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Journals / Akdeniz Tıp Dergisi / 2026 / Cilt: 12 Sayı: 1

Retrospective Evaluation of Acute Kidney Injury In Patients Treated with Nivolumab at Akdeniz University Faculty of Medicine Hospital

Akdeniz Üniversitesi Tıp Fakültesi Hastanesi’nde Nivolumab Tedavisi Uygulanmış Olan Hastalarda Akut Böbrek Hasarının Retrospektif Olarak Değerlendirilmesi

Üçler Can Ateş(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-3834-3976
Funda Sarı(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0128-3244
Pages
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Publication Date
2026-06-09
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

This study aims to contribute to the existing literature by presenting findings on the incidence, clinical characteristics, and potential risk factors of AKI occurring during treatment in cancer patients treated with nivolumab.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Immunotherapy is a treatment option that is being used more and more frequently in cancer treatment.
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Key Findings & Data:Results: The study included 143 patients.
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Conclusion & Impact:This study aims to contribute to the existing literature by presenting findings on the incidence, clinical characteristics, and potential risk factors of AKI occurring during treatment in cancer patients treated with nivolumab.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:İmmünoterapi · Nivolumab · Nefrotoksisite

Abstract

Objective: Immunotherapy is a treatment option that is being used more and more frequently in cancer treatment. This new treatment method strengthens the defense against malignancies by increasing immune system activation. However, this activation of the immune system may also lead to some immune side effects and toxicities. In this study, we aimed to retrospectively investigate the incidence, clinical characteristics, and potential risk factors of acute kidney injury (AKI) occurring during treatment in cancer patients treated with nivolumab, a type of immune checkpoint inhibitor (ICPI). Material and Methods: In this study, we evaluated the incidence, risk factors and clinical outcomes of acute kidney injury (AKI) in cancer patients treated with nivolumab. For this purpose, medical records of cancer patients treated with nivolumab were retrospectively reviewed. Duration of treatment, types of drugs used, changes in renal function, and development of extrarenal side effects were evaluated in patients with AKI. Results: The study included 143 patients. Of these patients, 116 were male and 27 were female. Twenty-three patients developed AKI. ICPI-related nephrotoxicity was not proven by performing a renal biopsy in any patient. Of the patients who developed AKI, 30,4% developed chronic kidney disease (CKD), 30,4% developed exitus, and 39,2% recovered. High baseline neutrophil/lymphocyte ratio and platelet/lymphocyte ratio and low baseline eosinophils were significantly associated with the development of AKI after nivolumab. The use of non-steroidal anti-inflammatory drugs (NSAID), proton pump inhibitors (PPI) or antibiotics during nivolumab treatment was not associated with the development of AKI. Extrarenal side effects, comorbid diseases and cancer type were not associated with the development of AKI. Conclusion: Although ICPIs play an important role in cancer treatment, they can also cause serious side effects such as nephrotoxicity. Therefore, close monitoring of renal function in patients treated with nivolumab is of great importance. This study aims to contribute to the existing literature by presenting findings on the incidence, clinical characteristics, and potential risk factors of AKI occurring during treatment in cancer patients treated with nivolumab.

