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Journals / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 11 Sayı: 2

Preprocedural systemic inflammatory response index and monocyte to lymphocyte ratio as a predictor of coronary slow phenomenon

İşlem öncesi sistemik inflamatuar yanıt indeksi ve monosit-lenfosit oranının koroner yavaş akımın bir belirteci olarak değerlendirilmesi

Ahmet Karakurt(KARAMANOGLU MEHMETBEY UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-8877-100X
Oğuz Kılıç(KARAMANOGLU MEHMETBEY UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-5126-0959
Pages
112–121
Publication Date
2025-08-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Though predictive accuracy is moderate, they may serve as tools for pre-CAG assessment in identifying CSF.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To evaluate the potential of the systemic inflammation response index (SIRI) and the monocyte-to-lymphocyte ratio (MLR) as biomarkers for the coronary slow flow (CSF).
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Key Findings & Data:Materials and Methods: The study included 235 participants, comprising 128 patients diagnosed with CSF and 107 individuals with normal coronary flow.
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Conclusion & Impact:Though predictive accuracy is moderate, they may serve as tools for pre-CAG assessment in identifying CSF.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Koroner yavaş akım · İnflamasyon · Koroner anjiografi

Abstract

Aim: To evaluate the potential of the systemic inflammation response index (SIRI) and the monocyte-to-lymphocyte ratio (MLR) as biomarkers for the coronary slow flow (CSF). Materials and Methods: The study included 235 participants, comprising 128 patients diagnosed with CSF and 107 individuals with normal coronary flow. SIRI and MLR were calculated for all participants, and coronary flow velocities were assessed using the TIMI frame count method. Results: CSF patients had higher SIRI (p=0.011) and MLR (p=0.039) versus controls. ROC analysis revealed MLR had 63.2% sensitivity, 50% specificity (AUC=0.577), while SIRI showed 29.6% sensitivity, 89.6% specificity (AUC=0.597). Conclusion: Elevated SIRI and MLR are independently associated with CSF, offering simple, cost-effective pre-coronary angiography (CAG) biomarkers. Though predictive accuracy is moderate, they may serve as tools for pre-CAG assessment in identifying CSF.

Özet

Amaç: Sistemik inflamatuar yanıt indeksi (SIRI) ve monosit-lenfosit oranının (MLO), koroner yavaş akım (KYA) için biyobelirteç olarak potansiyelini değerlendirmek. Gereç ve Yöntem: Çalışmaya 128 KYA tanılı hasta ve 107 normal koroner akımlı birey olmak üzere toplam 235 katılımcı dahil edildi. Tüm katılımcılarda SIRI ve MLO hesaplandı; koroner akım hızları TIMI kare sayım yöntemiyle değerlendirildi. Bulgular: KYA grubunda SIRI (p=0,011) ve MLO (p=0,039) değerleri kontrol grubuna göre anlamlı derecede yüksek bulundu. ROC analizinde MLO'nun duyarlılığı %63,2, özgüllüğü %50 (AUC=0,577), SIRI'nin ise duyarlılığı %29,6, özgüllüğü %89,6 (AUC=0,597) olarak saptandı. Sonuç: Yüksek SIRI ve MLO düzeyleri KYA ile bağımsız olarak ilişkilidir. Koroner anjiyografi (KAG) öncesi değerlendirmede kullanılabilecek bu basit ve ekonomik biyobelirteçler, prediktif doğrulukları sınırlı olsa da KYA tanısında yardımcı araçlar olarak kullanılabilir.

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Cite This Article

Karakurt, A., Kılıç, O. (2025). Preprocedural systemic inflammatory response index and monocyte to lymphocyte ratio as a predictor of coronary slow phenomenon. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 11 Sayı: 2, 112–121. https://doi.org/10.30569/adiyamansaglik.1690495

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