SavedAdd your journal

Journals / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 12 Sayı: 1

Investigation of urocortin expression in endometrial tissue in women with unexplained infertility

Açıklanamayan infertilite olgularında endometriyal dokuda ürokortin ekspresyonunun araştırılması

Fatma Tanılır Çağıran(özel muayenehane)0000-0002-1460-6965
Sevil Çiçek(İSTANBUL MEDENİYET ÜNİVERSİTESİ)0000-0001-6147-8102
Zercan Kalı(Özel Gözde Hastanesi Malatya)0000-0002-7128-7550
Pınar Kırıcı(TURGUT OZAL UNIVERSITY)0000-0001-7616-4181
Hasan Çılgın(özel muayenehane)0000-0002-7279-5995
Pages
101–107
Publication Date
2026-04-23
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The decreased expression of urocortin in endometrial tissue of women with unexplained infertility suggests that the local inflammatory response involved in the implantation process may be insufficient.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: The aim of this study was to evaluate urocortin (Ucn) expression in endometrial tissue of women diagnosed with unexplained infertility and to compare the findings with those of fertile controls.
📊
Key Findings & Data:Materials and Methods: Fifty-four women with unexplained infertility who underwent hysteroscopic endometrial sampling for pregnancy achievement were included as Group 1.
💡
Conclusion & Impact:Conclusion: The decreased expression of urocortin in endometrial tissue of women with unexplained infertility suggests that the local inflammatory response involved in the implantation process may be insufficient.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Açıklanamayan infertilite · Ürokortin · Endometriyum

Abstract

Aim: The aim of this study was to evaluate urocortin (Ucn) expression in endometrial tissue of women diagnosed with unexplained infertility and to compare the findings with those of fertile controls. Materials and Methods: Fifty-four women with unexplained infertility who underwent hysteroscopic endometrial sampling for pregnancy achievement were included as Group 1. The control group (Group 2) consisted of endometrial biopsy samples obtained from 20 women with proven fertility who underwent tubal ligation. Urocortin expression was evaluated semi-quantitatively using immunohistochemical and immunoassay methods. Results: Endometrial tissue urocortin levels were found to be significantly lower in the unexplained infertility group compared with the control group (p<0.05). Conclusion: The decreased expression of urocortin in endometrial tissue of women with unexplained infertility suggests that the local inflammatory response involved in the implantation process may be insufficient.

Özet

Amaç: Bu çalışmanın amacı, açıklanamayan infertilite tanısı alan kadınlarda endometriyal dokuda ürokortin (Ucn) ekspresyonunu değerlendirmek ve fertil kontrol grubu ile karşılaştırmaktır. Gereç ve Yöntem: Çalışmaya, gebelik elde etmek amacıyla histeroskopi sırasında endometriyal doku örneklemesi yapılan açıklanamayan infertilite tanılı 54 kadın (Grup 1) dâhil edildi. Kontrol grubunu, tüp ligasyonu uygulanan ve fertilitesi kanıtlanmış 20 kadından alınan endometriyal biyopsi örnekleri oluşturdu. Ürokortin ekspresyonu immünohistokimyasal ve immünoassay yöntemleri ile yarı kantitatif olarak değerlendirildi. Bulgular: Endometriyal doku ürokortin düzeyleri, açıklanamayan infertilite grubunda kontrol grubuna göre anlamlı derecede daha düşük bulundu (p<0,05). Sonuç: Açıklanamayan infertilite olgularında endometriyal dokuda ürokortin ekspresyonunun düşük saptanması, implantasyon sürecinde rol oynayan lokal inflamatuar yanıtın yetersiz olabileceğini düşündürmektedir.

🔖

Cite This Article

Çağıran, F. T., Çiçek, S., Kalı, Z., Kırıcı, P., Çılgın, H. (2026). Investigation of urocortin expression in endometrial tissue in women with unexplained infertility. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 12 Sayı: 1, 101–107. https://doi.org/10.30569/adiyamansaglik.1871643

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (26)

