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Journals / Akdeniz Tıp Dergisi / 2025 / Cilt: 11 Sayı: 3

The Therapeutic Efficacy of Gentisic Acid in Torsion-Detorsion Model of Ovarian Tissue in Rats

Ayhan Tanyeli(Atatürk Üniversitesi)0000-0002-0095-0917
Mustafa Can Güler(ATATÜRK ÜNİVERSİTESİ)0000-0001-8588-1035
Fazile Nur Ekinci Akdemir(Sağlık Bilimleri Üniversitesi Erzurum Tıp Fakültesi Fizyoloji Anabilim Dalı)0000-0001-9585-3169
Ersen Eraslan(BANDIRMA ONYEDİ EYLÜL ÜNİVERSİTESİ)0000-0003-2424-2269
Emsal Pınar Topdağı Yılmaz(Atatürk Üniversitesi)0000-0001-8593-5726
Pages
324–330
Publication Date
2025-09-29
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Current data showed that ovarian damage caused by TD can be alleviated with low and high dose gentisic acid treatments.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study aimed to investigate the therapeutic effectiveness of gentisic acid in ovarian damage caused by torsion-detorsion.
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Key Findings & Data:Material and Methods: This research study was conducted using 32 female Wistar rats.
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Conclusion & Impact:Conclusion: Current data showed that ovarian damage caused by TD can be alleviated with low and high dose gentisic acid treatments.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Gentisik asit · torsiyon detorsiyon · yumurtalık dokusu

Abstract

Objective: This study aimed to investigate the therapeutic effectiveness of gentisic acid in ovarian damage caused by torsion-detorsion. Material and Methods: This research study was conducted using 32 female Wistar rats. All subjects were grouped into sham, torsion detorsion (TD), TD+Low dose and TD+High dose treatment groups in accordance with the experimental procedure. The TD model was created by clamping all of the arteries and collaterals feeding the ovary for 3 hours. Then, the clamp was opened and reperfusion was allowed for 3 hours. In TD+Low and TD+High dose treatment groups, gentisic acid was administered orally at doses of 100 and 200 mg/kg for 1 week, along with the TD model. Anesthesia conditions were created to ensure that the subjects did not feel any pain during all processes. Results: While the levels of oxidant parameters increased in the TD group compared to the Sham group, antioxidant levels were observed to decrease significantly in the TD+Low dose and TD+High dose groups. It was determined that while the levels of oxidant parameters decreased due to gentisic acid applications, antioxidant levels increased. Conclusion: Current data showed that ovarian damage caused by TD can be alleviated with low and high dose gentisic acid treatments.

Özet

Amaç: Bu çalışmada torsiyon detorsiyon aracılığıyla gerçekleşen over hasarında gentisik asit’in tedavi edici etkinliğinin araştırılması hedeflenmiştir. Gereç ve Yöntemler: Bu araştırma çalışması, 32 adet dişi Wistar sıçan kullanılarak yapıldı. Deney prosedürüne uygun olarak tüm denekler sham, torsiyon detorsiyon (TD), TD+Düşük doz ve TD+Yüksek doz tedavi grupları olacak biçimde gruplandırıldı. TD modeli overi besleyen arter ve kolleterallerin tamamı 3 saat klemplenerek oluşturuldu. Akabinde ise klemp açılarak 3 saat boyunca reperfüzyona izin verildi. TD+Düşük ve TD+Yüksek doz tedavi grupları TD modeli ile beraber 1 hafta süreyle 100 ve 200 mg/kg dozlarında gentisik asit oral yolla uygulandı. Tüm süreçlerde deneklerin acı duymaması için anestezi koşulları oluşturuldu. Bulgular: Sham grubuna göre TD grubunda oksidan parametrelerin düzeyleri yükselirken, antioksidan düzeylerinin ise TD+Düşük doz ve TD+Yüksek doz gruplarında anlamlı düzeyde azaldığı görüldü. Gentisik asit uygulamalarına bağlı olarak oksidan parametrelerin düzeyleri azalırken, antioksidan seviyelerinin arttığı belirlendi. Sonuç: Mevcut veriler TD'nin neden olduğu over hasarının düşük ve yüksek doz gentisik asit tedavileri ile hafifletilebileceğini gösterdi.

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Cite This Article

Tanyeli, A., Güler, M. C., Akdemir, F. N. E., Eraslan, E., Yılmaz, E. P. T. (2025). The Therapeutic Efficacy of Gentisic Acid in Torsion-Detorsion Model of Ovarian Tissue in Rats. Akdeniz Tıp Dergisi, Cilt: 11 Sayı: 3, 324–330. https://doi.org/10.53394/akd.1484971

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