgery. Anesthesiology 1993;79:893-903
  43. Hoke JF, Cunningham F, James MK, et al. Comperative pharmacokinetics and pharmacodynamics of remifentanil, its principle metabolite (GR 90291) and alfentanil in dogs. J Pharmacol Exp Ther 1997;281:226-232
  44. Egan TD, Lemmens HJM, Fiset P, etal. The pharmacokinetics of the new short-acting opioid remifentanil (6187084B) in healthy adult male volunteers. Anesthesiology 1993:881-892
  45. Palazon H, Asensi P, Lopez S, et al. Comparison of anesthetic maintenance and recovery with propofol versus sevoflurane combined with remifentanil in craniotomy for supratentorial neoplasm. Rev Esp Anestesiol Reanim 2006; 53(2):88-94
  46. Karlsen KL, Persson E, Wennberg E, Stengvist O. Anesthesia, recovery andpostoperative nause and vomiting after breast surgery; a comparison between desflurane, sevoflurane and izoflurane anesthesia. Acta Anaesthesiol 2000 Apr; 44(4): 489-93
  47. Lee Y, Lin PC, Lai HY: Prevention of PONV with dexamethasone in femalepatients undergoing desflurane anesthesia for thyroidectomy. Acta Anaesthesiol Sin 2001; 39:151-156.