SavedAdd your journal

Journals / Adıyaman Üniversitesi Sağlık Bilimleri Dergisi / 2026 / Cilt: 12 Sayı: 2

Maternal serum copeptin levels in threatened preterm labor as a potential predictor of preterm birth

Maternal serum kopeptin düzeylerinin erken doğum tehdidinde preterm doğumu öngörmedeki potansiyel rolü

Sevil Çiçek(İSTANBUL MEDENİYET ÜNİVERSİTESİ)0000-0001-6147-8102
Fatma Tanılır Çağıran0000-0002-1460-6965
Zercan Kalı0000-0002-7128-7550
Hasan Çılgın0000-0002-7279-5995
Pages
169–175
Publication Date
2026-08-20
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

AUC was 0.88 in the threatened preterm labor group and 0.94 overall.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To evaluate maternal serum copeptin levels and their predictive value for preterm birth in women with threatened preterm labor.
📊
Key Findings & Data:Materials and Methods: This prospective study included 100 pregnant women (50 with threatened preterm labor, 50 controls) between 28–34 weeks.
💡
Conclusion & Impact:AUC was 0.88 in the threatened preterm labor group and 0.94 overall.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Kopeptin · Preterm doğum · Erken doğum tehdidi

Abstract

Aim: To evaluate maternal serum copeptin levels and their predictive value for preterm birth in women with threatened preterm labor. Materials and Methods: This prospective study included 100 pregnant women (50 with threatened preterm labor, 50 controls) between 28–34 weeks. The threatened preterm labor group was subdivided into term (n=28) and preterm (n=22) deliveries. Copeptin levels were measured by enzyme immunoassay and analyzed using ROC curves. Results: Copeptin levels were significantly higher in women who delivered preterm (1.82±0.29 ng/mL) compared to term (1.22±0.40 ng/mL) and controls (0.97±0.34 ng/mL) (p<0.001). AUC was 0.88 in the threatened preterm labor group and 0.94 overall. At a cutoff of 1.33 ng/mL, sensitivity was 100% and specificity 64.3%. Conclusion: Maternal copeptin levels are elevated in women with threatened preterm labor who deliver preterm. Copeptin may represent a potential adjunctive biomarker for predicting preterm birth.

Özet

Amaç: Bu çalışmada, erken doğum tehdidi ile başvuran gebelerde maternal serum kopeptin düzeylerinin değerlendirilmesi ve preterm doğumu öngörmedeki değerinin araştırılması amaçlandı. Gereç ve Yöntem: Bu prospektif çalışmaya 28–34 gebelik haftaları arasında 100 gebe (50 erken doğum tehdidi, 50 kontrol) dahil edildi. Erken doğum tehdidi grubu term (n=28) ve preterm (n=22) doğum yapanlar olarak ikiye ayrıldı. Kopeptin düzeyleri enzim immünoassay yöntemi ile ölçüldü ve ROC analizi ile değerlendirildi. Bulgular: Preterm doğum yapanlarda kopeptin düzeyleri (1,82±0,29 ng/mL), term doğum yapanlar (1,22±0,40 ng/mL) ve kontrol grubuna (0,97±0,34 ng/mL) göre anlamlı derecede yüksekti (p<0,001). AUC değeri erken doğum tehdidi grubunda 0,88, tüm popülasyonda 0,94 bulundu. 1,33 ng/mL kesim değerinde duyarlılık %100, özgüllük %64,3 idi. Sonuç: Erken doğum tehdidi olan ve preterm doğum yapan gebelerde kopeptin düzeyleri yüksektir. Kopeptin, preterm doğumun öngörülmesinde yardımcı bir biyobelirteç olabilir.

🔖

Cite This Article

Çiçek, S., Çağıran, F. T., Kalı, Z., Çılgın, H. (2026). Maternal serum copeptin levels in threatened preterm labor as a potential predictor of preterm birth. Adıyaman Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 12 Sayı: 2, 169–175. https://doi.org/10.30569/adiyamansaglik.1912538

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Ohuma EO, Moller AB, Bradley E, Chakwera S, Hussain-Alkhateeb L, Lewin A, et al. National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis. Lancet. 2023;402(10409):1261-1271.
  2. Karaduman, A. B., Balcı, M. F., Özizmirliler, E. C. U., Özağaç, B., Şanlı, M., Kıncı, M. F., & Akpak, Y. K. (2024). Evaluation of the use of first and third-trimester hemogram parameters in prediction of preterm labor. Perinatal J, 32(3), 239-245.
  3. Di Renzo GC, Cabero Roura L, Facchinetti F, Helmer H, Hubinont C, Jacobsson B, et al. Preterm labor and birth management: recommendations from the European Association of Perinatal Medicine. J Matern Fetal Neonatal Med. 2017;30(17):2011-2030.
  4. Boots AB, Sanchez-Ramos L, Bowers D, Kaunitz AM, Zamora J. The short-term prediction of preterm birth: a systematic review and diagnostic meta-analysis. Am J Obstet Gynecol. 2014;210(1):54.e1-54.e10.
  5. Sinning C, Kempf T, Schwarzl M, Lanfermann S, Ojeda F, Schnabel RB, et al. Biomarkers for characterization of patients with cardiovascular disease: a focus on copeptin. Clin Chem Lab Med. 2017;55(3):346-357.
  6. Nickel CH, Bingisser R, Morgenthaler NG. The role of copeptin as a biomarker in clinical medicine. J Intern Med. 2021;290(1):1-15.
  7. Santillan DA, Santillan MK, Saftlas AF, Hunter SK, Leslie KK. Serum copeptin levels in early pregnancy predict the subsequent development of preeclampsia. Hypertension. 2014;64(6):1362-1367.
  8. Yeung EH, Liu A, Mills JL, et al. Increased levels of copeptin before clinical diagnosis of preeclampsia. Hypertension. 2014;64(6):1362-1367. doi:10.1161/HYPERTENSIONAHA.114.03762.
  9. Tuten A, Oncul M, Kucur M, Imamoglu M, Acikgoz AS, Madazli R. Serum copeptin levels in gestational diabetes mellitus and their relationship with pregnancy outcomes. J Obstet Gynaecol Res. 2022;48(3):655-662.
  10. Martino M, Arnaldi G. Copeptin and Stress. Endocrines. 2021; 2(4):384-404. https://doi.org/10.3390/endocrines2040035
  11. Tulmac OB, Aydin S, Yucel N, et al. Maternal serum copeptin levels in threatened preterm labor. J Matern Fetal Neonatal Med. 2016;29(10):1602-1606.
  12. Foda AA, Abdel Aal DM. Evaluation of maternal serum copeptin levels in preterm labor. J Obstet Gynaecol Res. 2019;45(8):1498-1504.
  13. Dobsa L, Edozien KC. Copeptin and its potential role in diagnosis and prognosis of various diseases. Biochem Med (Zagreb). 2013;23(2):172-190. doi:10.11613/bm.2013.021
  14. Katan, M., & Christ-Crain, M. (2010). The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss medical weekly, 140, w13101. https://doi.org/10.4414/smw.2010.13101