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Journals / Çukurova Anestezi ve Cerrahi Bilimler Dergisi / 2026 / Cilt: 9 Sayı: 3

Predictive Value of Systemic Immune-Inflammation Index for Infectious Complications Following Transrectal Ultrasound-Guided Prostate Biopsy

Transrektal Ultrason Eşliğinde Prostat Biyopsisi Sonrası Enfeksiyöz Komplikasyonların Öngörülmesinde Sistemik İmmün-İnflamasyon İndeksinin Prediktif Değeri

Ahmet Emin Doğan(Ankara Etlik City Hospital)0000-0002-0670-3044
Muhammed Yusuf Aydın0009-0002-6149-6970
Kadri Sergen Akca(Ankara Etlik City Hospital)0009-0003-9134-4991
Mehmet Altan(Sağlık Bakanlığı Etimesgut Şehit Sait Ertürk Devlet Hastanesi)0000-0002-0504-3988
Görkem Özenç(Ankara Etlik City Hospital)0000-0001-8853-5250
Arif Huseynli(Ankara Etlik City Hospital)0000-0001-8197-9799
Pages
799–806
Publication Date
2026-09-30
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Keywords: Biomarkers; Biopsy; Inflammation; Prostate; Sepsis.

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract: Aim: This study aimed to evaluate the predictive value of the systemic immune-inflammation index (SII) for infectious complications following transrectal ultrasound-guided prostate biopsy.
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Key Findings & Data:Materials and Methods: This retrospective study included 342 patients who underwent transrectal ultrasound-guided prostate biopsy.
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Conclusion & Impact:Keywords: Biomarkers; Biopsy; Inflammation; Prostate; Sepsis.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Biyobelirteçler · Biyopsi · İnflamasyon

Abstract

Abstract: Aim: This study aimed to evaluate the predictive value of the systemic immune-inflammation index (SII) for infectious complications following transrectal ultrasound-guided prostate biopsy. Materials and Methods: This retrospective study included 342 patients who underwent transrectal ultrasound-guided prostate biopsy. Inflammatory indices were calculated prior to biopsy using complete blood count parameters. In addition to the systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were also evaluated. Inflammatory indices were compared between patients with and without post-biopsy infection using nonparametric statistical tests. Receiver operating characteristic (ROC) curve analysis was applied to evaluate predictive performance. Results: Post-biopsy infection occurred in 33 patients (9.6%). No statistically significant differences were observed in SII, NLR, PLR, or MLR values between patients with and without post-biopsy infection (all p > 0.05). While SII values showed a tendency to be higher in the group of patients experiencing post-biopsy infection, these differences were not statistically significant (p = 0.069). ROC analysis revealed poor discriminatory performance for all inflammatory indices; with area under the curve values were 0.596 for SII, 0.585 for NLR, 0.558 for PLR, and 0.522 for MLR. Conclusion: Pre-biopsy inflammatory indices demonstrated limited predictive performance for post-biopsy infectious complications. Future prospective multicenter studies integrating inflammatory, clinical, and microbiological parameters are needed. Keywords: Biomarkers; Biopsy; Inflammation; Prostate; Sepsis. Word count: 217

Özet

Özet: Amaç: Bu çalışma, transrektal ultrason eşliğinde prostat biyopsisi sonrası enfeksiyon komplikasyonları için sistemik immün-inflamasyon indeksinin (SII) öngörücü değerini değerlendirmeyi amaçlamıştır. Materyaller ve Yöntemler: Bu retrospektif çalışmaya, transrektal ultrason eşliğinde prostat biyopsisi geçiren 342 hasta dahil edilmiştir. Biyopsiden önce, tam kan sayımı parametreleri kullanılarak inflamasyon indeksleri hesaplanmıştır. Sistemik immün-inflamasyon indeksine (SII) ek olarak, nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR) ve monosit-lenfosit oranı (MLR) da değerlendirilmiştir. İnflamatuvar indeksler, biyopsi sonrası enfeksiyonu olan ve olmayan hastalar arasında parametrik olmayan istatistiksel testler kullanılarak karşılaştırılmıştır. Öngörücü performansı değerlendirmek için alıcı işletim karakteristik (ROC) eğrisi analizi uygulanmıştır. Sonuçlar: Biyopsi sonrası enfeksiyon 33 hastada (%9,6) meydana gelmiştir. Biyopsi sonrası enfeksiyonu olan ve olmayan hastalar arasında SII, NLR, PLR veya MLR değerlerinde istatistiksel olarak anlamlı bir fark gözlenmedi (tüm p > 0,05). SII değerleri, biyopsi sonrası enfeksiyon geçiren hasta grubunda daha yüksek olma eğilimi gösterse de, bu farklar istatistiksel olarak anlamlı değildi (p = 0,069). ROC analizi, tüm inflamatuar indeksler için zayıf ayırt edici performans ortaya koydu; eğri altındaki alan değerleri SII için 0,596, NLR için 0,585, PLR için 0,558 ve MLR için 0,522 idi. Sonuç: 213 Biyopsi öncesi inflamatuar indeksler, biyopsi sonrası enfeksiyon komplikasyonları için sınırlı tahmin performansı göstermiştir. İnflamatuvar, klinik ve mikrobiyolojik parametreleri entegre eden gelecekteki prospektif çok merkezli çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Biyobelirteçler; Biyopsi; İnflamasyon; Prostat; Sepsis. Kelime sayısı:

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Cite This Article

Doğan, A. E., Aydın, M. Y., Akca, K. S., Altan, M., Özenç, G., Huseynli, A. (2026). Predictive Value of Systemic Immune-Inflammation Index for Infectious Complications Following Transrectal Ultrasound-Guided Prostate Biopsy. Çukurova Anestezi ve Cerrahi Bilimler Dergisi, Cilt: 9 Sayı: 3, 799–806. https://doi.org/10.36516/jocass.1960814

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