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Journals / Anatolian Current Medical Journal / 2026 / Volume: 7 Issue: 4

Intraoperative perineural hyaluronic acid injection does not improve outcomes after carpal tunnel release in moderate-to-severe CTS: a retrospective cohort study

Mustafa Dinç(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, BURSA TIP FAKÜLTESİ, BURSA TIP PR.)0000-0002-3002-5028
Ömer Cevdet Soydemir(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, BURSA TIP FAKÜLTESİ)0000-0001-8493-8562
Recep Karasu(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, BURSA TIP FAKÜLTESİ, BURSA TIP PR.)0000-0002-0628-5794
Bilal Aykaç(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, BURSA TIP FAKÜLTESİ, BURSA TIP PR.)0000-0002-6180-2467
Hünkar Çağdaş Bayrak(çekirge state hospital)0009-0003-4963-9980
Pages
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Publication Date
2025-07-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings do not support routine use of intraoperative HA in advanced CTS but highlight the need for future prospective trials targeting earlier-stage disease, sustained-release formulations, or repeated dosing strategies.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: This study aims to evaluate whether intraoperative perineural hyaluronic acid (HA) injection provides additional clinical or electrophysiological benefits beyond standard carpal tunnel release (CTR) in patients with moderate-to-severe carpal tunnel syndrome (CTS).
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Key Findings & Data:Methods: In this retrospective cohort study, 130 patients with electrophysiologically confirmed moderate-to-severe CTS underwent either CTR alone (n=66) or CTR with intraoperative perineural HA injection (n=64).
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Conclusion & Impact:These findings do not support routine use of intraoperative HA in advanced CTS but highlight the need for future prospective trials targeting earlier-stage disease, sustained-release formulations, or repeated dosing strategies.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Carpal tunnel syndrome · hyaluronic acid · perineural injection

Abstract

Aims: This study aims to evaluate whether intraoperative perineural hyaluronic acid (HA) injection provides additional clinical or electrophysiological benefits beyond standard carpal tunnel release (CTR) in patients with moderate-to-severe carpal tunnel syndrome (CTS). Methods: In this retrospective cohort study, 130 patients with electrophysiologically confirmed moderate-to-severe CTS underwent either CTR alone (n=66) or CTR with intraoperative perineural HA injection (n=64). HA (Alsegovisc®, 40 mg/2 ml, 1500 kDa) was administered following surgical decompression. Outcomes included pain (Visual Analog Scale, VAS), symptom severity and function (Boston Carpal Tunnel Questionnaire, BCTQ), sensory and motor conduction (SNCV, DML), and achievement of patient-centered benchmarks (minimal clinically important difference, MCID; patient acceptable symptom state, PASS). Evaluations were carried out pre-surgically and at 3- and 6-month intervals following the procedures. Results: Both groups demonstrated significant improvements in pain (VAS: 7.0 to 2.0), symptom severity (BCTQ-SSS: 45.0 to 18.0), function (BCTQ-FSS: 34.5 to 13.5), and electrophysiological parameters (SNCV: 31.4 to 40.5 m/s; DML: 5.5 to 4.2 ms) over 6 months (all p 0.05), and effect sizes were consistently small (Cohen’s d 68% of patients in both groups. Subgroup analyses revealed no predictive value for baseline disease severity or thenar atrophy. Conclusion: Intraoperative perineural HA injection did not confer additional clinical or electrophysiological benefit over CTR alone in moderate-to-severe CTS. Despite compelling preclinical data, HA's efficacy may be attenuated in chronic fibrotic nerve compression due to pharmacokinetic and tissue-level limitations. These findings do not support routine use of intraoperative HA in advanced CTS but highlight the need for future prospective trials targeting earlier-stage disease, sustained-release formulations, or repeated dosing strategies.

Özet

Aims: This study aims to evaluate whether intraoperative perineural hyaluronic acid (HA) injection provides additional clinical or electrophysiological benefits beyond standard carpal tunnel release (CTR) in patients with moderate-to-severe carpal tunnel syndrome (CTS). Methods: In this retrospective cohort study, 130 patients with electrophysiologically confirmed moderate-to-severe CTS underwent either CTR alone (n=66) or CTR with intraoperative perineural HA injection (n=64). HA (Alsegovisc®, 40 mg/2 ml, 1500 kDa) was administered following surgical decompression. Outcomes included pain (Visual Analog Scale, VAS), symptom severity and function (Boston Carpal Tunnel Questionnaire, BCTQ), sensory and motor conduction (SNCV, DML), and achievement of patient-centered benchmarks (minimal clinically important difference, MCID; patient acceptable symptom state, PASS). Evaluations were carried out pre-surgically and at 3- and 6-month intervals following the procedures. Results: Both groups demonstrated significant improvements in pain (VAS: 7.0 to 2.0), symptom severity (BCTQ-SSS: 45.0 to 18.0), function (BCTQ-FSS: 34.5 to 13.5), and electrophysiological parameters (SNCV: 31.4 to 40.5 m/s; DML: 5.5 to 4.2 ms) over 6 months (all p 0.05), and effect sizes were consistently small (Cohen’s d 68% of patients in both groups. Subgroup analyses revealed no predictive value for baseline disease severity or thenar atrophy. Conclusion: Intraoperative perineural HA injection did not confer additional clinical or electrophysiological benefit over CTR alone in moderate-to-severe CTS. Despite compelling preclinical data, HA's efficacy may be attenuated in chronic fibrotic nerve compression due to pharmacokinetic and tissue-level limitations. These findings do not support routine use of intraoperative HA in advanced CTS but highlight the need for future prospective trials targeting earlier-stage disease, sustained-release formulations, or repeated dosing strategies.

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Cite This Article

Dinç, M., Soydemir, Ö. C., Karasu, R., Aykaç, B., Bayrak, H. Ç. (2025). Intraoperative perineural hyaluronic acid injection does not improve outcomes after carpal tunnel release in moderate-to-severe CTS: a retrospective cohort study. Anatolian Current Medical Journal, Volume: 7 Issue: 4. https://doi.org/10.38053/acmj.1707263

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