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Journals / Akdeniz Tıp Dergisi / 2026 / Cilt: 11 Sayı: 2

The Role of Vitamin D Supplementation Program on Fertility Outcomes in Women with Embryo Transfers

Embriyo Transferi Yapılan Kadınlarda D Vitamini Destek Programının Doğurganlık Sonuçları Üzerindeki Rolü

Gamze Yavaş(Kumluca Sağlık Bilimleri Fakültesi)0000-0003-0298-9716
Murat Özekinci(AKDENIZ UNIVERSITY)0000-0001-7937-0335
İlkay Boz(AKDENIZ UNIVERSITY)0000-0002-3529-9351
Mehmet Sakıncı0000-0001-5074-0005
Pages
164–171
Publication Date
2025-05-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: This study demonstrated that vitamin D supplementation program for women undergoing infertility treatment with deficient or insufficient vitamin D levels may increase vitamin D levels and clinical pregnancy rate after embryo transfer.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to determine the effect of vitamin D supplementation given to women undergoing embryo transfer on pregnancy outcomes.
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Key Findings & Data:The sample of the study consisted of a total of 118 women, with 58 in the intervention group and 60 in the control group.
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Conclusion & Impact:Conclusion: This study demonstrated that vitamin D supplementation program for women undergoing infertility treatment with deficient or insufficient vitamin D levels may increase vitamin D levels and clinical pregnancy rate after embryo transfer.
🔬Design:Klinik Araştırma
📍Scope:Comprehensive Sample
⚙️Variables:Embriyo Transferi · infertilite · gebelik oranı

Abstract

Objective: This study aimed to determine the effect of vitamin D supplementation given to women undergoing embryo transfer on pregnancy outcomes. Materials and Methods: This study was conducted experimentally in a pre-test-post-test design. The sample of the study consisted of a total of 118 women, with 58 in the intervention group and 60 in the control group. While the vitamin D supplementation program was administered to women in the intervention group at the beginning of infertility treatment, women in the control group did not receive a vitamin D supplementation program. At the end of the study, pregnancy and clinical pregnancy rates of women in the intervention and control groups, as well as their serum 25(OH) D levels, were examined. Results: The vitamin D level of women in the intervention group at the beginning of treatment (12.47±6.03 ng/mL) was statistically significantly lower than the vitamin D level on the day of beta-hCG (32.34±9.62 ng/mL) (p=0.000). The mean vitamin D level of the women in the control group (14.30±7.03 ng/mL) on the day of beta-hCG was statistically significantly lower than that of the women in the intervention group (32.34±9.62 ng/mL) (p=0.000). While there was no statistically significant difference in the pregnancy rates of women in the intervention and control groups, a statistically significant difference was found in the clinical pregnancy rates (respectively, p=0.066 and p=0.014). Conclusion: This study demonstrated that vitamin D supplementation program for women undergoing infertility treatment with deficient or insufficient vitamin D levels may increase vitamin D levels and clinical pregnancy rate after embryo transfer.

Özet

Amaç: Bu çalışma embriyo transferi yapılan kadınlara verilen D vitamini desteğinin, gebelik sonuçları üzerindeki etkisini belirlemeyi amaçlamaktadır. Gereç ve Yöntemler: Bu çalışma ön test-son test düzeninde deneysel olarak yürütülmüştür. Çalışmanın örneklemi 58’i girişim, 60’ı kontrol grubunda olmak üzere toplam 118 kadından oluşmaktadır. Girişim grubundaki kadınlara infertilite tedavisinin başlangıcında D vitamini destek programı uygulanırken, kontrol grubundaki kadınlara D vitamini destek programı uygulanmamıştır. Çalışmanın sonunda, girişim ve kontrol grubundaki kadınların gebelik ve klinik gebelik oranları ve kanda 25(OH)D düzeyleri incelenmiştir. Bulgular: Girişim grubundaki kadınların tedavi başlangıcındaki D vitamini düzeyi (12,47±6,03 ng/mL), beta-hCG günü bakılan D vitamin düzeyinden (32,34±9,62 ng/mL) istatistiksel olarak anlamlı düzeyde daha düşüktür (p=0,000). Kontrol grubundaki kadınların beta-hCG günü bakılan D vitamini düzeyi (14,30±7,03 ng/mL), girişim grubundaki kadınlardan (32,34±9,62 ng/mL) istatistiksel olarak anlamlı derecede daha düşüktür (p=0,000). Girişim ve kontrol grubundaki kadınların gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmazken, klinik gebelik oranlarında istatistiksel olarak anlamlı bir fark bulunmuştur (p=0,066, p=0,014 sırasıyla). Sonuç: Bu çalışma, infertilite tedavisi gören ve D vitamini düzeyi eksik ya da yetersiz olan kadınlara yönelik D vitamini destek programının, kadınların D vitamini düzeylerini ve embriyo transferi sonrası klinik gebelik oranlarını artırabileceğini göstermiştir.

