SavedAdd your journal

Journals / Uludağ Üniversitesi Tıp Fakültesi Dergisi / 2018 / Cilt: 44 - Sayı: 3

Protective Effect of Visnagin on Doxorubicin-Induced Ovarian Toxicity

Doksorubisin ile İndüklenmiş Ovaryan Toksisitede Visnaginin Koruyucu Etkisi

Aysun ÖZBAY
Berrin AVCI
Pages
143–151
Publication Date
2018-12-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, it was concluded that ovarian toxicity induced by doxorubicin was reduced with visnagin treatment and the visnagin treatment preserved of ovarian follicle reserve.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Different treatment approaches are used to for preserve ovarian reserve in ovarian toxicity due to doxorubicin.
📊
Key Findings & Data:In this study evaluating the therapeutic effect of visnagin in rats with ovarian toxicity induced by doxorubicin, it was determined that doxorubicin decreased the number of primordial follicles that determined ovarian reserve, as well as the number of preantral and antral follicles.
💡
Conclusion & Impact:As a result, it was concluded that ovarian toxicity induced by doxorubicin was reduced with visnagin treatment and the visnagin treatment preserved of ovarian follicle reserve.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Doksorubisin · Visnagin · Ovaryan Toksisite

Abstract

Different treatment approaches are used to for preserve ovarian reserve in ovarian toxicity due to doxorubicin. Visnagin is an organic chemical that shows therapeutic activity on doxorubicin-induced cardiotoxicity. However, the efficacy of visnagin on ovarian toxicity due to doxorubicin is unknown. In this study evaluating the therapeutic effect of visnagin in rats with ovarian toxicity induced by doxorubicin, it was determined that doxorubicin decreased the number of primordial follicles that determined ovarian reserve, as well as the number of preantral and antral follicles. Intraperitoneal administration of 30 mg/kg of visnagin treatment decreased the number of atretic follicles and preserved primordial, developing and mature follicle counts. As a result, it was concluded that ovarian toxicity induced by doxorubicin was reduced with visnagin treatment and the visnagin treatment preserved of ovarian follicle reserve.

Özet

Doksorubisine bağlı ovaryan toksisitede ovaryan rezervi korumak amacıyla farklı tedavi yaklaşımları uygulanmaktadır. Visnagin doksorubisine bağlı kardiyotoksisitede tedavi edici etkinliği gösterilmiş organik bir kimyasaldır. Bununla birlikte doksorubisine bağlı ovaryan toksisitede visnaginin etkinliği bilinmemektedir. Doksorubisine bağlı ovaryan toksisitenin oluşturulduğu sıçanlarda visnaginin tedavi edici etkinliğini değerlendiren bu çalışmada; doksorubisinin ovaryan rezervi belirleyen primordiyal follikül sayısını, bunun yanında preantral ve antral follikül sayısını azalttığı saptandı. İntraperitoneal 30 mg/kg visnagin tedavisinin primordiyal follikül rezervini, gelişmekte olan ve olgun follikül sayılarını koruduğu, atretik follikül sayısını azalttığı görüldü. Doksorubisin ile indüklenmiş ovaryan toksisitenin visnagin tedavisi ile azaltıldığı ve ovaryan follikül rezervini koruduğu sonucuna varıldı.

🔖

Cite This Article

ÖZBAY, A., AVCI, B. (2018). Protective Effect of Visnagin on Doxorubicin-Induced Ovarian Toxicity. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Cilt: 44 - Sayı: 3, 143–151. https://ajindex.com/articles/134712

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Monsuez J.-J, Charniot J.-C, Vignat N, & Artigou J.-Y Cardiac side-effects of cancer chemotherapy. International Journal of Cardiology 2010; 144(1), 3–15. Van Dyke T. p53 and tumor suppression. The New England Journal of Medicine, 2007; 356(1), 79–81.
  2. Bar-Joseph H, Ben-Aharon I, Rizel S, Stemmer SM, Tzabari M, et al. Doxorubicin-induced apoptosis in germinal vesicle (GV) oocytes. Reproductive Toxicology 2010;30: 566–572.
  3. Liu Y, Asnani A, Zou L, Bentley V. L, Yu M, Wang Y, Peterson R. T Visnagin protects against doxorubicin-induced cardiomyopathy through inhibtion of mitochondrial malate dehydrogenase. 2014; 6(266): 266ra170. Duarte J, Torres A. I, Zarzuelo A Cardiovascular effects of visnagin on rats. Planta Med. 2000; 66, 35-39.
  4. Vanachayangkul P, Byer K, Khan S, Butterweck V. An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells. Phytomedicine, 2010;17, 653-658.
  5. Ross MH, Pawlina W. Histology A Text And Atlas with Corralated Cell and Molacular Biology. 6th edition ed. Vol. LWW. 833-837, 2011.
  6. Garrett W M, Guthrie H. D Expression of Androgen Receptors and Steroidogenic Enzymes in Relation to Follicular Growth and Atresia Following Ovulation in Pigs, Biology of Reproduction, 1996; 55, 949-55.
  7. Ben-Aharon I, Bar-Joseph H, Tzarfaty G, Kuchinsky L, Rizel S, Stemmer SM, Shalgi R Doxorubicin-induced ovarian toxicity. Reprod Biol Endocrinol. 2010; 8:20. McLaughlin M, Kelsey T.W, Wallace W.H.B, Anderson R.A, Telfer E.E Non-growing follicle density is increased following adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemoterapy in the adult human ovary. Human Reproduction. Vol.32, No. I pp. 2017; 165-174.
  8. Oktay K, Oktem O, Reh A, Vahdat L Measuring the impact of chemotherapy on fertility in women with breast cance. J Clin Oncol. 2006; 24:4044-4046.
  9. Agarwal A, Gupta, S, Sharma R.K, Role of oxidative stress in female reproduction. Reprod. Biol. Endocrinol. 2005; 3, 28. Chow AY, Chin C, Dahl G, Rosenthal DN Anthracyclines cause endothelial injury in pediatric cancer patients: a pilot study. J Clin Oncol. 2006; 24:925-928.
  10. Wu S, Ko YS, Teng MS, Ko YL, Hsu LA, Hsueh C, Chou YY, Liew CC, Lee YS Adriamycin-induced cardiomyocyte and endothelial cell apoptosis: in vitro and in vivo studies. J Mol Cell Cardiol. 2002; 34:1595-1607.
  11. Zhang T, He W.N, Feng L.L, Huang H.G Effect Of Doxorubicin-İnduced Ovarian Toxicity On Mouse Ovarian Granulosa Cells. Regulatory Toxicology And