Özet

Amaç: İmmünoterapi, kanser tedavisinde kullanım alanı gittikçe genişleyen ve daha sık tercih edilen bir tedavi seçeneği olarak ön plana çıkmaktadır. Bu yeni tedavi yöntemi, immün sistemin aktivasyonunu artırarak malignitelere karşı savunmayı güçlendirmektedir. Ancak, immün sistemin bu şekilde aktive edilmesi bazı immün yan etkilerin ve toksisitelerin görülmesine de yol açabilmektedir. Bu çalışmada, bir tür immün kontrol noktası inhibitörü (ICPI) olan nivolumab ile tedavi gören kanser hastalarında tedavi sürecinde gelişen akut böbrek hasarının insidansını, klinik özelliklerini ve olası risk faktörlerini retrospektif olarak incelemeyi amaçladık. Gereç ve Yöntemler: Bu çalışmada, nivolumab ile tedavi gören kanser hastalarında akut böbrek hasarının (ABH) görülme sıklığını, risk faktörlerini ve klinik sonuçlarını değerlendirdik. Bu amaçla, retrospektif olarak nivolumab ile tedavi edilen kanser hastalarının tıbbi kayıtları incelendi. ABH gelişen hastalarda; tedavi süreleri, kullanılan ilaç türleri, böbrek fonksiyonlarındaki değişiklikler, ekstrarenal yan etki gelişimi değerlendirildi. Bulgular: Çalışmaya 143 hasta alındı. Bu hastaların 116’sı erkek, 27’si kadındı. Yirmi üç hastada ABH gelişti. Hiçbir hastaya böbrek biyopsisi yapılarak immün kontrol noktası inhibitörü ilişkili (ICPI) nefrotoksisite kanıtlanmamıştır. ABH gelişen hastaların %30,4’ünde kronik böbrek hastalığı (KBH), %30,4’ünde exitus gelişmiş, %39,2’si iyileşmiştir. Başlangıç nötrofil/lenfosit oranı ve trombosit/lenfosit oranı yüksek olması ve eozinofil düşük olması ile nivolumab sonrası ABH gelişimi arasında anlamlı ilişki saptanmıştır. Nivolumab tedavisi sırasında nonsteroidal antiinflamatuar ilaç (NSAİD), proton pompa inhibitörü (PPİ) veya antibiyotik kullanımının ABH gelişimi ile ilişkisi saptanmamıştır. Ekstrarenal yan etkiler, komorbid hastalıklar ve kanser türü ile ABH gelişimi arasında ilişki saptanmamıştır. Sonuç: ICPI'ler, kanser tedavisinde önemli bir yer tutmakla birlikte, nefrotoksisite gibi ciddi yan etkilere de yol açabilmektedir. Bu nedenle, nivolumab ile tedavi gören hastaların böbrek fonksiyonlarının yakından izlenmesi büyük önem taşımaktadır. Bu çalışma, nivolumab tedavisi alan kanser hastalarında tedavi sürecinde gelişen akut böbrek hasarının insidansı, klinik özellikleri ve risk faktörlerine ilişkin bulgularıyla mevcut literatüre katkı sağlamayı amaçlamaktadır.

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Cite This Article

Ateş, Ü. C., Sarı, F. (2026). Retrospective Evaluation of Acute Kidney Injury In Patients Treated with Nivolumab at Akdeniz University Faculty of Medicine Hospital. Akdeniz Tıp Dergisi, Cilt: 12 Sayı: 1. https://doi.org/10.53394/akd.1795129

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References (44)