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Cite This Article

Yavaş, G., Özekinci, M., Boz, İ., Sakıncı, M. (2025). The Role of Vitamin D Supplementation Program on Fertility Outcomes in Women with Embryo Transfers. Akdeniz Tıp Dergisi, Cilt: 11 Sayı: 2, 164–171. https://doi.org/10.53394/akd.1390776

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References (31)

  1. Down J, Stafford D. The Vitamin D cure revised edition. Canada: John Wiley & Sons; 2012.
  2. Lauretani F, Maggio M, Ruggiero C, Ceda GP, Ferrucci L. Vitamin D in health of seniors. In: Watson RR, editors. Handbook of Vitamin D in human health. Netherlands: Wageningen Academic Publishers; 2013.
  3. Grzechocinska B, Dabrowski FA, Cyganek A, Wielgos M. The role of vitamin D in impaired fertility treatment. Neuro Endocrinol Lett 2013; 34(8):756-62.
  4. De-Regil LM, Palacios C, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev 2016; 1(1):CD008873.
  5. Ferrero S, Gillott DJ, Anserini P, Remorgida V, Price KM, Ragni N, Grudzinskas JG. Vitamin D binding protein in endometriosis. Soc Gynecol Investig 2005; 12(4):272-77.
  6. Somigliana E, Panina-Bordignon P, Murone S, Di Lucia P, Vercellini P, Vigano P. Vitamin D reserve is higher in women with endometriosis. Hum Reprod 2007; 22(8):2273-78.
  7. Harris HR, Chavarro JE, Malspeis S, Willett WC, Missmer SA. Dairy-food, calcium, magnesium, and vitamin D intake and endometriosis: a prospective cohort study. Am J Epidemiol 2013; 177(5):420-30.
  8. Pagliardini L, Vigano' P, Molgora M, Persico P, Salonia A, Vailati SH, Paffoni A, Somigliana E, Papaleo E, Candiani M. High prevalence of vitamin D deficiency in infertile women referring for assisted reproduction. Nutrients 2015; 7(12):9972-84.
  9. Sur D, Chakravorty R. The relationship between Vitamin D, insülin resistance and infertility in PCOS women. Gynecol Obstet 2015; 5(5):1-4.
  10. Wehr E, Pieber TR, Obermayer-Pietsch B. Effect of vitamin D3 treatment on glucose metabolism and menstrual frequency in polycystic ovary syndrome women: a pilot study. J Endocrinol Invest 2011; 34:757-63.
  11. Thomson RL, Spedding S, Buckley JD. Vitamin D in the etiology and management of polycystic ovary syndrome. Clin Endocrinol 2012; 77(3):343-50.
  12. Asadi M, Matin N, Frootan M, Mohamadpour J, Qorbani M, Tanha FD. Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized double-blind placebo. Arch Gynecol Obstet 2014; 289(4):865-70.
  13. Baird DD, Hill MC, Schectman JM, Hollis BW. Vitamin D and the risk of uterine fibroids. Epidemiology 2013; 24:447-53.
  14. Paffoni A, Somigliana E, Vigano' P, Benaglia L, Cardellicchio L, Pagliardini L, Papaleo E, Candiani M, Fedele L. Vitamin D status in women with uterine leiomyomas. J Clin Endocrinol Metab 2013; 98(8):E1374-E78.
  15. Sabry M, Halder SK, Allah AS, Roshdy E, Rajaratnam V, Al-Hendy A. Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: a cross-sectional observational study. Int J Womens Health 2013; 5:93-100.
