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Journals / Hitit Medical Journal / 2026 / Cilt: 6 Sayı: 2

Brentuximab Vedotin Monotherapy in Relapsed/Refractory T Cell Lymphoma Setting-Real Life Data

Relaps / Refrakter T Hücreli Lenfomada Brentuximab Vedotin Monoterapisi- Gerçek Yaşam Verisi

Tahir Darcın(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-5073-1790
Istemi Serın(AĞRI EĞİTİM VE ARAŞTIRMAM HASTANESİ)0000-0003-1855-774X
Mehmet Can Ugur(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İZMİR BOZYAKA SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI, HEMATOLOJİ BİLİM DALI)0000-0002-5600-3169
Omer Ekinci(Hematology, University of Health Sciences, Gazi Yasargil Training and Research Hospital)0000-0002-4636-3590
İpek Yönal Hindilerden(Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Istanbul, Turkey)0000-0003-1353-2367
Seval Akpınar(TEKIRDAG NAMIK KEMAL UNIVERSITY, SCHOOL OF MEDICINE)0000-0002-6961-8971
Tuba Hacıbekiroglu(Hematology, Sakarya University)0000-0003-1814-5972
Sinan Demircioğlu(Hematology, Necmettin Erbakan University, Meram Faculty of Medicine)0000-0003-1277-5105
Emine Gulturk(Hematology, University of Health Sciences, Bakirkoy Dr. Sadi Konuk Training and Research Hospital)0000-0003-2836-6162
Murat Albayrak(ETLİK CITY HOSPITAL, DEPARTMENT OF HEMATOLOGY)0000-0003-4025-741X
İsmet Aydoğdu(Hematology, Celal Bayar University, Department of Internal Medicine)0000-0001-9350-1485
Mehmet Sinan Dal(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0002-5994-2735
Mehmet Hilmi Doğu(Hematology, Istinye University, Liv Hospital Ulus)0000-0001-7237-2637
Sinem Namdaroğlu(DOKUZ EYLÜL ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, İÇ HASTALIKLARI ANABİLİM DALI)0000-0002-8074-7301
Ali Dogan(Internal Medicine, Yuzuncu Yil University, School of Medicine)0000-0003-0207-3505
Meliha Nalçacı(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, HEMATOLOGY)0000-0002-2555-5024
Burhan Turgut(NAMIK KEMAL UNIVERSITY, SCHOOL OF MEDICINE)0000-0001-5729-0043
Semih Başcı(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ)0000-0003-4304-9245
Fevzi Altuntaş(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA DR. ABDURRAHMAN YURTASLAN ONKOLOJİ SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0001-6872-3780
Pages
186–192
Publication Date
2024-06-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In patients with relapsed/ refractory T cell lymphomas, BV seems to have convincing antitumor activity with favorable safety profile.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We present data of patients with relapsed/ refractory T cell lymphomas treated with brentuximab vedotin (BV) in real-world practice.
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Key Findings & Data:The data of patients (n=17) treated with BV alone from January 2014 until July 2020 in thirteen centers from Turkey were collected.
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Conclusion & Impact:Conclusion: In patients with relapsed/ refractory T cell lymphomas, BV seems to have convincing antitumor activity with favorable safety profile.
🔬Design:Araştırma Makalesi
📍Scope:2014 Verileri
⚙️Variables:brentuksimab vedotin · nüks · T hücreli lenfoma

Abstract

Objective: We present data of patients with relapsed/ refractory T cell lymphomas treated with brentuximab vedotin (BV) in real-world practice. Material and Method: This study is an observational, multi-center, retrospective study. The data of patients (n=17) treated with BV alone from January 2014 until July 2020 in thirteen centers from Turkey were collected. Results: Bv was given as salvage chemotherapy to 17 patients with median age of 53. Nine (52.9%) patients had diagnosis of peripheral T cell lymphoma, not otherwise specified; 8 (47.1%) patients had anaplastic large T cell lymphoma. The median follow-up of the cohort was 20 months. Nine (52.9%) patients had complete response, 5 (29.5%) had partial response, 3 (17.6%) had progressive disease. The safety results aligned with the established profile of BV, included 2 pneumonia and 1 thrombocytopenia with grade 4. The median progression free survival of the cohort was 10 months. BV cycle and response to BV therapy were found to have an effect on the univariate analysis. Conclusion: In patients with relapsed/ refractory T cell lymphomas, BV seems to have convincing antitumor activity with favorable safety profile.

Özet

Amaç: Brentuksimab vedotin (BV) ile tedavi edilen Relaps /Refrakter (R/R) THL’li hastaların gerçek yaşam verilerini sunmayı amaçladık. Gereç ve Yöntem: Bu çalışma gözlemsel, çok merkezli, retrospektif bir çalışmadır. Ocak 2014’ten Temmuz 2020’ye kadar Türkiye’deki on üç merkezde yalnızca BV ile tedavi edilen tüm hastaların (n=17) verileri toplandı. Bulgular: Ortanca yaşı 53 olan 17 hastaya kurtarma kemoterapisi olarak BV verildi. Dokuz (%52,9) hastaya periferik T hücreli lenfoma, diğer türlü sınıflandırılamayan tanısı konurken, 8 (%47,1) hastaya anaplastik büyük T hücreli lenfoma tanısı konuldu. Kohortun ortanca takip süresi 20 aydı. Dokuz (%52,9) hastada tam yanıt, 5 (%29,5) hastada kısmi yanıt, 3 (%17,6) hastada ilerleyici hastalık görüldü. Güvenlik verileri BV bilinen profiliyle tutarlıydı, 2 pnömoni ve 4. dereceli 1 trombositopeniyi içeriyordu. Grubun medyan progresyonsuz sağkalımı 10 aydı. Siklus sayısının BV tedavisine yanıtın üzerinde etkili olduğu değişkenli analiz ile bulundu. Sonuç: R/R THL’leri olan hastalarda BV olumlu güvenlik profili ile tatmin edici antitümör aktivitesine sahip olduğu görülmektedir.

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Cite This Article

Darcın, T., Serın, I., Ugur, M. C., Ekinci, O., Hindilerden, İ. Y., Akpınar, S., Hacıbekiroglu, T., Demircioğlu, S., Gulturk, E., Albayrak, M., Aydoğdu, İ., Dal, M. S., Doğu, M. H., Namdaroğlu, S., Dogan, A., Nalçacı, M., Turgut, B., Başcı, S., Altuntaş, F. (2024). Brentuximab Vedotin Monotherapy in Relapsed/Refractory T Cell Lymphoma Setting-Real Life Data. Hitit Medical Journal, Cilt: 6 Sayı: 2, 186–192. https://doi.org/10.52827/hititmedj.1320606

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