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Journals / Anatolian Journal of Emergency Medicine / 2026 / Cilt: 7 Sayı: 2

Impact of Erythrocyte Transfusion on Thiol/Disulfide Homeostasis in Anemic Patients

Eritrosit Transfüzyonunun Anemik Hastalarda Tiyol/Disülfit Homeostazı Üzerine Etkisi

Selçuk Coşkun(UNIVERSITY OF HEALTH SCIENCES, ANKARA HEALTH RESEARCH CENTER)0000-0001-6745-446X
Ferhat İçme(UNIVERSITY OF HEALTH SCIENCES, ANKARA HEALTH RESEARCH CENTER)0000-0001-5180-7152
Yücel Yüzbaşıoğlu(UNIVERSITY OF HEALTH SCIENCES, GÜLHANE FACULTY OF HEALTH SCIENCES)0000-0002-4622-2456
Fatih Tanrıverdi(ANKARA YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF EMERGENCY MEDICINE)0000-0001-9959-5769
Gül Pamukçu Günaydın(ANKARA YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF EMERGENCY MEDICINE)0000-0001-8531-4591
Cagri Serdar Elgormus(UNIVERSITY OF HEALTH SCIENCES, ANKARA HEALTH RESEARCH CENTER)0000-0001-9412-6568
Özcan Erel(ANKARA YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES (MEDICINE), DEPARTMENT OF MEDICAL BIOCHEMISTRY (MEDICINE))0000-0002-2996-3236
Salim Neşelioğlu(ANKARA YILDIRIM BEYAZIT UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES (MEDICINE), DEPARTMENT OF MEDICAL BIOCHEMISTRY (MEDICINE))0000-0002-0974-5717
Pages
63–66
Publication Date
2024-06-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our findings suggest a potential increase in overall oxidative stress.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Anemia limits oxygen delivery to tissues, potentially leading to increased oxidative stress.
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Key Findings & Data:Results: The concentrations of total thiol (374.24±94.84 to 344.6±88.5) and native thiol (338.91±90.51 to 304.91±90.95) significantly decreased after erythrocyte suspension treatment compared to baseline (P<0.0001).
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Conclusion & Impact:Our findings suggest a potential increase in overall oxidative stress.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Anemi · disulfide · eritrosit transfüzyonu

Abstract

Aim: Anemia limits oxygen delivery to tissues, potentially leading to increased oxidative stress. This study examined the impact of erythrocyte transfusion on thiol/disulfide homeostasis, a marker of oxidative stress, in anemic patients. Material and Methods: Sixty anemic patients receiving transfusions in emergency department were included in this study. We measured total thiol, native thiol, and disulfide levels in blood samples collected before and after red blood cell transfusion. To isolate the effects of anemia, a subgroup analysis that excluded patients with acute/subacute hemorrhage or aplastic anemia was also done. Results: The concentrations of total thiol (374.24±94.84 to 344.6±88.5) and native thiol (338.91±90.51 to 304.91±90.95) significantly decreased after erythrocyte suspension treatment compared to baseline (P<0.0001). However, the disulfide level increased (17.75±6.63 to 20.97±7.25; p = 0.009). Our findings suggest a potential increase in overall oxidative stress. Conclusion: By giving transfusions to anemic patients one may think that oxidative stress will be reduced due to increased oxygen carrying capacity but our results show the contrary. Our results support that oxidative stress increases in vivo in patients who receive transfusion right after the procedure and this is probably due to increased oxidative stressin stored erythrocyte suspensions.

Özet

Amaç: Anemi, dokulara oksijen taşınmasını kısıtlar, bu da potansiyel olarak artmış oksidatif stres ile sonuçlanabilir. Bu çalışmada, anemik hastalarda eritrosit transfüzyonunun oksidatif stresin bir göstergesi olan tiyol/disülfit homeostazı üzerindeki etkisinin incelenmesi amaçlandı. Gereç ve Yöntemler: Çalışmaya acil serviste transfüzyon alan altmış anemik hasta dahil edildi. Eritrosit transfüzyonu öncesi ve sonrası toplanan kan örneklerinde toplam tiyol, nativ tiyol ve disülfid seviyeleri ölçüldü. Aneminin etkilerini izole etmek için, akut/subakut kanama veya aplastik anemi olan hastalar hariç tutularak alt grup analizi de yapıldı. Bulgular: Total tiyol (374.24±94.84'ten 344.6±88.5'e) ve nativ tiyol (338.91±90.51'den 304.91±90.95'e) konsantrasyonları, eritrosit süspansiyonu transfüzyonu sonrası başlangıca göre anlamlı olarak azaldı (P<0.0001). Ancak, disülfid seviyesi arttı (17.75±6.63'ten 20.97±7.25'e; p = 0.009). Bulgularımız hastalarda oksidatif stresin transfüzyon sonrası arttığını göstermektedir. Sonuç: Anemik hastalara eritrosit transfüzyonu yapıldığında oksidatif stresin azalacağı düşünülebilir çünkü transfüzyonla oksijen taşıma kapasitesi artar, ancak sonuçlarımız bunun aksini göstermektedir. Sonuçlarımız, transfüzyon alan hastalarda işlemden hemen sonra oksidatif stresin arttığını göstermektedir. Bu durum muhtemelen depolanan eritrosit süspansiyonlarında artan oksidatif stresle ilgili olabilir.

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Cite This Article

Coşkun, S., İçme, F., Yüzbaşıoğlu, Y., Tanrıverdi, F., Günaydın, G. P., Elgormus, C. S., Erel, Ö., Neşelioğlu, S. (2024). Impact of Erythrocyte Transfusion on Thiol/Disulfide Homeostasis in Anemic Patients. Anatolian Journal of Emergency Medicine, Cilt: 7 Sayı: 2, 63–66. https://doi.org/10.54996/anatolianjem.1468418

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