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Journals / Hitit Medical Journal / 2026 / Cilt: 8 Sayı: 3

ABO Blood Group and Coronary Artery Disease Risk and Severity: Evidence from a Multi-Method Analytical Framework

ABO Kan Grubu ve Koroner Arter Hastalığı Riski ve Şiddeti: Çok Yöntemli Analitik Çerçeveden Elde Edilen Kanıtlar

Ercan Kahraman(AMASYA ÜNİVERSİTESİ)0000-0001-8106-3158
Şirin Çetin(AMASYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-9878-2554
Meryem Çetin(AMASYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-3307-9531
Özkan Özler(ISTANBUL ATLAS UNIVERSITY)0000-0003-1004-6080
Pages
636–650
Publication Date
2026-10-14
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No significant association between ABO blood groups and CAD was identified in any of the three analytical approaches: univariable (overall p=0.215), multivariable (overall p=0.304), or PSM analysis (overall p=0.324).

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The association between ABO blood groups and coronary artery disease (CAD) has been extensively investigated, yet findings remain inconsistent.
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Key Findings & Data:Materials and Methods: This retrospective case-control study enrolled 2,470 participants, comprising 1,305 patients with angiographically confirmed CAD and 1,165 controls.
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Conclusion & Impact:No significant association between ABO blood groups and CAD was identified in any of the three analytical approaches: univariable (overall p=0.215), multivariable (overall p=0.304), or PSM analysis (overall p=0.324).
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:ABO kan grubu · Ateroskleroz · Eğilim skoru eşleştirmesi

Abstract

Objective: The association between ABO blood groups and coronary artery disease (CAD) has been extensively investigated, yet findings remain inconsistent. This study aimed to evaluate this association in angiographically confirmed CAD using multiple complementary analytical approaches. Materials and Methods: This retrospective case-control study enrolled 2,470 participants, comprising 1,305 patients with angiographically confirmed CAD and 1,165 controls. The association between ABO blood groups and CAD was assessed using unadjusted logistic regression, multivariable logistic regression adjusted for cardiovascular risk factors, and propensity score matching (PSM). Subgroup analyses stratified by sex, age, and diabetes mellitus status were performed with interaction testing. Disease severity was evaluated using the Gensini score. Results: ABO blood group distribution did not differ significantly between CAD patients and controls (p=0.212). No significant association between ABO blood groups and CAD was identified in any of the three analytical approaches: univariable (overall p=0.215), multivariable (overall p=0.304), or PSM analysis (overall p=0.324). Subgroup analyses and interaction tests detected no significant effect modification by sex, age, or diabetes status. Gensini scores did not differ significantly across ABO blood groups among CAD patients (p=0.259). Conclusion: No significant association was found between ABO blood groups and the presence or severity of CAD. This finding was consistent across three complementary analytical approaches. This study provides evidence based on a comprehensive analytical framework in an area of the literature where conflicting results persist.

Özet

Amaç: ABO kan grupları ile koroner arter hastalığı (KAH) arasındaki ilişki kapsamlı bir şekilde araştırılmış, ancak bulgular tutarsız kalmıştır. Bu çalışma, bu ilişkiyi anjiyografik olarak doğrulanmış KAH'da çoklu tamamlayıcı analitik yaklaşımlar kullanarak değerlendirmeyi amaçlamıştır. Gereç ve Yöntem: Bu retrospektif olgu-kontrol çalışmasına, anjiyografik olarak doğrulanmış KAH'lı 1.305 hasta ve 1.165 kontrolden oluşan toplam 2.470 katılımcı dahil edilmiştir. ABO kan grupları ile KAH arasındaki ilişki düzeltilmemiş lojistik regresyon, kardiyovasküler risk faktörleri için düzeltilmiş çok değişkenli lojistik regresyon ve eğilim skoru eşleştirmesi (ESE) kullanılarak değerlendirilmiştir. Cinsiyet, yaş ve diabetes mellitus durumuna göre alt grup analizleri etkileşim testleriyle birlikte yapılmıştır. Hastalık şiddeti Gensini skoru kullanılarak değerlendirilmiştir. Bulgular: ABO kan grubu dağılımı KAH hastaları ile kontroller arasında anlamlı farklılık göstermemiştir (p=0,212). Üç analitik yaklaşımın hiçbirinde anlamlı ilişki saptanmamıştır: tek değişkenli (genel p=0,215), çok değişkenli (genel p=0,304) veya ESE analizi (genel p=0,324). Alt grup analizleri ve etkileşim testleri cinsiyet, yaş veya diyabet durumu tarafından anlamlı etki modifikasyonu tespit etmemiştir. Gensini skorları KAH hastaları arasında ABO kan gruplarına göre anlamlı farklılık göstermemiştir (p=0,259). Sonuç: ABO kan grupları ile KAH'ın varlığı veya şiddeti arasında anlamlı bir ilişki bulunamamıştır. Bu bulgu, üç tamamlayıcı analitik yaklaşım boyunca tutarlılık göstermiştir. Bu çalışma, çelişkili sonuçların devam ettiği literatürdeki bir alana kapsamlı bir analitik çerçeveye dayalı kanıt sunmaktadır.

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Cite This Article

Kahraman, E., Çetin, Ş., Çetin, M., Özler, Ö. (2026). ABO Blood Group and Coronary Artery Disease Risk and Severity: Evidence from a Multi-Method Analytical Framework. Hitit Medical Journal, Cilt: 8 Sayı: 3, 636–650. https://doi.org/10.52827/hititmedj.2002255

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