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Journals / Journal of Emergency Medicine Case Reports / 2025 / Cilt: 16 Sayı: 4

Unexpected Time of Age with A Rare Syndrome ALERD: Case Report

Beklenmedik Yaşta Nadir Bir Sendrom: ALERD Vakası

Nihal Yıldız(ZONGULDAK BULENT ECEVİT UNIVERSITY)0000-0003-0989-842X
Ezgi Genç Köroğlu(ZONGULDAK BÜLENT ECEVİT ÜNİVERSİTESİ)0000-0002-4535-7789
Pages
150–153
Publication Date
2025-12-31
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Eur J Paediatr Neurol. 2021, 33:86-93.

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract: This case report presents a rare instance of ALERD, highlighting its clinical presentation, diagnostic process, and management strategies.
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Key Findings & Data:A 17-year-old female patient exhibited with encephalopathy, prompting further investigation.
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Conclusion & Impact:Eur J Paediatr Neurol. 2021, 33:86-93.
🔬Design:Review & Systematic Survey
📍Scope:2018 Verileri
⚙️Variables:Ergen · ALERD · otoimmün ensefalit

Abstract

Abstract: This case report presents a rare instance of ALERD, highlighting its clinical presentation, diagnostic process, and management strategies. A 17-year-old female patient exhibited with encephalopathy, prompting further investigation. The case emphasizes the importance of early detection and intervention, contributing to the existing literature on ALERD. Introduction: ALERD is a rare disorder characterized by seizures, altered consciousness, and other neurological symptoms. It poses significant diagnostic challenges due to its symptoms. Understanding its clinical course and management strategies is crucial for improving patient outcomes. This report details a case of ALERD diagnosed in a 17-year-old female emphasizing key clinical features and treatment approaches. Case Report: A 17-year-old female presented with altered consciousness. Initial examinations revealed. Diagnostic workup, including serum, CSF levels and Magnetic resonance imaging confirmed ALERD. The patient was managed with pulse steroid and IVIG leading to opening in consciousness. This case underscores the need for early recognition and tailored therapeutic interventions. Conclusion: This case highlights the challenges associated with diagnosing and managing ALERD. Early identification and targeted interventions are crucial for optimal patient outcomes. Further research is needed to enhance diagnostic accuracy and develop standardized treatment protocols. 1. References: 1. Kamate M: Acute leukoencephalopathy with restricted diffusion . Indian J Crit Care Med. 2018, 22:519-23. 2. Lawrence RM, Aripirala P, Reddy N, et al.: The spectrum of acute leukoencephalopathy with restricted diffusion (ALERD): a case series and review of literature. Eur J Paediatr Neurol. 2021, 33:86-93.

Özet

Özet: Bu olgu sunumu, nadir görülen ALERD vakasının klinik bulgularını, tanı sürecini ve tedavi yaklaşımlarını ele almaktadır. 17 yaşında bir kadın hasta, ensefalopati belirtileriyle başvurdu ve yapılan ileri tetkikler sonucu ALERD tanısı konuldu. Bu olgu, erken teşhis ve müdahalenin önemini vurgulayarak ALERD hakkındaki mevcut literatüre katkı sağlamaktadır. Giriş: ALERD, nöbetler, bilinç değişiklikleri ve diğer nörolojik semptomlarla karakterize nadir bir hastalıktır. Klinik belirtileri nedeniyle tanı koyma süreci oldukça zordur. Hastalığın klinik seyri ve yönetim stratejilerinin anlaşılması, hasta sonuçlarını iyileştirmek açısından kritik öneme sahiptir. Bu olgu sunumunda, 17 yaşında bir kadın hastada ALERD tanısının konulma süreci, belirgin klinik özellikler ve uygulanan tedavi yaklaşımları ele alınmaktadır. Olgu Sunumu: 17 yaşındaki kadın hasta, bilinç değişikliği şikayeti ile başvurdu. Yapılan ilk değerlendirmelerde [...] saptandı. Serum, BOS analizleri ve manyetik rezonans görüntüleme (MRG) sonucu ALERD tanısı doğrulandı. Hastaya uygulanan pulse steroid ve intravenöz immünoglobulin (IVIG) tedavisi sonrasında bilinç durumu açılmaya başladı. Bu olgu, erken tanı ve bireyselleştirilmiş tedavi yaklaşımlarının önemini vurgulamaktadır. Sonuç: Bu olgu, ALERD tanı ve yönetimindeki zorlukları ortaya koymaktadır. Erken tanı ve hedefe yönelik tedavi yaklaşımları, hasta sonuçlarını iyileştirmek açısından büyük önem taşımaktadır. Hastalığın tanısal doğruluğunu artırmak ve standart tedavi protokollerini geliştirmek için daha fazla araştırmaya ihtiyaç vardır. Kaynaklar: Kamate M: Acute leukoencephalopathy with restricted diffusion. Indian J Crit Care Med. 2018, 22:519-23. Lawrence RM, Aripirala P, Reddy N, et al.: The spectrum of acute leukoencephalopathy with restricted diffusion (ALERD): a case series and review of literature. Eur J Paediatr Neurol. 2021, 33:86-93.

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Cite This Article

Yıldız, N., Köroğlu, E. G. (2025). Unexpected Time of Age with A Rare Syndrome ALERD: Case Report. Journal of Emergency Medicine Case Reports, Cilt: 16 Sayı: 4, 150–153. https://doi.org/10.33706/jemcr.1662308

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