Journals / Anatolian Current Medical Journal / 2026 / Volume: 8 Issue: 3

Neurocognitive correlates of functional impairment in COPD: the roles of sluggish cognitive tempo and cognitive flexibility

Meltem Hazel Şimşek(Giresun University, Faculty of Medicine, Department of Psychiatry)0000-0002-3323-4116
Selda Günaydın(Giresun University, Faculty of Medicine, Department of Chest Diseases)0000-0001-5641-012X
Hayriye Bektaş Aksoy(Giresun University, Faculty of Medicine, Department of Chest Diseases)0000-0002-4390-5198
Şaban Melih Şimşek(Giresun University, Faculty of Medicine, Department of Chest Diseases)0000-0002-2897-2421
Pages
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Publication Date
2026-05-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Decreased cognitive flexibility may be associated with functional impairment through increased symptom perception and slowed cognitive tempo.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: The present study aims to examine differences in cognitive flexibility and sluggish cognitive tempo (SCT) levels in individuals diagnosed with Chronic obstructive pulmonary disease (COPD) according to disease stage and to evaluate the independent and indirect relationships of these cognitive processes on daily functioning.
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Key Findings & Data:Methods: The cross-sectional study included 162 COPD patients classified according to GOLD 2024 criteria (GOLD A=46, GOLD B=55, GOLD E=61).
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Conclusion & Impact:Decreased cognitive flexibility may be associated with functional impairment through increased symptom perception and slowed cognitive tempo.
🔬Design:Modeling & Simulation
📍Scope:2024 Verileri
⚙️Variables:Chronic obstructive pulmonary disease · sluggish cognitive tempo · cognitive flexibility

Abstract

Aims: The present study aims to examine differences in cognitive flexibility and sluggish cognitive tempo (SCT) levels in individuals diagnosed with Chronic obstructive pulmonary disease (COPD) according to disease stage and to evaluate the independent and indirect relationships of these cognitive processes on daily functioning. Methods: The cross-sectional study included 162 COPD patients classified according to GOLD 2024 criteria (GOLD A=46, GOLD B=55, GOLD E=61). Participants were administered the SCT Scale, Cognitive Flexibility Inventory (CFI), Hospital Anxiety and Depression Scale (HADS), COPD Assessment Test (CAT), and Functional Assessment Short Scale (FAST). Variables predicting daily functioning and SCT were examined using hierarchical regression analyses; mediating relationships were assessed using the PROCESS macro. Results: SCT levels were significantly higher in advanced COPD groups (p=0.015). In hierarchical regression, SCT was the strongest predictor of daily functioning (β=0.35, p 0.05). Simple mediation analysis showed that the effect of cognitive flexibility on functionality occurred through SCT (indirect effect=-0.179, 95% CI [-00.261, -0.105]). In the serial mediation model, the path CFI → CAT → SCT → FAST was found to be significant (indirect effect=-0.078, 95% CI [-0.140, -0.029]). Conclusion: In COPD, daily functioning is related more to symptom burden and especially SCT than to spirometric severity. Decreased cognitive flexibility may be associated with functional impairment through increased symptom perception and slowed cognitive tempo.

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Cite This Article

Şimşek, M. H., Günaydın, S., Aksoy, H. B., Şimşek, Ş. M. (2026). Neurocognitive correlates of functional impairment in COPD: the roles of sluggish cognitive tempo and cognitive flexibility. Anatolian Current Medical Journal, Volume: 8 Issue: 3. https://doi.org/10.38053/acmj.1896221

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