  16. Özkaya F, Demirel A. Vitamin D deficiency in infertile patients. Arch Esp Urol 2018; 71(10):850-5.
  17. Triggianese P, Watad A, Cedola F, Perricone C, Amital H, Giambini I, Perricone R, Shoenfeld Y, De Carolis C. Vitamin D deficiency in an Italian cohort of infertile women. Am J Reprod Immunol 2017; 78(4):1-6.
  18. Li L, Schriock E, Dougall K, Givens C. Prevalence and risk factors of vitamin D deficiency in women with infertility. Fertil Steril 2012; 97(3): S26.
  19. Vanni VS, Vigano' P, Somigliana E, Papaleo E, Paffoni A, Pagliardini L, Candiani M. Vitamin D and assisted reproduction technologies: current concepts. Reprod Biol Endocrinol 2014; 12: 47.
  20. Boz İ, Teskereci G, Özekinci M. High prevalence of vitamin D deficiency in Turkish women undergoing in vitro fertilization: A descriptive study. Health Care Women Int 2019; 29:1-12.
  21. Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod 2012; 27(11):3321-27.
  22. Garbedian K, Boggild M, Moody J, Liu KE. Effect of vitamin D status on clinical pregnancy rates following in vitro fertilization. CMAJ Open 2013; 28(1):77-82.
  23. Paffoni A, Ferrari S, Viganò P, Pagliardini L, Papaleo E, Candiani M, Tirelli A, Fedele L, Somigliana E. Vitamin D deficiency and infertility: Insights from in vitro fertilization cycles. J Clin Endocrinol Metab 2014; 99(11):E2372-E76.
  24. Polyzos NP, Anckaert E, Guzman L, Schiettecatte J, Van Landuyt L, Camus M, Smitz J, Tournaye H. Vitamin D deficiency and pregnancy rates in women undergoing single embryo, blastocyst stage, transfer (SET) for IVF/ ICSI. Hum Reprod 2014; 29(9):2032-40.
  25. Aflatoonian A, Arabjahvani F, Eftekhar M, Sayadi M. Effect of vitamin D insufficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles: a randomized clinical trial. Iran J Reprod Med 2014; 12(9):595-600.
  26. Fabris A, Pacheco A, Cruz M, Puente JM, Fatemi H, Garcia-Velasco JA. Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients. Fertil Steril 2014; 102(6):1608-12.
  27. Franasiak JM, Molinaro TA, Dubell EK, Scott KL, Ruiz AR, Forman EJ, Werner MD, Hong KH, Scott RT Jr. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol 2015; 212(3):315.e1-6.
  28. Fatemi F, Mohammadzadeh A, Sadeghi MR, Akhondi MM, Mohammadmoradi S, Kamali K, Lackpour N, Jouhari S, Zafadoust S, Mokhtar S, Giahi L. Role of vitamin E and D3 supplementation in Intra-Cytoplasmic Sperm Injection outcomes of women with polycystic ovarian syndrome: a double-blinded randomized placebo-controlled trial. Clin Nutr ESPEN 2017; 18:23-30.
  29. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96(7):1911-30.
  30. Naderi Z, Kashanian M, Chenari L, Sheikhansari N. Evaluating the effects of administration of 25-hydroxyvitamin D supplement on serum antimullerian hormone (AMH) levels in infertile women. Gynecol Endocrinol 2018; 34(5):409-12.
  31. Lerchbaum E, Obermayer-Pietsch B. Vitamin D, and fertility: a systematic review. Eur J Endocrinol 2012; 166(5):765-78.