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Journals / Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi / 2026 / Cilt: 18 Sayı: 2

Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/Ssubstituted-1,4-naphthoquinone Derivatives

Yeni 5,8-Dibromo-2-O/S-sübstitüe-1,4-naftakinon Türevlerinin Sentezi ve Antimikrobiyal Aktivitelerinin Değerlendirilmesi

Kıymet Berkil Akar
Hasan Kılınç
Pages
451–457
Publication Date
2018-08-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results revealed that compound 3c has notable activity against all tested microorganisms.

📌 3 Key Takeaways

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Objective & Hypothesis:Novel bromo- and O/S-substituted-1,4-naphthoquninones (3a-3i) were synthesized via nucleophilic substitution reactions from 2,5,8-tribromo-1,4-naphthoquinone (1).
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Key Findings & Data:Compounds 3a, 3b, and 3c exhibited the greatest activity with MIC value of 61,25 μg/mL against P. vulgaris, B. cereus and B.subutilis, and B.cereus, respectively.
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Conclusion & Impact:Results revealed that compound 3c has notable activity against all tested microorganisms.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:4-Naftakinon · Nükleofilik · yerdeğiştirme

Abstract

Novel bromo- and O/S-substituted-1,4-naphthoquninones (3a-3i) were synthesized via nucleophilic substitution reactions from 2,5,8-tribromo-1,4-naphthoquinone (1). Antimicrobial evaluation of the newly synthesized derivatives was performed using agar spot method. Compounds 3a, 3b, and 3c exhibited the greatest activity with MIC value of 61,25 μg/mL against P. vulgaris, B. cereus and B.subutilis, and B.cereus, respectively. Results revealed that compound 3c has notable activity against all tested microorganisms.

Özet

2,5,8-Tribromo-l,4-naftokinon’dan (1) nükleofilik sübstitüsyon reaksiyonları ile yeni bromo- ve O/Ssübstitüe-1,4-naftokininon (3a-3i) türevleri sentezlendi. Yeni sentezlenen türevlerin antimikrobiyal olarak incelenmesi agar spot yöntemi kullanılarak gerçekleştirildi. Bileşik 3a, 3b ve 3c sırasıyla P. vulgaris, B. cereus ve B.subutilis, ve B.cereus'a karşı 61,25 ug/mL’lik MIC değeri ile en büyük aktivite sergiledi. Sonuçlar, bileşik 3c'nin test edilen tüm mikroorganizmalara karşı belirgin etkinliğe sahip olduğunu ortaya koymuştur.

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Cite This Article

Akar, K. B., Kılınç, H. (2018). Synthesis and Antimicrobial Evaluation of Novel 5,8-Dibromo-2-O/Ssubstituted-1,4-naphthoquinone Derivatives. Afyon Kocatepe Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, Cilt: 18 Sayı: 2, 451–457. https://ajindex.com/articles/1354908

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