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Journals / Akdeniz Tıp Dergisi / 2026 / Cilt: 12 Sayı: 1

Impact of Metabolic Syndrome on SVIP and p97/VCP Expression in Renal Tissue

Metabolik Sendromun Böbrek Dokusunda SVIP ve p97/VCP Ekspresyonu Üzerindeki Etkisi

Şeyma Kipel(ANKARA YILDIRIM BEYAZIT ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-4176-5136
Hilal Nakkaş(Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi)0000-0003-0901-8875
Ayça Bilginoğlu Topcu(Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi)0000-0002-1657-2607
Pages
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Publication Date
2026-09-22
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results represent a significant advancement in our knowledge of the causes and consequences of metabolic syndrome.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Metabolic syndrome (MetS) is a clinical condition in which a series of metabolic disorders occur together, increasing the risk of cardiovascular diseases and type 2 diabetes. p97/VCP is a member of the AAA+ ATPase protein family, which functions in various intracellular mechanisms.
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Key Findings & Data:It can bind to p97/VCP and suppress its role in processes such as ERAD.
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Conclusion & Impact:These results represent a significant advancement in our knowledge of the causes and consequences of metabolic syndrome.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Metabolik sendrom · böbrek · p97/VCP

Abstract

Objective: Metabolic syndrome (MetS) is a clinical condition in which a series of metabolic disorders occur together, increasing the risk of cardiovascular diseases and type 2 diabetes. p97/VCP is a member of the AAA+ ATPase protein family, which functions in various intracellular mechanisms. It plays a critical role, particularly in maintaining proteostasis and ERAD. SVIP is an adaptor protein found on the endoplasmic reticulum membrane. It can bind to p97/VCP and suppress its role in processes such as ERAD. MetS affects renal tissue through multifaceted mechanisms, increasing the risk of developing chronic kidney disease. This situation plays a key role in the development of diabetic nephropathy and hypertensive nephropathy in particular. Very little is known about the role of p97/VCP and SVIP in the MetS kidney. So, it is important to study p97/ VCP and SVIP in MetS kidney tissue. Material and Methods: Hematoxylin Eosin and Azan Trichrome stainings were used to examine the histomorphology of rat kidney tissue. The expression of p97/VCP and SVIP in tissue was investigated using immunohistochemistry. Results: Both the control and MetS kidney tissue showed signs of p97/VCP and SVIP expression. Comparing the two experimental groups, the MetS group showed higher SVIP expression and lower p97/VCP expression than the control group. Conclusion: Demonstrating the morphological alterations of the kidney in the control and MetS groups is crucial and histologically significant. Furthermore, SVIP and p97/VCP expressions in metabolic syndrome are significant for chronic renal disease. These results represent a significant advancement in our knowledge of the causes and consequences of metabolic syndrome.

Özet

Amaç: Metabolik sendrom (MetS), bir dizi metabolik bozukluğun bir arada ortaya çıktığı ve kardiyovasküler hastalıklar ile tip 2 diyabet riskini artırdığı klinik bir durumdur. p97/VCP, çeşitli hücre içi mekanizmalarda görev yapan AAA+ ATPaz protein ailesinin bir üyesidir. Özellikle proteostaz ve ERAD'ın sürdürülmesinde kritik bir rol oynar. SVIP, endoplazmik retikulum membranında bulunan bir adaptör proteindir. p97/VCP'ye bağlanarak ERAD gibi süreçlerdeki rolünü baskılayabilir. MetS, böbrek dokusunu çok yönlü mekanizmalarla etkileyerek kronik böbrek hastalığı geliştirme riskini artırır. Bu durum, özellikle diyabetik nefropati ve hipertansif nefropati gelişiminde kilit rol oynar. MetS böbreğinde p97/VCP ve SVIP'nin rolü hakkında çok az şey bilinmektedir. Bu nedenle, MetS böbrek dokusunda p97/VCP ve SVIP'nin incelenmesi önemlidir. Gereç ve Yöntemler: Sıçan böbrek dokusunun histomorfolojisini incelemek için Hematoksilen Eozin ve Azan Trikrom boyamaları kullanıldı. Dokudaki p97/VCP ve SVIP ekspresyonları immünohistokimya yaklaşımı kullanılarak araştırıldı. Bulgular: Hem kontrol hem de MetS böbrek dokusunda p97/VCP ve SVIP ekspresyonuna dair bulgular görüldü. İki deney grubu karşılaştırıldığında, MetS grubunun kontrol grubuna göre daha yüksek SVIP ekspresyonuna ve daha düşük p97/VCP ekspresyonuna sahip olduğu bulundu. Sonuç: Kontrol ve MetS gruplarında böbreğin morfolojik değişikliklerinin gösterilmesi çok önemli ve histolojik olarak anlamlıdır. Ayrıca, metabolik sendromdaki SVIP ve p97/VCP ekspresyonları kronik böbrek hastalığı açısından önemlidir. Bu sonuçlar, metabolik sendromun nedenleri ve sonuçları hakkındaki bilgimizde önemli bir ilerlemeyi temsil etmektedir.

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Cite This Article

Kipel, Ş., Nakkaş, H., Topcu, A. B. (2026). Impact of Metabolic Syndrome on SVIP and p97/VCP Expression in Renal Tissue. Akdeniz Tıp Dergisi, Cilt: 12 Sayı: 1. https://doi.org/10.53394/akd.1805762

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