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Journals / Anatolian Current Medical Journal / 2026 / Volume: 6 Issue: 2

Relationship between coronary artery disease and high-density lipoprotein cholesterol-monocyte ratio

Eyüp Özkan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI)0000-0003-0792-628X
Aslan Erdoğan(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL BAŞAKŞEHİR ÇAM VE SAKURA ŞEHİR SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, KARDİYOLOJİ ANABİLİM DALI)0000-0002-1094-5572
Pages
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Publication Date
2024-03-08
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: HMR was an independent factor of CAD and can be used as a biomarker to evaluate the severity of CAD.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: To investigate the association between high-density lipoprotein cholesterol (HDL-C)-to- monocyte ratio(HMR) and coronary artery disease (CAD) proven by coronary angiography.
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Key Findings & Data:Methods: A total of 311 patients were enrolled in the retrospective study.
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Conclusion & Impact:Conclusion: HMR was an independent factor of CAD and can be used as a biomarker to evaluate the severity of CAD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Coronary artery disease · HDL-C-to-monocyte ratio · coronary angiography

Abstract

Aims: To investigate the association between high-density lipoprotein cholesterol (HDL-C)-to- monocyte ratio(HMR) and coronary artery disease (CAD) proven by coronary angiography. Methods: A total of 311 patients were enrolled in the retrospective study. The grouping was based on whether the stenosis of one coronary artery exceeds 50%. Gensini Score (GS) to evaluate the severity of coronary artery stenosis. Spearman correlation analysis, progressive logistic regression, and receiver operating characteristic (ROC) curve analysis were used. Results: The HMR difference between the CAD and non-CAD groups was statistically significant (P<0.001). Spearman correlation analysis showed that the HMR was slightly and moderately correlated with other independent risk factors of CAD (r<0.5). HMR was a new independent risk factor by progressive logistic regression analysis (odds ratio=0.784. 95% CI, 0.682-0.901). HMR was related to the GS of CAD patients (r=-0.244, P<0.001). Moreover, the HMR was better than HDL-C and HDL-C-to-cholesterol by comparing AUC (AUC HDL-C-to-monocyte=0.642, AUC HDL-C=0.603, AUC HDL-C-to-cholesterol=0.584). Conclusion: HMR was an independent factor of CAD and can be used as a biomarker to evaluate the severity of CAD.

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Cite This Article

Özkan, E., Erdoğan, A. (2024). Relationship between coronary artery disease and high-density lipoprotein cholesterol-monocyte ratio. Anatolian Current Medical Journal, Volume: 6 Issue: 2. https://doi.org/10.38053/acmj.1409450

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