Journals / Hitit Medical Journal / 2024 / Cilt: 6 Sayı: 3

Efficacy of Continuous Renal Replacement Therapy in Metformin Intoxication: Case Report

Metformin Zehirlenmesinde Sürekli Renal Replasman Tedavinin Etkinliği: Olgu Sunumu

Kiraz Tekin Günaydın(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, TRABZON TIP FAKÜLTESİ, TRABZON TIP PR.)0009-0006-7614-4483
Ahmet Şen(Sağlık Bilimleri Üniversitesi Trabzon Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD.)0000-0001-8981-6871
Pages
385–390
Publication Date
2024-10-14
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In our patient with lactic acidosis due to metformin intoxication, we aimed to emphasise the efficacy of continuous renal replacement therapy because of the lack of response despite two intermittent haemodialysis and haemodynamic instability.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Metformin-associated lactic acidosis is seen in conditions that disrupt haemodynamics such as renal failure, hepatic failure, sepsis, septic shock or in acute poisoning.
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Key Findings & Data:Since the mortality rate of metformin-associated lactic acidosis is high, early diagnosis and treatment is important in reducing mortality.
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Conclusion & Impact:In our patient with lactic acidosis due to metformin intoxication, we aimed to emphasise the efficacy of continuous renal replacement therapy because of the lack of response despite two intermittent haemodialysis and haemodynamic instability.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Metformin · Sürekli renal replasman tedavisi · Yoğun bakım

Abstract

Metformin-associated lactic acidosis is seen in conditions that disrupt haemodynamics such as renal failure, hepatic failure, sepsis, septic shock or in acute poisoning. Since the mortality rate of metformin-associated lactic acidosis is high, early diagnosis and treatment is important in reducing mortality. Continuous renal replacement therapy is preferred especially in clinical conditions such as severe metabolic acidosis with haemodynamic instability, intoxication, hyperkalaemia and volume overload. In our patient with lactic acidosis due to metformin intoxication, we aimed to emphasise the efficacy of continuous renal replacement therapy because of the lack of response despite two intermittent haemodialysis and haemodynamic instability.

Özet

Metformin ilişkili laktik asidoz böbrek yetmezliği, karaciğer yetmezliği, sepsis, septik şok gibi hemodinamiyi bozan durumlarda ya da akut zehirlenmelerde görülür. Metformin ilişkili laktik asidozun mortalitesi yüksek olduğu için erken tanı ve tedavi mortaliteyi azaltmakta önemlidir. Sürekli renal replasman tedavisi özellikle hemodinamik anstabilite ile seyreden ciddi metabolik asidoz, zehirlenme, hiperkalemi, aşırı volüm yükü gibi klinik durumlarda tercih edilmektedir. Metformin zehirlenmesine bağlı gelişen laktik asidozlu olgumuzda iki kez aralıklı hemodiyaliz uygulanmasına rağmen yanıt alınamaması ve hemodinamik anstabilitesi olması nedeniyle hastaya uygulanan sürekli renal replasman tedavisinin etkinliğini vurgulamayı amaçladık.

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Cite This Article

Günaydın, K. T., Şen, A., Akyol, A. (2024). Efficacy of Continuous Renal Replacement Therapy in Metformin Intoxication: Case Report. Hitit Medical Journal, Cilt: 6 Sayı: 3, 385–390. https://doi.org/10.52827/hititmedj.1436657

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