  1. World Health Organization. Global Health Estimates 2016: disease burden by cause, age, sex, by country and by region, 2000–2016. Geneva: World Health Organization; 2018.
  2. Smith SM, Wachter K, Burris HA 3rd, Schilsky RL, George DJ, Peterson DE, Johnson ML, Markham MJ, Mileham KF, Beg MS, Bendell JC, Dreicer R, Keedy VL, Kimple RJ, Knoll MA, LoConte N, MacKay H, Meisel JL, Moynihan TJ, Mulrooney DA, Mulvey TM, Odenike O, Pennell NA, Reeder-Hayes K, Smith C, Sullivan RJ, Uzzo R. Clinical cancer advances 2021: ASCO's report on progress against cancer. J Clin Oncol. 2021;39:1165–84.
  3. Sadeghi Rad H, Monkman J, Warkiani ME, Ladwa R, O'Byrne K, Rezaei N, Kulasinghe A. Understanding the tumor microenvironment for effective immunotherapy. Med Res Rev. 2021;41:1474–98.
  4. Liebl MC, Hofmann TG. Identification of responders to immune checkpoint therapy: which biomarkers have the highest value? J Eur Acad Dermatol Venereol. 2019;33 Suppl 14:52–6.
  5. Alexander W. The checkpoint immunotherapy revolution. P T. 2016;41:185–91.
  6. Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L, Daud A, Carlino MS, McNeil C, Lotem M, Larkin J, Lorigan P, Neyns B, Blank CU, Hamid O, Mateus C, Shapira-Frommer R, Kosh M, Zhou H, Ibrahim N, Ebbinghaus S, Ribas A; KEYNOTE-006 investigators. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med. 2015;372:2521–32.
  7. Ascierto PA, Long GV, Robert C, Brady B, Dutriaux C, Di Giacomo AM, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Ny L, Arance A, Svane IM, Schadendorf D, Gogas H, Saci A, Jiang Y, Rizzo J, Atkinson V. Survival outcomes in patients with previously untreated BRAF wild-type advanced melanoma treated with nivolumab therapy. JAMA Oncol. 2019;5:187–94.
  8. Robert C, Long GV, Brady B, Dutriaux C, Maio M, Mortier L, Hassel JC, Rutkowski P, McNeil C, Kalinka-Warzocha E, Savage KJ, Hernberg MM, Lebbé C, Charles J, Mihalcioiu C, Chiarion-Sileni V, Mauch C, Cognetti F, Arance A, Schmidt H, Schadendorf D, Gogas H, Lundgren-Eriksson L, Horak C, Sharkey B, Waxman IM, Atkinson V, Ascierto PA. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372:320–30.
  9. Rittmeyer A, Barlesi F, Waterkamp D, Park K, Ciardiello F, von Pawel J, Gadgeel SM, Hida T, Kowalski DM, Cobo Dols M, Cortinovis DL, Leach J, Polikoff J, Barrios C, Kabbinavar F, Arén Frontera O, De Marinis F, Turna H, Lee JS, Ballinger M, Kowanetz M, He P, Chen DS, Sandler A, Gandara DR; OAK Study Group. Atezolizumab versus docetaxel in NSCLC (OAK): a phase 3 trial. Lancet. 2017;389:255–65.
  10. Twomey JD, Zhang B. Cancer immunotherapy update: FDA approved checkpoint inhibitors and companion diagnostics. AAPS J. 2021;23:39.
  11. Ribas A. Releasing the brakes on cancer immunotherapy. N Engl J Med. 2015;373:1490–2.
  12. Postow MA, Sidlow R, Hellmann MD. Immune-related adverse events associated with immune checkpoint blockade. N Engl J Med. 2018;378:158–68.
  13. Conroy M, Naidoo J. Immune-related adverse events and the balancing act of immunotherapy. Nat Commun. 2022;13:392.
  14. Seethapathy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME. The incidence, causes, and risk factors of acute kidney injury in patients receiving immune checkpoint inhibitors. Clin J Am Soc Nephrol. 2019;14:1692–700.
  15. Seethapathy H, Zhao S, Strohbehn IA, Lee M, Chute DF, Bates H, Molina GE, Zubiri L, Gupta S, Motwani S, Leaf DE, Sullivan RJ, Rahma O, Blumenthal KG, Villani AC, Reynolds KL, Sise ME. Incidence and clinical features of immune-related acute kidney injury in patients receiving programmed cell death ligand-1 inhibitors. Kidney Int Rep. 2020;5:1700–5.
  16. Sorah JD, Rose TL, Radhakrishna R, Derebail VK, Milowsky MI. Incidence and prediction of immune checkpoint inhibitor-related nephrotoxicity. J Immunother. 2021;44:127–31.
  17. Meraz-Muñoz A, Amir E, Ng P, Avila-Casado C, Ragobar C, Chan C, Kim J, Wald R, Kitchlu A. Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes. J Immunother Cancer. 2020;8:e000467.
  18. Stein C, Burtey S, Mancini J, Pelletier M, Sallée M, Brunet P, Berbis P, Grob JJ, Honoré S, Gaudy C, Jourde-Chiche N. Acute kidney injury in patients treated with anti-programmed death receptor-1 for advanced melanoma: a real-life study in a single-centre cohort. Nephrol Dial Transplant. 2021;36:1664–74.
  19. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guidelines for acute kidney injury. Kidney Int Suppl. 2012;2:1–138.
  20. Common Terminology Criteria for Adverse Events (CTCAE) v5.0. Available from: https://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/CTCAE_v5_Quick_Reference_8.5x11.pdf. Accessed May 26, 2022.
  21. Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 2016;90:638–47.
  22. Manohar S, Kompotiatis P, Thongprayoon C, Cheungpasitporn W, Herrmann J, Herrmann SM. Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: meta-analysis. Nephrol Dial Transplant. 2019;34:108–17.
  23. Wanchoo R, Karam S, Uppal NN, Barta VS, Deray G, Devoe C, Launay-Vacher V, Jhaveri KD; Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors. Adverse renal effects of immune checkpoint inhibitors: a narrative review. Am J Nephrol. 2017;45:160–9.
