Journals / Anatolian Current Medical Journal / 2026 / Volume: 8 Issue: 3

Dried yogurt and quinoa attenuate neurodegeneration and cranial bone alterations in protein-deficient rats: a histopathological and radiological study

Vatan Kavak(DICLE UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-5287-4485
Doğan Kurt(DICLE UNIVERSITY, FACULTY OF VETERINARY)0000-0002-0049-7809
Pages
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Publication Date
2026-05-22
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Conclusion: Dried yogurt and quinoa supplementation significantly enhanced body and brain weights in rat pups compared to 2% and 12% protein diets, particularly reversing the deficits observed in protein restricted cohorts.

📌 3 Key Takeaways

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Objective & Hypothesis:Aims: This study focuses on experimental studies conducted on rats to explain the effects of malnutrition and poor nutrition, dry yogurt diet, and quinoa diet on skull measurements.
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Key Findings & Data:Methods: Newborn rat pups were divided as a 2% protein diet, a 12% protein diet, a 24% protein diet, a dry yogurt diet, and a quinoa diet.
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Conclusion & Impact:Conclusion: Dried yogurt and quinoa supplementation significantly enhanced body and brain weights in rat pups compared to 2% and 12% protein diets, particularly reversing the deficits observed in protein restricted cohorts.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Low-protein diet · middle-protein diet · dry-yoghurt diet

Abstract

Aims: This study focuses on experimental studies conducted on rats to explain the effects of malnutrition and poor nutrition, dry yogurt diet, and quinoa diet on skull measurements. Methods: Newborn rat pups were divided as a 2% protein diet, a 12% protein diet, a 24% protein diet, a dry yogurt diet, and a quinoa diet. The diets were isocaloric and were administered from day 22 prenatal, the weaning period, until 90 days of age. Skull measurements were taken from lateral and anterior skull X-rays. Results: In the 22nd day of the 2% protein diet fed offspring rats, the average brain weight was 1.1550±0.094 and the average brain weight was 1.470±0.080 on the 90th day, p=0.001. The average body weight of the 22nd day of the 2% protein diet-fed baby rats was 19.20±3.238 and the average body weight was 95.461±6.233 on the 90th day. p=0.001. Significant changes in cranial structure were observed in 90-day-old rats fed diets containing 24%, 12%, and 2% protein, as well as dry yogurt and quinoa. Bone measurements were significantly shorter in low-protein diets. Skull length, facial length, nasal bone length, and Orbit length optic canal suture results in the 2% and 24% protein modeling were: 2.66±0.03-4.07±0.1, p<0.0001. 1.74±0.1-2.72±0.0, p<0.0001. 0.82±0.0-1.45±0.1, p<0.0001, and 0.11±0.0-0.13±0.1, p<0.0001, respectively. Conclusion: Dried yogurt and quinoa supplementation significantly enhanced body and brain weights in rat pups compared to 2% and 12% protein diets, particularly reversing the deficits observed in protein restricted cohorts.

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Cite This Article

Alan, B., Kavak, V., Kurt, D. (2026). Dried yogurt and quinoa attenuate neurodegeneration and cranial bone alterations in protein-deficient rats: a histopathological and radiological study. Anatolian Current Medical Journal, Volume: 8 Issue: 3. https://doi.org/10.38053/acmj.1887680

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References (16)

  1. Terreros G, Pérez MÁ, Muñoz-LLancao P, D'Espessailles A, Martínez EA, Dagnino-Subiabre A. The neuroprotective role of quinoa (Chenopodium quinoa Willd.) supplementation in hippocampal morphology and memory of adolescent stressed rats. Nutrients. 2024; 16(3):381. doi:10.3390/nu16030381
  2. Hu Y, Zhou J, Cao Y, Zhang J, Zou L. Anti-aging effects of polysaccharides from quinoa (Chenopodium quinoa Willd.) in improving memory and cognitive function. J Funct Foods. 2022;94:105097. doi:10.1016/j.jff.2022. 105097
  3. Pannerchelvan S, Rios-Solis L, Wasoh H, et al. Functional yogurt: a comprehensive review of its nutritional composition and health benefits. Food Funct. 2024;15(22):10927-10955. doi:10.1039/d4fo03671a
  4. Adams MS, Mensink RP, Joris PJ. Effects of dietary proteins on cognitive performance and brain vascular function in adults: a systematic review of randomised controlled trials. Nutr Res Rev. 2025;38(2):450-464. doi: 10.1017/S0954422424000271
  5. Roshankhah S, Sadeghi E, Jalili C, Salahshoor M. Impacts of low-protein diet on the hippocampal CA1 neurons and learning deficits in rats. Adv Hum Biol. 2019;9(2):124-128. doi:10.4103/AIHB.AIHB-31-19
  6. Lau-Cam CA. Protective role of taurine and structurally related compounds against diabetes-induced oxidative stress. In: Preedy VR, ed. Diabetes: Oxidative Stress and Dietary Antioxidants. 2nd ed. Academic Press. 2020:351-359. doi:10.1016/B978-0-12-815776-3.00036-X
  7. Prado EL, Dewey KG. Nutrition and brain development in early life. Nutr Rev. 2014;72(4):267-284. doi:10.1111/nure.12102
  8. Chertoff, MSJ. Protein malnutrition and brain development. Brain Disord Ther. 2015;4(3):1-6. doi:10.4172/2168-975X.1000171
  9. Garn SM, Rohmann CG, Behar M, Viteri F, Guzman MA. Compact bone deficiency in protein-calorie malnutrition. Science. 1964;145(3639):1444-1445. doi:10.1126/science.145.3639.1444
  10. Bonjour JP. Dietary protein: an essential nutrient for bone health. J Am Coll Nutr. 2005;24(6 Suppl):526S-536S. doi:10.1080/07315724.2005.10719501
  11. Lightfoot PS, German RZ. The effects of muscular dystrophy on craniofacial growth in mice: a study of heterochrony and ontogenetic allometry. J Morphol. 1998;235(1):1-16. doi:10.1002/(SICI)1097-4687(199801)235:1 3.0.CO;2-F
  12. Tatli M, Guzel A, Kizil G, Kavak V, Yavuz M, Kizil M. Comparison of the effects of maternal protein malnutrition and intrauterine growth restriction on redox state of central nervous system in offspring rats. Brain Res. 2007;1156:21-30. doi:10.1016/j.brainres.2007.04.036
  13. Kavak V, Babacan F, Celik F, Bilici A, Kara IH. The effect of ligation of the uterine artery and early postnatal food restriction-animal models for growth retardation on the rat. Liet Bendrosios Prakt Gydytojas. 2010; 14(2):98-105.
  14. Alamy M, Bengelloun WA. Malnutrition and brain development: an analysis of the effects of inadequate diet during different stages of life in rat. Neurosci Biobehav Rev. 2012;36(6):1463-1480. doi:10.1016/ j.neubiorev.2012.03.009
  15. Bonjour JP. Protein intake and bone health. Int J Vitam Nutr Res. 2011;81(2-3):134-142. doi:10.1024/0300-9831/a000063
  16. Gaffney-Stomberg E, Insogna KL, Rodriguez NR, Kerstetter JE. Increasing dietary protein requirements in elderly people for optimal muscle and bone health. J Am Geriatr Soc. 2009;57(6):1073-1079. doi:10. 1111/j.1532-5415.2009.02285.x