  1. Kamath MS, Bhattacharya S. Demographics of infertility and management of unexplained infertility. Best Pract Res Clin Obstet Gynaecol. 2012;26(6):729–738.
  2. Novembri R, Carrarelli P, Toti P, Rocha AL, Borges LE, Reis FM, et al. Urocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response. Mol Hum Reprod. 2011;17(9):587–593.
  3. Florio P, Arcuri F, Ciarmela P, Runci Y, Romagnoli R, Cintorino M, et al. Identification of urocortin mRNA and peptide in the human endometrium. J Endocrinol. 2002;173(2):R9–R14.
  4. Torricelli M, De Falco G, Florio P, Rossi M, Leucci E, Viganò P, et al. Secretory endometrium highly expresses urocortin messenger RNA and peptide: possible role in the decidualization process. Hum Reprod. 2007;22(1):92–96.
  5. Liang Y, Han J, Jia C, Ma Y, Lan Y, Li Y, et al. Effect of endometrial injury on secretion of endometrial cytokines and IVF outcomes in women with unexplained subfertility. Mediators Inflamm. 2015;2015:757184.
  6. Guo F, Si C, Zhou M, Wang J, Zhang D, Leung PCK, et al. Decreased PECAM1-mediated TGF-β1 expression in the mid-secretory endometrium in women with recurrent implantation failure. Hum Reprod. 2018;33(5):832–843.
  7. Schlitzer A, McGovern N, Ginhoux F. Dendritic cells and monocyte-derived cells: two complementary and integrated functional systems. Semin Cell Dev Biol. 2015;41:9–22.
  8. Gnainsky Y, Granot I, Aldo P, Barash A, Or Y, Mor G, et al. Biopsy-induced inflammatory conditions improve endometrial receptivity: the mechanism of action. Reproduction. 2015;149(1):75–85.
  9. Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril. 2010;94(6):2030–2036.
  10. Dekel N, Gnainsky Y, Granot I, Racicot K, Mor G. The role of inflammation for a successful implantation. Am J Reprod Immunol. 2014;72(2):141–147.
  11. Siristatidis C, Vrachnis N, Vogiatzi P, Chrelias C, Retamar AQ, Bettocchi S, et al. Potential pathophysiological mechanisms of the beneficial role of endometrial injury in in vitro fertilization outcome. Reprod Sci. 2014;21(8):955–965.
  12. Petraglia F, Imperatore A, Challis JR. Neuroendocrine mechanisms in pregnancy and parturition. Endocr Rev. 2010;31(6):783–816.
  13. Carrarelli P, Luddi A, Funghi L, Arcuri F, Batteux F, Dela Cruz C, et al. Urocortin and corticotrophin-releasing hormone receptor type 2 mRNA are highly expressed in deep infiltrating endometriotic lesions. Reprod Biomed Online. 2016;33(4):476–483.
  14. Elnaggar A, Farag AH, Gaber ME, Hafeez MA, Ali MS, Atef AM. AlphaVβ3 integrin expression within uterine endometrium in unexplained infertility: a prospective cohort study. BMC Womens Health. 2017;17(1):90.
  15. Gunn DD, Bates GW. Evidence-based approach to unexplained infertility: a systematic review. Fertil Steril. 2016;105(6):1566–1574.e1.
  16. Muramatsu Y, Fukushima K, Iino K, Totsune K, Takahashi K, Suzuki T, et al. Urocortin and corticotropin-releasing factor receptor expression in the human colonic mucosa. Peptides. 2000;21:1799–1809.
  17. Slominski A, Wortsman J, Pisarchik A, Zbytek B, Linton EA, Mazurkiewicz JE, et al. Cutaneous expression of corticotropin-releasing hormone (CRH), urocortin, and CRH receptors. FASEB J. 2001;15(10):1678–1693.
  18. Wu Y, Zhou H, Xu Y, Li S. Enhanced expression of urocortin in lung tissues of rats with allergic asthma. Biochem Biophys Res Commun. 2006;341(2):532–540.
  19. Kohno M, Kawahito Y, Tsubouchi Y, Hashiramoto A, Yamada R, Inoue KI, et al. Urocortin expression in synovium of patients with rheumatoid arthritis and osteoarthritis: relation to inflammatory activity. J Clin Endocrinol Metab. 2001;86(9):4344–4352.
  20. Huang M, Kempuraj D, Papadopoulou N, Kourelis T, Donelan J, Manola A, et al. Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK, and NF-κB activation. J Mol Endocrinol. 2009;42(5):397–405.
  21. Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol. 2010;63(1):17–21.
  22. Zhou L, Li R, Wang R, Huang HX, Zhong K. Local injury to the endometrium in controlled ovarian hyperstimulation cycles improves implantation rates. Fertil Steril. 2008;89(5):1166–1176.
  23. Goel T, Mahey R, Bhatla N, Kalaivani M, Pant S, Kriplani A. Pregnancy after endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination cycles: a randomized controlled trial. J Assist Reprod Genet. 2017;34(8):1051–1058.
  24. Maged AM, Al-Inany H, Salama KM, Souidan II, Abo Ragab HM, Elnassery N. Endometrial scratch injury induces higher pregnancy rate for women with unexplained infertility undergoing IUI with ovarian stimulation: a randomized controlled trial. Reprod Sci. 2016;23(2):239–243.
  25. Lédée N, Petitbarat M, Prat-Ellenberg L, et al. The next frontier in ART: Harnessing the uterine immune profile for improved performance. Int J Mol Sci. 2023;24(14):11322. Published 2023 Jul 11. doi:10.3390/ijms241411322
  26. Robertson SA, Moldenhauer LM, Green ES, Care AS, Hull ML. Immune determinants of endometrial receptivity: a biological perspective. Fertil Steril. 2022;117(6):1107-1120. doi:10.1016/j.fertnstert.2022.04.023