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Journals / ADO Klinik Bilimler Dergisi / 2026 / Cilt: 15 Sayı: 3

Peripheral Giant Cell Granuloma: A Case Report and Review of Pediatric Reactive Mucosal Lesions with Clinicopathological Correlations

Periferik Dev Hücreli Granülom: Çocuklarda Görülen Reaktif Oral Mukozal Lezyonların Klinikopatolojik Perspektiften Değerlendirilmesi ve Bir Olgu Sunumu

Ece Rakunt Toptaş(BAHÇEŞEHİR ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ)0000-0002-5683-5870
Özlem Özer Yücel(BAHÇEŞEHİR ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ)0009-0009-0171-2062
Pages
222–228
Publication Date
2026-09-25
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Early diagnosis, complete excision, elimination of etiological factors, and interdisciplinary follow-up are essential to minimize recurrence risk.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Introduction: Peripheral giant cell granuloma (PGCG) is an uncommon reactive lesion in children that may demonstrate aggressive behavior and recurrence.
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Key Findings & Data:Case Report: A 9-year-old boy presented with gingival enlargement in anterior maxilla.
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Conclusion & Impact:Early diagnosis, complete excision, elimination of etiological factors, and interdisciplinary follow-up are essential to minimize recurrence risk.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:periferik dev hücreli granülom · pediyatrik reaktif mukozal lezyonlar · histopataloji

Abstract

Introduction: Peripheral giant cell granuloma (PGCG) is an uncommon reactive lesion in children that may demonstrate aggressive behavior and recurrence. This study presents a pediatric case and provides a narrative review of reactive oral mucosal lesions in the pediatric population. Case Report: A 9-year-old boy presented with gingival enlargement in anterior maxilla. Clinical examination revealed excessive plaque accumulation along with rotational malalignment of the maxillary incisor and increased overjet, potentially contributing to plaque retention and chronic mechanical irritation. The lesion was surgically excised and histopathologically diagnosed as PGCG. Recurrence occurred at 11 weeks, requiring deeper excision. No further recurrence was observed during 18-month follow-up. Conclusion: The accompanying narrative review highlights differences in prevalence, histopathology, and recurrence tendencies among common pediatric reactive lesions. Compared with other entities, PGCG demonstrates a relatively higher recurrence potential. Early diagnosis, complete excision, elimination of etiological factors, and interdisciplinary follow-up are essential to minimize recurrence risk.

Özet

Giriş: Periferik dev hücreli granülom (PDHG), çocuklarda nadir görülen ancak agresif klinik seyir ve rekürrens gösterebilen reaktif bir lezyondur. Bu çalışma pediatrik bir olguyu sunmakta ve reaktif oral mukozal lezyonlara ilişkin bir derleme içermektedir. Olgu Sunumu: Dokuz yaşındaki erkek hasta üst anterior bölgede gingival büyüme şikâyetiyle başvurdu. Klinik muayenede yoğun plak birikimi ile birlikte maksiller kesicide rotasyon ve artmış overjet saptandı; bu durumun plak retansiyonu ve kronik mekanik irritasyona katkıda bulunabileceği değerlendirildi. Lezyon cerrahi olarak eksize edildi ve histopatolojik olarak PDHG tanısı doğrulandı. 11. haftada rekürrens izlenmesi üzerine daha derin eksizyon uygulandı. 18 aylık takipte yeniden rekürrens gözlenmedi. Sonuç: Pediatrik reaktif oral lezyonlar benzer etiyolojik faktörlere sahip olmakla birlikte biyolojik davranış ve rekürrens eğilimleri açısından farklılık gösterir. PDHG’nin görece yüksek rekürrens potansiyeli nedeniyle erken tanı, tam eksizyon ve multidisipliner takip önemlidir.

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Cite This Article

Toptaş, E. R., Yücel, Ö. Ö. (2026). Peripheral Giant Cell Granuloma: A Case Report and Review of Pediatric Reactive Mucosal Lesions with Clinicopathological Correlations. ADO Klinik Bilimler Dergisi, Cilt: 15 Sayı: 3, 222–228. https://doi.org/10.54617/adoklinikbilimler.1903339

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