  24. Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan ADM, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. Clinical features and outcomes of immune checkpoint inhibitor-associated AKI: a multicenter study. J Am Soc Nephrol. 2020;31:435–46.
  25. Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, De Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators. Acute kidney injury in patients treated with immune checkpoint inhibitors. J Immunother Cancer. 2021;9:e003467.
  26. Türkiye Kanser İstatistikleri 2018. Ankara: T.C. Sağlık Bakanlığı, Halk Sağlığı Genel Müdürlüğü; 2019.
  27. Türk Eczacıları Birliği. Kanser tedavisinde ilaç kullanım ilkeleri. SUT güncellemesi [Internet]. 2022 [cited 2023 Nov 11]. Available from: https://www.teb.org.tr
  28. Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int. 2016;90(3):638–47.
  29. Shirali AC, Perazella MA, Gettinger S. Association of acute interstitial nephritis with PD-1 inhibitor therapy in lung cancer patients. Am J Kidney Dis. 2016;68(2):287–91.
  30. Izzedine H, Mathian A, Champiat S, Picard C, Mateus C, Routier E, Varga A, Malka D, Leary A, Michels J, Michot JM, Marabelle A, Lambotte O, Amoura Z, Soria JC, Kaaki S, Quellard N, Goujon JM, Brocheriou I. Renal toxicities associated with pembrolizumab. Clin Kidney J. 2019;12(1):81–8.
  31. Mamlouk O, Selamet U, Machado S, Abdelrahim M, Glass WF, Tchakarov A, Gaber L, Lahoti A, Workeneh B, Chen S, Lin J, Abdel-Wahab N, Tayar J, Lu H, Suarez-Almazor M, Tannir N, Yee C, Diab A, Abudayyeh A. Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience. J Immunother Cancer. 2019;7(1):2.
  32. Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, De Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators. Acute kidney injury in patients treated with immune checkpoint inhibitors. J Immunother Cancer. 2021;9(10):e003467.
  33. Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan ADM, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. Clinical features and outcomes of immune checkpoint inhibitor-associated AKI: a multicenter study. J Am Soc Nephrol. 2020;31(2):435–46.
  34. Barroso-Sousa R, Barry WT, Garrido-Castro AC, Hodi FS, Min L, Krop IE, Tolaney SM. Incidence of endocrine dysfunction following the use of different immune checkpoint inhibitor regimens: a systematic review and meta-analysis. JAMA Oncol. 2018;4(2):173–82.
  35. Naidoo J, Wang X, Woo KM, Iyriboz T, Halpenny D, Cunningham J, Chaft JE, Segal NH, Callahan MK, Lesokhin AM, Rosenberg J, Voss MH, Rudin CM, Rizvi H, Hou X, Rodriguez K, Albano M, Gordon RA, Leduc C, Rekhtman N, Harris B, Menzies AM, Guminski AD, Carlino MS, Kong BY, Wolchok JD, Postow MA, Long GV, Hellmann MD. Pneumonitis in patients treated with anti–programmed death-1/programmed death ligand 1 therapy. J Clin Oncol. 2017;35(7):709–17.
  36. Meraz-Muñoz A, Amir E, Ng P, Avila-Casado C, Ragobar C, Chan C, Kim J, Wald R, Kitchlu A. Acute kidney injury associated with immune checkpoint inhibitor therapy: incidence, risk factors and outcomes. J Immunother Cancer. 2020;8(1):e000467.
  37. Gupta S, Cortazar FB, Riella LV, Leaf DE. Immune checkpoint inhibitor nephrotoxicity: update 2020. Kidney360. 2020;1(2):130–40.
  38. Seethapathy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME. The incidence, causes, and risk factors of acute kidney injury in patients receiving immune checkpoint inhibitors. Clin J Am Soc Nephrol. 2019;14(12):1692–700.
  39. Manohar S, Kompotiatis P, Thongprayoon C, Cheungpasitporn W, Herrmann J, Herrmann SM. Programmed cell death protein 1 inhibitor treatment is associated with acute kidney injury and hypocalcemia: meta-analysis. Nephrol Dial Transplant. 2019;34(1):108–17.
  40. Cantini L, Merloni F, Rinaldi S, Lenci E, Marcantognini G, Meletani T, Fiordoliva I, Morgese F, Torniai M, Ricci G, Giampieri R, Berardi R. Electrolyte disorders in advanced NSCLC patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis. Crit Rev Oncol Hematol. 2020;151:102974.
  41. Zhang W, Tan Y, Li Y, Liu J. Neutrophil to lymphocyte ratio as a predictor for immune-related adverse events in cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis. Front Immunol. 2023;14:1234142.
  42. Song M, Graubard BI, Rabkin CS, Engels EA. Neutrophil-to-lymphocyte ratio and mortality in the United States general population. Sci Rep. 2021;11(1):464.
  43. Drobni ZD, Zafar A, Zubiri L, Zlotoff DA, Alvi RM, Lee C, Hartmann S, Gilman HK, Villani AC, Nohria A, Groarke JD, Sullivan RJ, Reynolds KL, Zhang L, Neilan TG. Decreased absolute lymphocyte count and increased neutrophil/lymphocyte ratio with immune checkpoint inhibitor-associated myocarditis. J Am Heart Assoc. 2020;9(23):e018306.
  44. Gupta S, Short SAP, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang WT, Beckerman P, Mithani Z, Shah CV, Renaghan AD, De Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy H, Lee MD, Strohbehn IA, Owen DH, Husain M, Garcia-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Sarvode Mothi S, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE; ICPi-AKI Consortium Investigators. Acute kidney injury in patients treated with immune checkpoint inhibitors. J Immunother Cancer. 2021;9(6):e003467.